Results 101 to 110 of about 1,184 (187)
Advanced Science, EarlyView.ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin +9 more
wiley +1 more source
Modular Assembly of Dynamic Polymer Networks From Heteroaffinity Cross‐Links to Multivalent Proteins
Angewandte Chemie, EarlyView.This study develops a method to modularly assemble oligomeric binding proteins, like streptavidin, using heterobifunctional cross‐linkers that have both a strong‐ and a weak‐affinity binding moiety. These dynamic cross‐linkers enable the assembly of polymer networks with unique meta‐stable nonequilibrium topologies, and that exhibit chemically tunable ...
Tianyue Dai +6 more
wiley +2 more sources
Shaped by context: Evolutionary trajectories of desiccation tolerance in land plants
American Journal of Botany, EarlyView.Abstract Desiccation tolerance (DT), the ability to survive near‐complete cellular dehydration, is widespread in diaspores but rare in the vegetative tissues of land plants. The patchy and punctuated phylogenetic distribution of vegetative desiccation tolerance (VDT) suggests that the trait is both ancient and recurrent, yet the evolutionary ...
Rose A. Marks +2 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Aqueously diffusible oligomers of the amyloid β‐protein (oAβ) are neurotoxic and play a role in neuronal dysfunction in Alzheimer's disease (AD). Accurate quantification of oAβ in brains and biofluids could be valuable for understanding and monitoring AD.
Yi Ran Xu +11 more
wiley +1 more source
Angewandte Chemie, EarlyView.Integrated structural analysis of N. vulgaris formate dehydrogenase AB, an enzyme with applications in climate change mitigation, is reported. The substrate/product diffusion pathways were fully mapped, and a retention site was identified that transiently holds substrates and has a key role in CO2‐reducing activity.
Guilherme Vilela‐Alves +8 more
wiley +2 more sources
Struktureller Mechanismus eines Aktivitäts‐Photoschalters am β2‐adrenergen Rezeptor
Angewandte Chemie, EarlyView.Zeitaufgelöste Strukturen aus Messungen an Röntgen‐Freie‐Elektronen‐Lasern in Kombination mit zellulären Assays zeigen, wie der photoschaltbare β‐Blocker Photoazolol‐1 als Wirksamkeits‐Photoschalter der Funktion des β2‐adrenergen Rezeptor wirkt. Die lichtinduzierte Neupositionierung des Liganden verschiebt die Aktivität von inversem Agonistimus hin zu ...
Robin Stipp +29 more
wiley +1 more source
A study of the stylistic markers of the language of cartoons in Nigeria
Studies in African Linguistics, 1991 This paper discusses the stylistic characteristics of the language of cartoons in some Nigerian newspapers. The analysis focuses on printing styles, stylistic registers, and textual features.
Modupe M. Alimi
doaj
Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor
Angewandte Chemie International Edition, EarlyView.Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp +29 more
wiley +1 more source
The Anatomical Record, EarlyView.An elastic segment was found in the basal part of the whisker shaft in rats and mice. Application of force to the whisker bulb of isolated follicles caused bending and twisting of this segment. Active whisker movements deform this segment, causing whisker shaft deflection and selective activation of mechanoreceptors at different phases of whisking ...
Sebastian Haidarliu +4 more
wiley +1 more source