Results 131 to 140 of about 1,184 (187)

A twofold development and demise of pine stands in the Netherlands during the Allerød interstadial: two hypotheses to explain a link to climate change recorded in Greenland ice

Journal of Quaternary Science, EarlyView.
ABSTRACT The second half of the Allerød interstadial in the Netherlands is characterised by pine forest. Excavated trunks of 165 pine trees at Leusden‐Den Treek in the central Netherlands (LETR16) were dated by dendrochronology and radiocarbon. Two chronologically separated pine forest phases occurred during relatively warm periods as recorded in ...
Wim Z. Hoek, Jos Bazelmans, Otto Brinkkemper, Petra Doeve, Bas van Geel   +4 more
wiley   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Faraday–Ramsey Rotation in Ultrathin Alkali Vapor Cells as an Analogy to Atomic‐Beam Systems

Laser &Photonics Reviews, EarlyView.
This work demonstrates that ultrathin rubidium vapor cells can emulate atomic‐beam behavior through geometry‐dependent velocity filtering. Employing a spatially separated pump–probe scheme and Faraday–Ramsey rotation, the study reveals coherent atomic dynamics without buffer gas or anti‐relaxation coatings. This approach offers a compact pathway toward
Mark Dikopoltsev, Eliran Talker, Yefim Barash, Noa Mazurski, Uriel Levy   +4 more
wiley   +1 more source

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Microencapsulated Alkane Wax Melting: Measured by 1$$ {}^1 $$H NMR Relaxometry and Diffusometry

Magnetic Resonance in Chemistry, EarlyView.
NMR relaxometry and diffusometry measurements detected greater molecular‐level disordering in microencapsulated n‐alkane waxes versus unencapsulated waxes throughout melting. ABSTRACT Phase change materials (PCMs) are useful for energy storage. Large latent heats make n‐alkane waxes effective PCMs.
Matthew C. Young, Madison L. Nelson, Matthew E. Skuntz, Sarah L. Codd, Ryan Anderson, Joseph D. Seymour   +5 more
wiley   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

The Analgesic Effect of Extended Reality (XR) on Acute and Postoperative Pain in Children: A Systematic Review and Meta‐Analysis

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Acute and postoperative pain in children is often undertreated, with effects on patient comfort and postoperative recovery. Extended reality (XR) interventions offer non‐pharmacological pain management by distracting patients from discomfort.
Louise Meulenkamp‐Yilmaz, Souraya El Bardai, Manon H. J. Hillegers, Jeroen Legerstee, Bram Dierckx, Lonneke Staals   +5 more
wiley   +1 more source

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

The N‐Glycome to Differentiate Mesenchymal Stem Cells Upon Chondrogenic Differentiation, Dedifferentiation, and Senescence

PROTEOMICS, EarlyView.
ABSTRACT Mesenchymal stem cells (MSCs) are adult stem cells able to self‐renewal or differentiation into different cell types, including chondrocytes. N‐Glycans are post‐translational modifications of glycoproteins that contribute to vital cell functions.
Houda Montacir, Karina Biskup, Michael Sittinger, Rudolf Tauber, Véronique Blanchard   +4 more
wiley   +1 more source