Results 41 to 50 of about 169,180 (287)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Picturing the Charlie Hebdo Incident in Arabic Political Cartoons

open access: yesArab Studies Quarterly, 2016
This article investigates how the Arabic political cartoons picture the mocking cartoons of the Prophet Muhammad by the French satirical Charlie Hebdo magazine.
Sadam Issa
doaj   +1 more source

Disraeli and “One Nation” in British cartoons, 1914-2016

open access: yesRevue Française de Civilisation Britannique, 2023
This paper analyzes the cartoons featuring Benjamin Disraeli after his death and the concept of “One Nation”. It shows that Disraeli remained through the 20th century a persona which British cartoonists recurringly made use of, although Churchill, and to
Philippe Vervaecke
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Designing a web-application to support home-based care of childhood CKD stages 3-5: Qualitative study of family and professional preferences [PDF]

open access: yes, 2014
Background: There is a lack of online, evidence-based information and resources to support home-based care of childhood CKD stages 3-5. Methods. Qualitative interviews were undertaken with parents, patients and professionals to explore their views on ...
Carolan, I.   +6 more
core   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Cartoon-based message strategies on vaccination in Romania and engagement behavior. A multimodal approach.

open access: yesRomanian Journal of Communications and Public Relations
This study investigates the influence of Romanian cartoons related to COVID-19 vaccination on online engagement. Humor has been employed by (inter)national authorities in order to simplify complex issues and to encourage positive attitudes and behaviors
Camelia Cmeciu
doaj   +1 more source

Hate speech or legitimate satire? Drawing the line in cartoons

open access: yesHermes, 2023
Controversial cartoons appearing in contemporary news and social media are periodically denounced by consumers for hate speech, and argued over in blogs, reader comments and news articles.
Elizabeth Swain
doaj   +1 more source

Newspaper cartoon and political education in Nigeria: The artists' ideal [PDF]

open access: yes, 2015
This paper sets out to identify the qualities of a cartoonist as an artist in the business of political education. The paper observes that the true meaning of any man’s action could be understood when conscious efforts are made by the message recipients ...
Iyorza, Stanislaus
core  

Media discourse on jihadist terrorism in Europe [PDF]

open access: yes, 2013
This article analyzes the manner in which European print media discuss jihadist terrorism in Europe. It presents key results from a qualitative analysis of media discourse following three selected attacks in seven European countries in 2010: the attack ...
Reinke de Buitrago, Sybille
core   +2 more sources

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