Results 31 to 40 of about 38,527 (248)

PHARMACOECONOMIC ANALYSIS OF CARVEDILOL THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AND METABOLIC RISK FACTORS (ACCORDING TO THE CAMELLIA STUDY)

Рациональная фармакотерапия в кардиологии, 2016
Aim. To perform cost-effectiveness analysis of 24 weeks antihypertensive therapy based on carvedilol or metoprolol in patients with arterial hypertension (HT) 1-2 degrees and overweight/obesity. To assess effects of carvedilol therapy on 10-year expected
S. Y. Martsevich, N. P. Kutishenko, A. D. Deev, S. A. Shalnova, R. G. Oganov   +4 more
doaj   +1 more source

In vitro and in silico study on the effect of carvedilol and sorafenib alone and in combination on the growth and inflammatory response of melanoma cells

Saudi Pharmaceutical Journal, 2023
Melanoma is an aggressive skin cancer. Increasing evidence has shown the role of β-adrenergic receptors in the pathogenesis of melanoma. Carvedilol is a widely used non-selective β-AR antagonist with potential anticancer activity.
Joanna Wawszczyk, Radosław Wolan, Sławomir Smolik, Małgorzata Kapral   +3 more
doaj   +1 more source

Effectiveness and Dose of Carvedilol Therapy In Children with Dilated Cardiomyopathy: A Prospective Randomized Double-Blinded Trial [PDF]

Pediatric Sciences Journal, 2021
Background: The efficacy and safety of the beta blocker carvedilol in pediatric patients with chronic heart failure (CHF) has not been fully established till now.
Zeinab S. Seliem, Sonia A. El Saiedi, Reem I. Esmail, Rania M. H. El Kaffas, Mohamed Meabed, Baher M. Hanna   +5 more
doaj   +1 more source

Vitamin C inhibits endothelial cell apoptosis in congestive heart failure [PDF]

, 2007
Background - Proinflammatory cytokines like tumor necrosis factor- and oxidative stress induce apoptotic cell death in endothelial cells (ECs). Systemic inflammation and increased oxidative stress in congestive heart failure (CHF) coincide with enhanced ...
Aicher, A, Dimmeler, S, Freyssinet, JM, Haase, A, Hoffmann, J, Hugel, B, Mallat, Z, Rossig, L, Tedgui, A, Zeiher, AM   +9 more
core   +1 more source

Carvedilol versus propranolol in the prevention of variceal rebleeding in hepatosplenic schistosomiasis: Efficacy and safety

JGH Open, 2022
Background and Aim Beta blockers combined with endoscopic variceal band ligation (EVL) is the most effective means for the prevention of variceal rebleeding.
Chantelli Iamblaudiot Razafindrazoto, Lova Dany Ella Razafindrabekoto, Domoina Harivonjy Hasina Laingonirina, Raveloson Raveloson, Anjaramalala Sitraka Rasolonjatovo, Andry Lalaina Rinà Rakotozafindrabe, Tovo Harimanana Rabenjanahary, Soloniaina Hélio Razafimahefa, Rado Manitrala Ramanampamonjy   +8 more
doaj   +1 more source

Partial pharmacologic blockade shows sympathetic connection between blood pressure and cerebral blood flow velocity fluctuations [PDF]

, 2016
Cerebral autoregulation (CA) dampens transfer of blood pressure (BP)-fluctuations onto cerebral blood flow velocity (CBFV). Thus, CBFV-oscillations precede BP-oscillations.
Hauck, P, Hilz, MJ, Hösl, KM, Köhrmann, M, Liu, M, Marthol, H, Riss, S, Stemper, B, Tillmann, A, Wang, R, Wasmeier, G   +10 more
core   +1 more source

Assessment of clinical effect and treatment quality of immediate-release carvedilol-IR versus SLOW release carvedilol-SR in Heart Failure patients (SLOW-HF): study protocol for a randomized controlled trial

Trials, 2018
Background Carvedilol is a non-selective, third-generation beta-blocker and is one of the cornerstones for treatment for patients with heart failure and reduced ejection fraction (HFrEF). However, due to its short half-life, immediate-release carvedilol (
Dong-Ju Choi, Chan Soon Park, Jin Joo Park, Hae-Young Lee, Seok-Min Kang, Byung-Su Yoo, Eun-Seok Jeon, Seok Keun Hong, Joon-Han Shin, Myung-A Kim, Dae-Gyun Park, Eung-Ju Kim, Soon-Jun Hong, Seok Yeon Kim, Jae-Joong Kim   +14 more
doaj   +1 more source

Carvedilol Protects against Doxorubicin-Induced Mitochondrial Cardiomyopathy [PDF]

, 2002
Several cytopathic mechanisms have been suggested to mediate the dose-limiting cumulative and irreversible cardiomyopathy caused by doxorubicin. Recent evidence indicates that oxidative stress and mitochondrial dysfunction are key factors in the ...
Froberg, M. K., Leino, R. L., Moreno, A. J. M., Santos, D. L., Wallace, K. B.   +4 more
core   +1 more source

Differential effects of adrenergic antagonists (Carvedilol vs Metoprolol) on parasympathetic and sympathetic activity: a comparison of clinical results

Heart International, 2014
Background Cardiovascular autonomic neuropathy (CAN) is recognized as a significant health risk, correlating with risk of heart disease, silent myocardial ischemia or sudden cardiac death.
Heather L. Bloom, Aaron I. Vinik, Joe Colombo   +2 more
doaj   +1 more source

Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade [PDF]

, 2012
Chronic β-adrenoceptor antagonist (β-blocker) treatment in patients is associated with a potentially anti-arrhythmic prolongation of the atrial action potential duration (APD), which may involve remodelling of repolarising K+ currents.
A Alday, A Maguy, AA Dawodu, AEG Raine, AJ Camm, AJ Workman, AJ Workman, AJ Workman, AJ Workman, AJ Workman, Andrew C. Rankin, Antony J. Workman, B Fermini, CA Karle, CJ Redpath, D Dobrev, D Escande, F Cao, F Lesage, G Bru-Mercier, Gillian E. Marshall, GR Li, J Lopez-Sendon, James O. Tellez, JL Greenstein, JM Nerbonne, JM Nerbonne, John Dempster, Julie A. Russell, Kathleen A. Kane, M Courtemanche, M Courtemanche, M Fink, M Greiser, Mark R. Boyett, N Gaborit, N Niwa, Pardeep S. Jhund, QY Liu, RP Xiao, S Koumi, S Nattel, Susan Currie, SV Pandit, T Christ, U Schotten, W Kong   +46 more
core   +1 more source