Results 31 to 40 of about 44,151 (306)

The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors

Andrology, Volume 11, Issue 2, Page 257-269, February 2023., 2023
Abstract Introduction Erectile dysfunction is associated with diabetes mellitus with an estimated prevalence of 52.5% in the diabetic population. The first‐line therapy for erectile dysfunction is phosphodiesterase type 5 inhibitors, but data suggest that diabetic men may be less responsive than non‐diabetic men.
Axel Alberto Cayetano‐Alcaraz, Tharu Tharakan, Runzhi Chen, Nikolaos Sofikitis, Suks Minhas   +4 more
wiley   +1 more source

Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor

Molecular Pharmacology, 2021
Among β-blockers that are clinically prescribed for heart failure, carvedilol is a first-choice agent with unique pharmacological properties. Carvedilol is distinct from other β-blockers in its ability to elicit β-arrestin–biased agonism, which has been ...
Biswaranjan Pani, Seungkirl Ahn, Paula K. Rambarat, Shashank Vege, Alem W. Kahsai, Andrew Liu, Bruno N Valan, D. Staus, T. Costa, R. Lefkowitz   +9 more
semanticscholar   +1 more source

Synthesis of Carvedilol–Organotin Complexes and Their Effects on Reducing Photodegradation of Poly(Vinyl Chloride)

Polymers, 2021
Poly(vinyl chloride) (PVC) undergoes photodegradation induced by ultraviolet (UV) irradiation; therefore, for outdoor applications, its photostability should be enhanced through the use of additives.
Omar G. Mousa, G. El‐Hiti, Mohammed A. Baashen, Muna Bufaroosha, Ahmed A. Ahmed, Ahmed A. Ahmed, D. Ahmed, E. Yousif   +7 more
semanticscholar   +1 more source

Carvedilol in the failing heart [PDF]

Clinical Cardiology, 2001
AbstractPatients with chronic heart failure due to left ventricular systolic dysfunction of ischemic or nonischemic etiology have shown improvement in morbidity and mortality with carvedilol therapy. In patients with symptomatic (New York Heart Association class II–IV) heart failure, carvedilol improves left ventricular ejection fraction and clinical ...
Edward M. Gilbert, William L. Lombardi
openaire   +3 more sources

Comparative effectiveness of bisoprolol and carvedilol among patients receiving maintenance hemodialysis

Clinical Kidney Journal, 2021
Background Despite widespread use, there is no trial evidence to inform β-blocker’s (BB) relative safety and efficacy among patients undergoing hemodialysis (HD).
P. Wu, Yi-Ting Lin, Jia-Sin Liu, Yi-Chun Tsai, M. Kuo, Y. Chiu, Shang-Jyh Hwang, J. Carrero   +7 more
semanticscholar   +1 more source

Prophylactic use of carvedilol to prevent ventricular dysfunction in patients with cancer treated with doxorubicin [PDF]

, 2018
Objective: Deterioration in ventricular function is often observed in patients treated with anthracyclines for cancer. There is a paucity of evidence on interventions that might provide cardio-protection.
Abrar, Mohammed Burhan, Abuosa, Ahmed Mohamed, Ahmed, Adel H., Andejani, Abdulwahab, Cleland, John G.F., Elshiekh, Ayman Hassan, Kholeif, Mona A., Kinsara, Abdulhalim Jamal, Qureshi, Kahekashan   +8 more
core   +1 more source

Unrecognized liver cirrhosis is common and associated with worse survival in hepatocellular carcinoma: A nationwide cohort study of 3473 patients

Journal of Internal Medicine, Volume 293, Issue 2, Page 184-199, February 2023., 2023
Abstract Background Data on unrecognized liver cirrhosis in patients with hepatocellular carcinoma (HCC) are derived mainly from cohorts with a risk of selection bias. Objectives In a population‐based cohort study we aimed to determine the proportion, characteristics, and prognosis of HCC in patients with unrecognized cirrhosis.
Juan Vaz, Ulf Strömberg, Patrik Midlöv, Berne Eriksson, David Buchebner, Hannes Hagström   +5 more
wiley   +1 more source

Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa

Scientific Reports, 2021
Retinitis Pigmentosa (RP) is a mostly incurable inherited retinal degeneration affecting approximately 1 in 4000 individuals globally. The goal of this work was to identify drugs that can help patients suffering from the disease.
Logan Ganzen, M. Ko, Mengrui Zhang, Rui Xie, Yongkai Chen, Liyun Zhang, Rebecca James, J. Mumm, R. V. van Rijn, Wenxuan Zhong, C. Pang, Mingzhi Zhang, M. Tsujikawa, Yuk Fai Leung   +13 more
semanticscholar   +1 more source

Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans : lost in translation [PDF]

, 2013
We greatly appreciate the comments offered by Drs Rolle, Takematsu, and Hoffman and the opportunity to put our work into a wider perspective. We share the view that our work does not reflect the clinical situation but rather provides a proof of mechanism
Boehrer, Brunt, Dafters, Docherty, Grunau, Henry, Hysek, Hysek, Hysek, Hysek, Hysek, Liechti, Liechti, Martin, Mills, Mithoefer, Morefield, Oehen, Parrott, Ramoska, Rietjens, Rogers, Rusyniak, Schutte, Sprague, Sprague, Williams   +26 more
core   +1 more source

Prevention of Skin Carcinogenesis by the Non-β-blocking R-carvedilol Enantiomer

Cancer Prevention Research, 2021
In this study, we demonstrated the skin cancer preventive activity of R-carvedilol, the non-β-blocking enantiomer present in the racemic β-blocker, carvedilol.
Sherry Liang, M. Shamim, A. Shahid, Mengbing Chen, Kristan H Cleveland, C. Parsa, R. Orlando, B. Andresen, Ying Huang   +8 more
semanticscholar   +1 more source