Results 61 to 70 of about 38,527 (248)

Biomarkers of Extracellular Matrix Remodelling Are Linked to Severity and Outcome of Advanced Chronic Liver Disease

Alimentary Pharmacology &Therapeutics, EarlyView.
Extracellular matrix (ECM) remodelling biomarkers reflect portal hypertension and disease severity in advanced chronic liver disease (ACLD). However, their predictive value for disease progression is largely restricted to compensated ACLD (cACLD). ABSTRACT Background Extracellular matrix (ECM) remodelling in advanced chronic liver disease (ACLD) is ...
Benedikt Simbrunner, Ida Falk Villesen, Georg Semmler, Lorenz Balcar, Georg Kramer, Joana Almeida Calvão, Benedikt Silvester Hofer, Mathias Jachs, Lukas Hartl, Jurij Maurer, Bernhard Scheiner, Kerstin Zinober, Rodrig Marculescu, Michael Trauner, Morten Karsdal, Thomas Reiberger, Mattias Mandorfer, Diana Julie Leeming   +17 more
wiley   +1 more source

Synthesis and Characterization of Carvedilol-Etched Halloysite Nanotubes Composites with Enhanced Drug Solubility and Dissolution Rate

Molecules, 2023
Carvedilol is a poorly water-soluble drug employed to treat chronic heart failure. In this study, we synthesize new carvedilol-etched halloysite nanotubes (HNTs) composites to enhance solubility and dissolution rate.
Lauretta Maggi, Claudia Urru, Valeria Friuli, Chiara Ferrara, Debora Maria Conti, Giovanna Bruni, Doretta Capsoni   +6 more
doaj   +1 more source

Β-blockers treatment of cardiac surgery patients enhances isolation and improves phenotype of cardiosphere-derived cells [PDF]

, 2016
Β-blockers (BB) are a primary treatment for chronic heart disease (CHD), resulting in prognostic and symptomatic benefits. Cardiac cell therapy represents a promising regenerative treatment and, for autologous cell therapy, the patients clinical history ...
ANGELINI, FRANCESCO, BARRETTA, ANTONIO, BIONDI ZOCCAI, GIUSEPPE, CAVARRETTA, Elena, CHIMENTI, ISOTTA, DE FALCO, ELENA, FRATI, GIACOMO, GRECO, Ernesto, MARULLO, Antonino, PAGANO, FRANCESCA, PERUZZI, MARIANGELA, SCIARRETTA, SEBASTIANO   +11 more
core   +1 more source

Spontaneous Bacterial Peritonitis Is Associated With High Mortality, Which Interacts With Antibiotic Prophylaxis in a National Cirrhosis Cohort

Alimentary Pharmacology &Therapeutics, EarlyView.
In a national cohort of newly decompensated Veterans with cirrhosis, SBP and recurrences are linked with higher death and need for liver transplant. SBP prophylaxis, whether primary or secondary, worsens resistance and interacts with mortality but not liver transplant.
Scott Silvey, Nilang Patel, Jacqueline G. O'Leary, Timothy Morgan, John D. Markley, Sofia S. Jakab, Heather Patton, Shari Rogal, Jasmohan S. Bajaj   +8 more
wiley   +1 more source

Formulation and Characterization of Carvedilol Leciplex for Glaucoma Treatment: In-Vitro, Ex-Vivo and In-Vivo Study

Pharmaceutics, 2018
This study evaluated the efficacy of cationic nanoparticle (leciplex) to deliver carvedilol to ocular surface for glaucoma treatment as recent studies pointed out the effect of topical carvedilol on intraocular pressure, therefore carvedilol loaded ...
Doaa H. Hassan, Rehab Abdelmonem, Menna M. Abdellatif   +2 more
doaj   +1 more source

Development of a Carvedilol Oral Liquid Formulation for Paediatric Use [PDF]

, 2023
Blanca Chiclana-Rodríguez, E. García-Montoya, Khadija Rouaz-El-Hajoui, Miquel Romero-Obón, Anna Nardi-Ricart, Marc Suñé-Pou, Josep M. Suñé‐Negre, Pilar Pérez‐Lozano   +7 more
openalex   +1 more source

Statin Therapy Independently Reduces Mortality and Liver Complications in Patients With Cirrhosis: An Updated Systematic Review and Meta‐Analysis

Alimentary Pharmacology &Therapeutics, EarlyView.
Statin therapy in cirrhosis may confer a survival benefit while reducing the risk of hepatic decompensation and hepatocellular carcinoma. ABSTRACT Background The role of statins in cirrhosis remains controversial. Historically restricted due to safety concerns, emerging evidence highlights potential pleiotropic benefits, though effects on mortality and
Bernardo de Faria Moraes, Gustavo André Pedral Diniz Leite, Igor Boechat Silveira, Gabriel André Pedral Diniz Leite, Maria Luisa Motta Fonseca, Leonardo Corrêa Suffert, Luisa Medeiros Visentini, Luis Pedro Possapp Beis, Guilherme Grossi Lopes Cançado   +8 more
wiley   +1 more source

Inhibitory effect of carvedilol on bedaquiline metabolism in vitro and in vivo [PDF]

PeerJ
Bedaquiline has recently been approved for the treatment of multidrug-resistant tuberculosis. Carvedilol is a cardiovascular medication extensively used in the treatment of heart failure and hypertension.
Qingqing Li, Wanshu Li, Jie Chen, Hangjuan Lin, Cixia Zhou   +4 more
doaj   +2 more sources

Carvedilol for prevention of restenosis after directional coronary atherectomy : final results of the European carvedilol atherectomy restenosis (EUROCARE) trial [PDF]

, 2000
BACKGROUND: In addition to its known properties as a competitive, nonselective beta and alpha-1 receptor blocker, carvedilol directly inhibits vascular myocyte migration and proliferation and exerts antioxidant effects that are ...
Betriu, A., Bonnier, J.J.R.M. (Hans), Coste, P. (Pierre), Foley, D.P. (David), Glogar, H.D. (Helmut), Goicolea, J. (Javier), Hauf-Zachariou, U., Hofling, B., Katus, H.A. (Hugo), Melkert, R. (Rein), Montauban van Swijndregt, E.W.J. (Eline), Puel, J. (Jacques), Rutsch, W.R. (Wolfgang), Seabra-Gomes, R. (Ricardo), Serruys, P.W.J.C. (Patrick), Simon, R. (Rudiger), Wijns, W. (William)   +16 more
core   +1 more source

Cryptococcid Sweet Syndrome in the Setting of Hydralazine‐Induced ANCA Vasculitis: A Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Acute febrile neutrophilic dermatosis, also known as Sweet syndrome, is an inflammatory skin condition characterized by the rapid onset of painful, erythematous plaques or nodules with neutrophilic infiltrate on histology. Rarely, acellular bodies surrounded by vacuolated spaces have been noted within the neutrophilic infiltrate, mimicking ...
Jenna Vroman, Pelin Sagut, Kathryn Lynam, Amanda Ederle, Laura Winterfield   +4 more
wiley   +1 more source