Results 191 to 200 of about 251,083 (336)

Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity

Advanced Science, EarlyView.
In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang, Jiahui Zou, Yaoming Jin, Chenjun Jiang, Shaoyu Tu, Tong Chen, Jinli Guo, Yanqing Cheng, Meilin Jin, Huanchun Chen, Hongbo Zhou   +10 more
wiley   +1 more source

Dual sgRNAs facilitate CRISPR/Cas9‐mediated mouse genome targeting [PDF]

, 2014
Jiankui Zhou, Jianying Wang, Bin Shen, Li Chen, Su Yang, Jing Yang, Zhi‐Gang She, Xuemei Tian, Xingxu Huang   +8 more
openalex   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells [PDF]

, 2014
Luhan Yang, Dennis Grishin, Gang Wang, John Aach, Cheng‐Zhong Zhang, Raj Chari, Jason Homsy, Xuyu Cai, Yue Zhao, Jian‐Bing Fan, Christine E. Seidman, Jonathan G. Seidman, William T. Pu, George M. Church   +13 more
openalex   +1 more source

Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity

Advanced Science, EarlyView.
This study uncovers a spatiotemporal regulation of STING activity by linear ubiquitination in antiviral immunity. At the early stage of the infection, LUBAC promotes STING linear ubiquitination to drive its trafficking from the ER to the Golgi apparatus for activation.
Yong Zhang, Yesheng Fu, Lihua Qiang, Mengyuan Zhao, Zhe Lu, Zhuo Zhao, Guoping Chen, Zehui Lei, Qiyao Chai, Pupu Ge, Bingxi Li, Jing Wang, Cui Hua Liu, Lingqiang Zhang   +13 more
wiley   +1 more source

Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage

, 2014
Regina Cencic, Hisashi Miura, Abba Malina, Françis Robert, Sylvain Éthier, T.M. Schmeing, Josée Dostie, Jerry Pelletier   +7 more
openalex   +2 more sources

Multiple genome modifications by the CRISPR/Cas9 system in zebrafish [PDF]

, 2014
Satoshi Ota, Yu Hisano, Yoshiya Ikawa, Atsuo Kawahara   +3 more
openalex   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

Harnessing an anti-CRISPR protein for powering CRISPR/Cas9-mediated genome editing in undomesticated Bacillus strains. [PDF]

Microb Cell Fact
Kim MS, Jeong DE, Choi SK.
europepmc   +1 more source

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

, 2014
Hiroshi Nishimasu, F. Ann Ran, Patrick D. Hsu, Silvana Konermann, Soraya I. Shehata, Naoshi Dohmae, Ryuichiro Ishitani, Feng Zhang, Osamu Nureki   +8 more
openalex   +1 more source