Results 191 to 200 of about 278,076 (329)

490. Removing the dopaminergic inhibition with CRISPR-Cas9 to study the progression of sexual maturation in zebrafish

, 2022
Pauline Jéhannet, A.A.C. de Wit, Sylvia Brugman, Yumao Zhang, Jan Bogerd, Arjan P. Palstra   +5 more
openalex   +2 more sources

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source

Physical stimuli-responsive CRISPR-Cas9 systems for spatiotemporally precise control of genome engineering. [PDF]

Theranostics
Pan J, Li B, Wang Y, Han Y, Liu G, Sun SK.   +5 more
europepmc   +1 more source

eLife Assessment: Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

Noriaki Ono
openalex   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Optimization of lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes for in vivo delivery of a CRISPR/Cas9 system targeting hepatitis B virus. [PDF]

Virus Res
Akhter R, Kitab B, Kayesh MEH, Shimizu R, Onuma H, Yamamoto N, Ogawa S, Sugiyama M, Tanaka Y, Sato Y, Kohara M, Tsukiyama-Kohara K.   +11 more
europepmc   +1 more source

Crispr/Cas9-Mediated Deletion of Mmd2 Gene Affects the Growth of Exopalaemon Carinicauda

Yuke Bu, Yujie Liu, Rongxiao Wang, Shangpeng Wang, Chunyu Zhang, Yuying Sun, Jiquan Zhang   +6 more
openalex   +1 more source

Creation of a genetic vector carrying a synthesis bacterial protein gene CAS9 for plant genome editing

, 2020
I. S. Hnatiuk, O. I. Varchenko, М. Ф. Парій, Yu. V. Symonenko   +3 more
openalex   +2 more sources

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Disrupting Viral Persistence: CRISPR/Cas9-Based Strategies for Hepatitis B and C Treatment, and Challenges. [PDF]

J Cell Mol Med
Li MF, Zubair A, Wdidi S, He S.
europepmc   +1 more source