Results 251 to 260 of about 278,076 (329)

Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9 [PDF]

, 2019
Curiel, David T, Kashentseva, Elena, Lauron, Elvin J, Lu, Zhi Hong, Stephens, Calvin J, Yokoyama, Wayne M   +5 more
core   +1 more source

Biomaterial-Based CRISPR/Cas9 Delivery Systems for Tumor Treatment

Mengmeng Li, Fenglei Chen, Qian Yang, Qinglai Tang, Z.Y. Xiao, Xinying Tong, Ying Zhang, Lanjie Lei, Shisheng Li   +8 more
openalex   +1 more source

Otimização de uma plataforma baseada na edição gênica por CRISPR/Cas9 para a produção de células T alogênicas expressando o receptor quimérico de antígeno (CAR) [PDF]

Sarah Caroline Gomes de Lima
openalex   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Multiplex CRISPR/Cas9-mediated editing of seven glycosyltransferase homologs in <i>Nicotiana benthamiana</i> to produce stable, Cas9-free, glycoengineered plants. [PDF]

Front Plant Sci
Kaur C, Song H, Lee M, Kim SY, Seo DH, Kang H, Sohn EJ, Ran Y, Koo O, Lee GJ.   +9 more
europepmc   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

CRISPR-Cas systems against carbapenem resistance: from proof-of-concept to clinical translation. [PDF]

Front Microbiol
Tsolakidou PJ.
europepmc   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Stage- and tissue-specific gene editing using 4-OHT-inducible Cas9 in whole organism. [PDF]

J Cell Biol
Li Y, Zhang W, Wei Z, Li H, Liu X, Zheng T, Aziz T, Xing C, Meng A, Wu X.   +9 more
europepmc   +1 more source