Results 271 to 280 of about 278,076 (329)

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

Advanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang, Wanyou Feng, Yanyan Yang, Yu Pan, Chaoxia Zou, Leyi Wang, Sanbao Zhang, Yimin Zhao, Yongmei Wu, Jinling Wang, Jianwei Zou, Kehe Cen, Yongwang Zhang, Han Huang, Yurong Xu, Li Zhong, Hailong Gong, Juanru Cheng, Jingyuan Liang, Zihua Zheng, Qinyang Jiang, Jingwei Wei, Hui Li, Minhui Liang, Deshun Shi, Sufang Yang, Yanfei Deng, Yingming Wei   +27 more
wiley   +1 more source

Compact bacterial recombination complexes drive efficient kilobase-scale knock-in in mammalian cells. [PDF]

Nucleic Acids Res
Luo Y, Jiang Q, Qu Y, Li W, Liu R, Zhu Y, Xie Y, Jiang C, Chen C, Cong L, Han F, Bao J, Wang C.   +12 more
europepmc   +1 more source

Generation of INS-jGCaMP7f knock-in Ca2+ reporter human embryonic stem cell line, GZLe001-C, using CRISPR/Cas9-based gene targeting

Xin Liu, Feng Zhang, Deqi Chen, Jiaxiang Yin, Zirong Bi, Lihua Chen, Jiawei Yan, Qifei Dong, Wei Peng, Tao Xu, Yanying Guo, Haopeng Lin, Huisheng Liu   +12 more
openalex   +1 more source

Generating polyploid millet through CRISPR/Cas9-mediated editing of the <italic>SiOSD1</italic> gene [PDF]

Yuqing Liang, Huimin Shen, Fengyue Hu, Chun Wang, Kejian Wang, Yong Huang, Zhirong Yang   +6 more
openalex   +1 more source

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

Advanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu, Ling Tang, Zheng Kuang, Danyi Huang, Ting Li, Gaofei Yin, Yingyu Chen, Wei Guo, Wenling Han, Pingzhang Wang   +9 more
wiley   +1 more source

RECC: A Red/ET-CRISPR/Cas9-based system enabling genome mining of marine <i>Pseudoalteromonas</i> for novel natural products. [PDF]

Synth Syst Biotechnol
Wang ZJ, Zhou H, Zhang Y, Yan F, Huo L, Wang X.   +5 more
europepmc   +1 more source

Metoder och tillämpningar av CRISPR-Cas9 i cancerforskning. : Samt hur CRISPR-Cas9 kan implementeras i skolundervisningen.

, 2020
Rodrigo Valladares, Hanna Briheim
openalex   +1 more source

HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration

Advanced Science, EarlyView.
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong, Ziyun Liang, Tianqi Duo, Liping Pan, Qi Zhu, Jiete Liang, Xianyao Luo, Qingcai Feng, Rong Xu, Yihao Liu, Xu Chen, Luxi Chen, Xiaohong Liu, Yaosheng Chen, Delin Mo   +14 more
wiley   +1 more source

AAV-mediated gene therapy for the CNS: The case for early treatment. [PDF]

Mol Ther Methods Clin Dev
Liebscher Vidal LE, Martinez-Navio JM.
europepmc   +1 more source