Results 271 to 280 of about 251,083 (336)

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Conditional Control of CRISPR/Cas9 Function by Chemically Modified Oligonucleotides. [PDF]

Molecules
Wang L, Liu Y, Song H, Zhang X, Wang Y.
europepmc   +1 more source

Faculty Opinions recommendation of Genome-scale CRISPR-Cas9 knockout screening in human cells.

, 2014
Stephan Beck
openalex   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, EarlyView.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source

Establishment of Cre/LoxP-mediated multifunctional reporter knock-in rats with the CRISPR system. [PDF]

PLoS One
Nakamura K, Ito S, Ohguchi Y, Jimbo T, Wada Y, Nakajima R, Kanou M, Yamana K, Ueda H.   +8 more
europepmc   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Mutation in soybean Lox-2 PLAT/LH2 domain through CRISPR/Cas9 reduces seed lipoxygenase activity: responsible for undesirable flavour. [PDF]

Transgenic Res
Patel E, Das P, Hazra S, Sharma M, Chhabra G, Gill BS, Sharma S, Kaur A, Singla D, Sandhu JS.   +9 more
europepmc   +1 more source

Faculty Opinions recommendation of CRISPR-Cas9 knockin mice for genome editing and cancer modeling.

, 2014
Vijay Tiwari, Angela Garding
openalex   +2 more sources

SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

Advanced Science, EarlyView.
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou, Yang Gu, Zhibin Yi, Jianyi Wang, Zhen Xiong, Hui Guo, Ying Du, Xiaoxiao Zhu, Lei He, Weizheng Ren, Yong Tian, Yanying Wang, Zusen Fan   +12 more
wiley   +1 more source

Developing a new cleavable crosslinker reagent for in-cell crosslinking. [PDF]

Commun Chem
Müller F, Brutiu BR, Saridakis I, Leischner T, Birklbauer MJ, Matzinger M, Madalinski M, Lendl T, Shaaban S, Dorfer V, Maulide N, Mechtler K.   +11 more
europepmc   +1 more source