Results 61 to 70 of about 1,452,828 (281)
Predictive Testing for Tumor Predisposition Syndromes in Pediatric Relatives: An Asian Experience
Frontiers in Pediatrics, 2020 Approximately 10% of pediatric cancer patients possess germline pathogenic/likely pathogenic variants (PV/LPV) in known tumor predisposition genes.
Jianbang Chiang +7 more
doaj +1 more source
Optimization of quantum cascade laser operation by geometric design of cascade active band in open and closed models [PDF]
, 2013 Using the effective mass and rectangular potential approximations, the theory of electron dynamic conductivity is developed for the plane multilayer resonance tunnel structure placed into a constant electric field within the model of open nanosystem, and
Boyko, I. V. +3 more
core +4 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Real-Time Observation of Target Search by the CRISPR Surveillance Complex Cascade
Cell Reports, 2017 CRISPR-Cas systems defend bacteria and archaea against infection by bacteriophage and other threats. The central component of these systems are surveillance complexes that use guide RNAs to bind specific regions of foreign nucleic acids, marking them for
Chaoyou Xue +4 more
doaj +1 more source
Dynamic anisotropy in MHD turbulence induced by mean magnetic field
, 2017 In this paper, we study the development of anisotropy in strong MHD turbulence in the presence of a large scale magnetic field B 0 by analyzing the results of direct numerical simulations.
Alexakis, Alexandros +3 more
core +1 more source
Syndemics and the PrEP Cascade: Results from a Sample of Young Latino Men Who Have Sex with Men. [PDF]
, 2019 Young Latino men who have sex with men (MSM) are a highly vulnerable population for HIV infection. Pre-exposure prophylaxis (PrEP) is a novel biomedical HIV prevention tool that may aid in reducing the disparity in HIV incidence among Latino MSM. However,
Blashill, Aaron J +8 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
A Theoretical Comparative Study of CO2 Cascade Refrigeration Systems
Applied Sciences, 2019 The objective of this work is the comparison of the different cascade refrigeration systems with CO2 in the low-temperature circuit. A total of 18 different cascade refrigeration systems are examined including the CO2/CO2 cascade system.
Evangelos Bellos, Christos Tzivanidis
doaj +1 more source
Cascading on extragalactic background light
, 2007 High-energy gamma-rays propagating in the intergalactic medium can interact with background infrared photons to produce e+e- pairs, resulting in the absorption of the intrinsic gamma-ray spectrum.
Aharonian +23 more
core +3 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source