Results 71 to 80 of about 297,562 (257)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Visible-light-induced radical cascade cyclization: a catalyst-free synthetic approach to trifluoromethylated heterocycles

Beilstein Journal of Organic Chemistry
A visible-light-promoted research protocol for constructing dihydropyrido[1,2-a]indolone skeletons is herein described proceeding through a cascade cyclization mediated by trifluoromethyl radicals.
Chuan Yang, Wei Shi, Jian Tian, Lin Guo, Yating Zhao, Wujiong Xia   +5 more
doaj   +1 more source

Cascade Reactions of Indigo with an Allenylic Reactant

Molecules
The base-enabled reaction of buta-2,3-dien-1-yl methanesulfonate with the readily available and cheap dye indigo resulted in the convenient one-pot synthesis of benzoindolonaphthyridinedione and benzoazepinopyridoindolediones, with the latter ...
Dyah U. C. Rahayu, Christopher Richardson, John B. Bremner, Paul A. Keller   +3 more
doaj   +1 more source

Evaporation of alpha particles from $^31$P nucleus

, 1998
The energy spectra of alpha particles have been measured in coincidence with the evaporation residues for the decay of the compound nucleus $^31$P produced in the reaction $^19$F (96 MeV) + $^12$C.
Bandyopadhyay, D., Basu, S. K., Bhattacharya, C., Bhattacharya, S., Chatterjee, A., Kailas, S., Krishan, K., Navin, A., Srivastava, A.   +8 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Parallel implementation of stochastic simulation for large-scale cellular processes [PDF]

, 2005
Experimental and theoretical studies have shown the importance of stochastic processes in genetic regulatory networks and cellular processes. Cellular networks and genetic circuits often involve small numbers of key proteins such as transcriptional ...
Burrage, K., Tian, T.
core   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The synthesis of functionalized bridged polycycles via C–H bond insertion

Beilstein Journal of Organic Chemistry, 2016
This review presents examples from the chemical literature of syntheses of bridged-polycyclic products via C–H bond insertion by carbenes and nitrenes.
Jiun-Le Shih, Po-An Chen, Jeremy A. May
doaj   +1 more source

Large enhancement of radiative strength for soft transisitons in the quasicontinuum

, 2004
Radiative strength functions (RSFs) for the 56,57-Fe nuclei below the separation energy are obtained from the 57-Fe(3-He,alpha gamma)56-Fe and 57-Fe(3-He,3-He' gamma)57-Fe reactions, respectively.
A. Schiller, A. Voinov, E. Algin, G. E. Mitchell, G. A. Bartholomew, J. Kopecky, J. Rekstad, M. Guttormsen, R. Chankova, S. Siem, S. G. Kadmenskiĭ, S. T. Boneva, S. T. Boneva, S. T. Boneva, S. T. Boneva, T. Belgya, T. Belgya, U. Agvaanluvsan, Yu. P. Popov   +18 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source