Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
A case-based reasoning system for neonatal survival and LOS prediction in neonatal intensive care units: a development and validation study. [PDF]
Sci Rep, 2023 Kermani F +3 more
europepmc +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Modification of Case-Based Reasoning Similarity Formula to Enhance the Performance of Smart System in Handling the Complaints of in vitro Fertilization Program Patients. [PDF]
Healthc Inform Res, 2022 Christianto PA, Sediyono E, Sembiring I.
europepmc +1 more source
Marc Jacob. Precedents and Case-based Reasoning in the European Court of Justice: Unfinished Business * Valeriane Konig. Prazedenzwirkung internationaler Schiedsspruche: Dogmatisch-empirische Analysen zur Handels- und Investitionsschiedsgerichtsbarkeit [The precedential effect of international arbitral awards: Doctrinal and empirical analyses of the Commercial and Investment Arbitration] [PDF]
, 2014 Nikolaj Petersen
openalex +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
ComputersModern custom machine construction and automation projects face pressure to shorten innovation cycles, reduce durations, and manage growing system complexity.
Roland Wölfle +2 more
doaj +1 more source
Case-Based Reasoning Application for Parking Guidance Systems
, 2022 Neyko Neykov, Svetlana Stefanova
openalex +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source