Results 41 to 50 of about 808,186 (314)

Health professions education cohort programs: A case study of pivoting from in‐person to online learning in cohort‐based programs [PDF]

, 2022
Wendy M. Green, Alexander Hoffman, Mariel Manlapaz, Cecile Foshee   +3 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Scaffolding medical student knowledge and skills: team-based learning (TBL) and case-based learning (CBL)

BMC Medical Education, 2021
Background Two established small-group learning paradigms in medical education include Case-based learning (CBL) and Team-based learning (TBL). Characteristics common to both pedagogies include the use of an authentic clinical case, active small-group ...
Annette Burgess, Elie Matar, Chris Roberts, Inam Haq, Lucy Wynter, Julian Singer, Eszter Kalman, Jane Bleasel   +7 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Enhancing active learning in microbiology through case based learning: Experiences from an Indian medical school

Indian Journal of Pathology and Microbiology, 2010
Background: Case-based learning (CBL) is an interactive student-centered exploration of real life situations. This paper describes the use of CBL as an educational strategy for promoting active learning in microbiology.
Ciraj A, Vinod P, Ramnarayan K
doaj  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Impact of comprehensive teaching mode and trainer experience on teaching effect of basic surgical skill training [PDF]

Jichu yixue yu linchuang, 2021
Objective To study the impact of comprehensive teaching mode and trainer experience on teaching effect of surgical basic technique training. Methods The present study adopted 2×2 factorial design. Seventy surgical interns were randomly assigned to
WANG Chang-jun, LIN Yan, ZHOU Yi-dong, ZHAO Jun, JIANG Ying-zi, LUO Lin-zhi, SUN Qiang
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Case-based learning paradigm: The role of gender program interface on knowledge acquisition process

Journal of Clinical Sciences, 2020
The effectiveness of any pedagogical method is reflected on learners perception of key elements involved in the process of knowledge acquisition. The adoption of case-based learning is asserted to deliver superior positive influence on how students ...
Abraham A. A. Osinubi, Leke Jacob Medubi, Adesoji Ademuyiwa, Oluseyi F Ajayi, Ihuoma A Igwilo, Daniel O Odebiyi, Mobolanle R Balogun, Tinuola O Odugbemi, Omolara Uti, Bosede Afolabi, Folashade T Ogunsola   +10 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source