Results 61 to 70 of about 34,810,201 (299)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Enhancing Inquiry-Based Learning Environments with the Power of Problem-Based Learning to Teach 21st Century Learning and Skills

, 2015
This chapter provides an outline of how the essential elements of Problem-based Learning (PBL) can be adapted to enhance inquiry-based learning environments and in the process teach 21st century skills. It uses a case study of a first year nursing course
Megan Y. C. A. Kek, Kek, Megan Y. C. A., Huijser, Henk, Ruth Terwijn, Terwijn, Ruth, Henk Huijser   +5 more
core   +1 more source

多元化教学模式在缺血性脑血管病介入进修医师培训中的应用探索 Exploration on Multi-Model Teaching in Neurointerventional Operation Training for Ischemic Cerebrovascular Disease

Zhongguo cuzhong zazhi
目的 探讨多元化教学模式在提高缺血性脑血管病介入诊疗进修医师培训质量和效率方面的应用。 方法 选择2018年1月—2022年12月在南京大学医学院附属鼓楼医院神经内科接受脑血管介入培训的进修医师为研究对象，应用多元化教学模式，即将多种教学方法融合交叉的培训模式进行教学。采用问卷调查的形式对进修医师满意度及其在培训前后介入诊疗理论知识和实践操作能力进行评估。 结果 共纳入55名进修医师，年龄32～50岁，其中男性51名（92.73%）。89.09%的进修医师对多元化教学模式非常满意；分别有83.64%
韩丽娟，张曦，陈志斌，金佳丽，王翀，徐运，李敬伟 (HAN Lijuan, ZHANG Xi, CHEN Zhibin, JIN Jiali, WANG Chong, XU Yun, LI Jingwei)
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The green economy learning assessment South Africa: Lessons for higher education, skills and work-based learning

, 2018
The purpose of this paper is to share and analyse the methodology and findings of the 2016 Green Economy Learning Assessment South Africa, including learning needs identified with reference to the competency framings of Scharmer (2009) and Wiek et al ...
Rosenberg, Eureta, Lotz-Sisitka, Heila, Ramsarup, Presha   +2 more
core   +1 more source

Meeting learners where they are: case presentations in remote pediatric critical care education

Frontiers in Pediatrics
As the burden of pediatric critical illness is heaviest in low- and middle-income countries (LMIC), educating trainees in recognizing and treating the sickest children may attenuate high mortality rates, morbidity and hospital length of stay.
Adeolu Aromolaran, Ruchit Nagar, Claudia Adja-Sai, Renee Alce, Tigist Bacha, Shitahun Fentie, Marie Charlyne Kilba, Sheendy Lilite, Brian S. Marcus, Marguereth Mehu, Aneso Mohammed, Uchenna Nnajekwu, Odiraa Nwankwor, Odiraa Nwankwor, Chiesonu Nzeduba, Larko Owusu, John Adabie Appiah, Frank Owusu-Sekeyre, Tagbo Oguonu, Priya Prabarkaran, Andrew Wu, Adam M. Silverman, Ayanaw Tamene, Charles Udemba, Bitseat W. Haile, Susan Zakariah, Michael F. Canarie   +26 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Designing Learning Services: From Content-based

, 2008
The need for e-learning systems that support a diverse set of pedagogical requirements has been identified as an important issue in web-based education.
To Activity-Based Learning
core  

Developing a case-based experiential learning model at a program level in a regional university : reflections on the developmental process [PDF]

, 2020
This article reflects on the developmental process of a case-based experiential learning model: the Federation University model, in an undergraduate community and human services program at a regional university.
Cooper, Kimberlea, Townsend, Rob, Patil, Tejaswini, Hunt, Michelle   +3 more
core