Results 41 to 50 of about 1,002,273 (313)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
User behaviour-driven group formation through case-based reasoning and clustering [PDF]
, 2012 Group formation for collaborative learning activities is a complex and time consuming task. Different criteria have been proposed for grouping learners in computer-based systems, such as performance and social characteristics. User behaviour is, however,
Cocea, Mihaela +2 more
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BMC Medical EducationBackground The seminar-case learning (SCL) model is a case-oriented teaching model, characterized by communication, interaction and mutual inspiration.
Jicheng Lou, Feng Guo
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Case-based learning in an electronic learning environment
, 2014 The benefits of e-learning have been widely established. These benefits include reduced costs, time savings, flexibility, accessible learning, and convenience.
Graham, John
core +1 more source
Journal of Emergencies, Trauma and Shock, 2018 INDUSEM was established as an INDO-US Satellite Knowledge Network in 2005. It brought together the academic leaders and innovators from India and the US with the goal of creating collaborative synergies and creative solutions to advance the knowledge and
Vivek Chauhan +7 more
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Zhongguo cuzhong zazhi目的 探讨多元化教学模式在提高缺血性脑血管病介入诊疗进修医师培训质量和效率方面的应用。 方法 选择2018年1月—2022年12月在南京大学医学院附属鼓楼医院神经内科接受脑血管介入培训的进修医师为研究对象，应用多元化教学模式，即将多种教学方法融合交叉的培训模式进行教学。采用问卷调查的形式对进修医师满意度及其在培训前后介入诊疗理论知识和实践操作能力进行评估。 结果 共纳入55名进修医师，年龄32～50岁，其中男性51名（92.73%）。89.09%的进修医师对多元化教学模式非常满意；分别有83.64%
韩丽娟，张曦，陈志斌，金佳丽，王翀，徐运，李敬伟 (HAN Lijuan, ZHANG Xi, CHEN Zhibin, JIN Jiali, WANG Chong, XU Yun, LI Jingwei)
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The comparison of the effect of traditional and off-line electronic educational methods on the knowledge and attitude of the undergraduate dental students of Shiraz University of Medical Sciences [PDF]
Interdisciplinary Journal of Virtual Learning in Medical Sciences, 2015 Introduction: E-learning as one of the new methods of learning makes it possible to achieve skills at higher levels without time and space constraints. The purpose of this research was to compare the effect of case-based learning in two ways of personal ...
Sara Karanjam +2 more
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