Results 51 to 60 of about 1,002,273 (313)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Intelligent control using generalizing case-based reasoning with neural networks [PDF]

, 2000
One model of human learning involves choosing an action based on past experiences in similar situations. The chosen action is typically modified to compensate for any discrepancies with the current situation. After sufficient experience has been obtained,
Babcock, David S.
core   +1 more source

CASE BASED LEARNING SEBAGAI UPAYA PENINGKATAN AKTIVITAS BELAJAR DAN KOMUNIKASI MATEMATIS

Aksioma: Jurnal Program Studi Pendidikan Matematika
Komunikasi matematis merupakan salah satu kemampuan yang harus dikuasai oleh mahasiswa. Melalui penguasaan komunikasi matematis yang baik, mahasiswa akan menyampaikan konsep-konsep matematika dengan baik dan benar.
Rahmad Bustanul Anwar, Dwi Rahmawati
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Does case-based blended-learning expedite the transfer of declarative knowledge to procedural knowledge in practice?

BMC Medical Education, 2019
Background Case-Based Learning (CBL) has seen widespread implementation in undergraduate education since the early 1920s. Ample data has shown CBL to be an enjoyable and motivational didactic tool, and effective in assisting the expansion of declarative ...
Bela Turk, Sebastian Ertl, Guoruey Wong, Patricia P. Wadowski, Henriette Löffler-Stastka   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Designing professional learning [PDF]

, 2014
The Designing Professional Learning report provides a snapshot of the key elements involved in creating effective and engaging professional learning in a globally dispersed market.
Learning Forward
core  

Qualitative case-based reasoning and learning

Artificial Intelligence, 2020
Paulo Eduardo Santos acknowledges support from FAPESP-IBM Proc. 2016/18792-9. Ramon Lopez de Mantaras has been partially supported by the Generalitat de Catalunya Grant number 2017 SGR 172, by the CSIC Grant PIE 201750E090, and by the European Project “HumanE-AI-Net” H2020-ICT-48-2020-RIA-952026.
Thiago Pedro Donadon Homem, Paulo Eduardo Santos, Anna Helena Reali Costa, Reinaldo Augusto da Costa Bianchi, Ramón López de Mántaras   +4 more
openaire   +3 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Case-based learning in collaboration across universities to enhance students' understanding of sustainability [PDF]

, 2023
Focus on sustainability is increasing in engineering and management education, businesses, and the larger society. In order to cope with sustainability challenges, more holistic pedagogies and practices that foster interdisciplinary and transdisciplinary
Eriksson, Victor, Holma, Anne-Maria, Lind, Frida   +2 more
core