Results 51 to 60 of about 34,810,201 (299)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Practice Based Learning Approaches in Collaborative Design and Engineering Education: A Case Study Investigation into the Benefits of a Crossdisciplinary Practice Based Learning Strategy

, 2012
This study explores the ongoing pedagogical development of a number of undergraduate design and engineering programmes in the United Kingdom. Observations and data have been collected over several cohorts to bring a valuable perspective to the approaches
Buck, Lyndon, McLening, Christian
core   +2 more sources

A three-dimensional clinical teaching model integrating CBL and PBL for ophthalmology clerkship in traditional Chinese and Western medicine

Frontiers in Medicine
BackgroundIntegrated traditional Chinese and Western medicine has shown clear advantages in the management of ophthalmic diseases. However, misalignment between traditional Chinese medicine syndrome differentiation and Western pathological classification,
Minghui Zhao, Juan Li, Jiali Liu, Yanyun Jiang, Rui Liu, Wei Zhou, Shaolin Du, Lixia Liu, Ligang Jiang   +8 more
doaj   +1 more source

Does case-based blended-learning expedite the transfer of declarative knowledge to procedural knowledge in practice?

BMC Medical Education, 2019
Background Case-Based Learning (CBL) has seen widespread implementation in undergraduate education since the early 1920s. Ample data has shown CBL to be an enjoyable and motivational didactic tool, and effective in assisting the expansion of declarative ...
Bela Turk, Sebastian Ertl, Guoruey Wong, Patricia P. Wadowski, Henriette Löffler-Stastka   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nursing Students’ Views and Suggestions About Case-Based Learning Integrated Into the Nursing Process: A Qualitative Study [PDF]

, 2021
AIM: This study aimed to evaluate students’ views and suggestions about case-based learning. METHOD: : The research was planned by using qualitative method of phenomenological type.
Rukiye Burucu, Burucu, Rukiye, Arslan, Selda, Selda Arslan   +3 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Qualitative case-based reasoning and learning

Artificial Intelligence, 2020
Paulo Eduardo Santos acknowledges support from FAPESP-IBM Proc. 2016/18792-9. Ramon Lopez de Mantaras has been partially supported by the Generalitat de Catalunya Grant number 2017 SGR 172, by the CSIC Grant PIE 201750E090, and by the European Project “HumanE-AI-Net” H2020-ICT-48-2020-RIA-952026.
Thiago Pedro Donadon Homem, Paulo Eduardo Santos, Anna Helena Reali Costa, Reinaldo Augusto da Costa Bianchi, Ramón López de Mántaras   +4 more
openaire   +4 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source