Results 221 to 230 of about 135,908 (286)

Reframing Wnt/β‐Catenin Signalling in Liver Fibrosis: Transcriptional State Regulation by CBP and p300

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Liver fibrosis is a shared pathological phenotype of chronic liver diseases of diverse etiologies, including viral hepatitis, alcohol‐associated liver disease and metabolic dysfunction–associated steatohepatitis (MASH), as well as cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis, and may ...
Kiminori Kimura, Michinori Kohara
wiley   +1 more source

Retinoic Acid‐Related Orphan Nuclear Receptor Alpha Promotes Cartilage Degeneration in Osteoarthritis by Activating the Wnt/β‐Catenin Pathway

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu, Tianwei He, Jiawei Di, Lang Mai, Depeng Wu, Mudan Huang, Yankui Liu, Zhongyu Liu, Liangming Zhang, Lei He   +9 more
wiley   +1 more source

Correction: Wang et al. Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling. <i>Int. J. Mol. Sci.</i> 2023, <i>24</i>, 7034. [PDF]

Int J Mol Sci
Wang B, Zhang J, Zhang D, Lu C, Liu H, Gao Q, Niu T, Yin M, Cui S.   +8 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Psychological Stress Increases the Expression of Milk-Derived miR-210-5p. [PDF]

J Mammary Gland Biol Neoplasia
Chiba T, Fujisawa M, Maeda T.
europepmc   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, Volume 13, Issue 31, 4 June 2026.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

A Four-Wavelength Flow-Through Fluorescence-Scatterometric Sensor That Allows for Real-Time Determination of Fat and Protein Content in Milk-Air Mixtures with High Accuracy. [PDF]

Sensors (Basel)
Astashev ME, Ignatenko DN, Molkova EA, Gogolev IM, Onegov AV, Smolentsev SY, Khakimov AR, Ruzin SS, Budnikov DA, Pavkin DY, Gudkov SV.   +10 more
europepmc   +1 more source

CRISPR/Cas9-mediated targeted knock-in of human erythropoietin at the β-casein locus results in lactogenic hormone-responsive expression in HC11 mammary epithelial cells. [PDF]

Sci Rep
You HJ, Kim GY, Kang MJ.
europepmc   +1 more source

Genome Sequencing in 19 Families With Bladder Exstrophy and Epispadias Complex Indicates Involvement of the ADGR ‐Gene Family

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1286-1305, June 2026.
ABSTRACT Bladder exstrophy and epispadias complex (BEEC) is one of the most severe congenital malformations of the urogenital tract, significantly impacting continence, sexual function, and renal function. To date, the only recurrent genetic aberration identified is the 22q.11.2 microduplication, but several candidate regions and genes including ...
Agneta Nordenskjöld, Samara Alm, Jesper Eisfeldt, Jia Cao, Magnus Anderberg, Gillian Barker, Hans Matsson, Gundela Holmdahl, Anna Lindstrand, Kristina Lagerstedt‐Robinson   +9 more
wiley   +1 more source