Results 101 to 110 of about 4,588 (199)

Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixed-species malaria in Gabon [PDF]

, 2012
Background: The recommendation of artemisinin combination therapy (ACT) as first-line treatment for uncomplicated falciparum malaria is supported by a plethora of high quality clinical trials.
Adegnika, Ayola A., Basra, Arti, Bélard, Sabine, Capan, Mesküre, Diop, Daisy A., Joanny, Fanny, Kleine, Christian, Kremsner, Peter G., Kurth, Florian, Mombo-Ngoma, Ghyslain, Mordmüller, Benjamin, Ramharter, Michael, Würbel, Heike   +12 more
core   +1 more source

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source

Chemical Characterization, Antioxidant and Enzymatic Activity of Brines from Scandinavian Marinated Herring Products [PDF]

, 2014
Brines generated during the last marination step in the production of marinated herring (Clupea harengus) were chemically characterized and analyzed for antioxidant and enzyme activities.
Baron, Caroline P., Gringer, Nina, Nielsen, Henrik Hauch, Osman, Ali, Undeland, Ingrid   +4 more
core   +1 more source

Dysregulated Fatty Acid Metabolism in Preeclampsia Among Highland Andeans: Insights Into Adaptive and Maladaptive Placental Metabolic Phenotypes

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
Multi‐omic profiling of highland Andeans reveals adaptive fetal haplotypes associated with favorable placental metabolic phenotypes, while preeclampsia is marked by dysregulated fatty acid oxidation and acylcarnitine accumulation across maternal‐placental‐fetal compartments. Metabolomic profiling showed widespread accumulation of medium‐ and long‐chain
Katie A. O'Brien, Lilian Toledo‐Jaldin, Wanjun Gu, Julie A. Houck, Litzi Lazo‐Vega, Valquiria Miranda‐Garrido, Hong W. Yung, Hussna Yasini, Lorna G. Moore, Julie A. Reisz, Tatum S. Simonson, Jonathan Shortt, Margaret Stalker, Angelo D'Alessandro, Colleen G. Julian   +14 more
wiley   +1 more source

Extraction, purification, and activity of protease from the leaves of Moringa oleifera [version 1; referees: 2 approved, 1 approved with reservations]

F1000Research, 2018
Background: Proteases cleave proteins, thereby providing essential amino acids for protein synthesis, and degrade misfolded and damaged proteins to maintain homeostasis.
Swarnali Banik, Shrutidhara Biswas, Srabani Karmakar   +2 more
doaj   +1 more source

Mucosal immunization with caseinolytic protease X elicited cross-protective immunity against pneumococcal infection in mice

Experimental Biology and Medicine, 2012
Streptococcus pneumoniae resides on the mucosal surface of the upper respiratory tract and is ready to spread and trigger clinical diseases. Hence the vaccine that can eliminate the nasopharyngeal colonization was thought to be an ideal protective strategy against pneumococcal invasive diseases.
Wen, Zhong, Wenchun, Xu, Hong, Wang, Yuanshuai, Huang, Ju, Cao, Yi, Gong, Xiuyu, Xu, Xun, Min, Yanqing, Zhang, Jie, Dong, Yibing, Yin, Xuemei, Zhang   +11 more
openaire   +2 more sources

Assessing Cytochrome P450 Drug Interaction Risk for Dordaviprone Using Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1695-1704, October 2025.
ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal, Nikunjkumar K. Patel, Hannah M. Jones, Savannah McFeely, Shamia L. Faison, Tim Tippin, Odin Naderer   +6 more
wiley   +1 more source

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase. [PDF]

, 2019
Bacterial ClpB and yeast Hsp104 are homologous Hsp100 protein disaggregases that serve critical functions in proteostasis by solubilizing protein aggregates.
Bart, Stephen M, Castellano, Laura M, DiMaio, Frank, Gates, Stephanie N, Lin, JiaBei, Rizo, Alexandrea N, Shorter, James, Southworth, Daniel R, Tse, Eric   +8 more
core  

The effect of an emollient containing urea, ceramide NP, and lactate on skin barrier structure and function in older people with dry skin [PDF]

, 2016
Xerosis affects up to 75% of older people and develops as a result of a skin barrier defect. Emollients are widely used to treat xerosis; however, there is limited understanding of the differences between them and their effects on the skin barrier in ...
Albenali, L., Brown, K., Chittock, J., Cork, M., Danby, S.G., Higgs-Bayliss, T.   +5 more
core   +2 more sources

Inhibitory Effect of Amentoflavone on the Virulence of MRSA by Targeting ClpP

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Methicillin‐resistant Staphylococcus aureus (MRSA) poses significant therapeutic challenges due to its global spread and virulence. Targeting the critical virulence regulator ClpP presents a promising antivirulence strategy. This study investigated AMF's mechanism against MRSA through molecular dynamics simulations, FRET and TSA.
Teri Gele, Xiangri Kong, Qiuyue Zhang, Wu Song, Junpeng Guo, Paizati Hamidi, Kulishasi Mani, Shaoyu Han, Xuan Zhao, Jingwen Chen, Chi Zhang, Abduldayeva Aigul Abduldayevna, Qingjie Li   +12 more
wiley   +1 more source