Results 141 to 150 of about 10,081 (262)

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

open access: yesThe FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels   +7 more
wiley   +1 more source

Laser-based mid-IR spectroscopy as a rapid analytical technique for the quantification of human milk proteins. [PDF]

open access: yesCurr Res Food Sci
Ten-Doménech I   +12 more
europepmc   +1 more source

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

open access: yesThe FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast   +3 more
wiley   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

open access: yesThe FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath   +2 more
wiley   +1 more source

Online Coupling of Field-Flow Fractionation with Raman Microspectroscopy Enables the Advanced Study of Nanoplastics Directly in Food. [PDF]

open access: yesAnal Chem
Giordani S   +7 more
europepmc   +1 more source

Disorder in Milk Proteins: Caseins, Intrinsically Disordered Colloids

open access: yes, 2015
This article opens a series of reviews on the abundance and roles of intrinsic disorder in milk proteins. The focus of this introductory article on caseins is symbolic, since caseins were among the first recognized functional unfolded proteins and since ...
Uversky, Vladimir N.   +3 more
core  

Efficacy of Dental Varnishes and Gels for the Prevention and Management of Dental Caries in Older Adults—A Systematic Review and Meta‐Analysis

open access: yesGerodontology, EarlyView.
ABSTRACT Introduction To evaluate the efficacy of dental varnishes/gels in the prevention/management of dental caries in older adults. Methods Cochrane, PubMed, Web of Science and EMBASE were searched through March 2024 for randomized controlled trials (RCT) including patients aged ≥ 60 years (or average age ≥ 60 years) utilizing varnish or gel ...
Theresa Cleary   +3 more
wiley   +1 more source

Sorbitol modulates the structure and nanomechanics of κ-casein amyloid fibrils. [PDF]

open access: yesBiophys J
Rahimi N   +11 more
europepmc   +1 more source

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