Results 241 to 250 of about 341,145 (337)

Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD. [PDF]

J Inflamm Res
Li Z, Cao S, Yang J, Chen L, Jia L, Lu P, Liu J, Liu M, Liu Q.   +8 more
europepmc   +1 more source

Interferon γ inhibits growth of human pancreatic carcinoma cells via caspase-1 dependent induction of apoptosis [PDF]

, 2001
Katharina Detjen, Katrin Farwig, Martina Welzel, Bertram Wiedenmann, Stefan Rosewicz   +4 more
openalex   +1 more source

HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer

Advanced Science, EarlyView.
This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su, Yang Wang, Xifeng Qin, Yaqiong Xiao, Boshu Ouyang, Lina Hu, Lin Kang, Ruizhe Xu, Ce Xu, Zanya Sun, Chenyu Sun, Huishu Guo, Zhiqing Pang, Shun Shen   +13 more
wiley   +1 more source

Mitigation of sepsis-induced liver injury by Clemastine via modulating GSDMD/NLRP-3/Caspase-1/NF-κB signalling pathways. [PDF]

Eur J Med Res
Abdelnaser M, Attya ME, El-Rehany MA, Fathy M.   +3 more
europepmc   +1 more source

Caspase-9 Activation Results in Downstream Caspase-8 Activation and Bid Cleavage in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease [PDF]

, 2001
Veena Viswanath, Yongqin Wu, Rapee Boonplueang, Sylvia Chen, Fang Feng Stevenson, Ferda Yantiri, Lichuan Yang, M. Flint Beal, Julie K. Andersen   +8 more
openalex   +1 more source

The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation

Advanced Science, EarlyView.
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng   +16 more
wiley   +1 more source

The MFGE8/integrin β3 axis mitigates experimental neutrophilic asthma by suppressing NLRP3-Caspase-1 pathway-mediated NETosis. [PDF]

Respir Res
Wang S, Kun T, Tian Z, Huang M, Fan Y, Li B, Zheng H, Xu R, Wang M, Zhao J, Xie J.   +10 more
europepmc   +1 more source

Impaired IL-18 processing protects caspase-1–deficient mice from ischemic acute renal failure [PDF]

, 2001
Vyacheslav Y. Melnikov, Tevfik Ecder, Giamila Fantuzzi, Britta Siegmund, M. Scott Lucia, Charles A. Dinarello, Robert W. Schrier, Charles L. Edelstein   +7 more
openalex   +1 more source

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source

The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor. [PDF]

Int J Mol Sci
Otani K, Komatsu R, Noguchi T, Suzuki W, Hirata Y, Matsuzawa A.   +5 more
europepmc   +1 more source