Results 241 to 250 of about 24,095,126 (372)

The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor. [PDF]

Int J Mol Sci
Otani K, Komatsu R, Noguchi T, Suzuki W, Hirata Y, Matsuzawa A.   +5 more
europepmc   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

A new type of Caspase-1 upon recognizing bacteria inhibits GSDME-dependent histone modification and NF-κB signaling. [PDF]

Commun Biol
Chang R, Sun J, Leng J, Wang Z, Mu S, Li Y, Wang J, Song L.   +7 more
europepmc   +1 more source

Chlamydia trachomatis Infection of Epithelial Cells Induces the Activation of Caspase-1 and Release of Mature IL-18 [PDF]

, 2000
Hang Lu, Caixia Shen, Robert C. Brunham
openalex   +1 more source

A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma

Advanced Science, EarlyView.
This study utilizes patient‐derived osteosarcoma organoids and CRISPR screening to identify ERCC6 and HNRNPM as key mediators of cisplatin resistance via the PI3K/AKT pathway and BAX alternative splicing. These findings provide novel insights and potential therapeutic targets for overcoming chemoresistance in osteosarcoma.
Ruiling Xu, Sai Zhu, Wenchao Zhang, Haodong Xu, Chao Tu, Honghui Wang, Lu Wang, Na He, Tang Liu, Xiaoning Guo, Xiaolei Ren, Zhihong Li   +11 more
wiley   +1 more source

Benzo[a]pyrene aggravated ovalbumin‑induced epithelial tight junction disruption via ROS driven‑NLRP3/Caspase‑1 signaling pathway in asthmatic mice. [PDF]

Int J Mol Med
Xu Y, Feng Y, Wang L, Xu X, Xu L, Wang B.   +5 more
europepmc   +1 more source

CASPASES -2, -3, -6, AND -9, BUT NOT CASPASE-1, ARE ACTIVATED IN SEPSIS-INDUCED THYMOCYTE APOPTOSIS

, 2000
Kevin W. Tinsley, Shan Cheng, Timothy G. Buchman, Kathleen C. Chang, Jia Ji Hui, Paul E. Swanson, Irene E. Karl, Richard S. Hotchkiss   +7 more
openalex   +1 more source

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis.

Nature Chemical Biology, 2017
Marian C. Okondo, Darren C. Johnson, Ramya Sridharan, Eun Bin Go, Ashley J. Chui, Mitchell S. Wang, Sarah E. Poplawski, Wengen Wu, Yuxin Liu, J. Lai, D. Sanford, Michael O Arciprete, T. Golub, W. Bachovchin, D. Bachovchin   +14 more
semanticscholar   +1 more source

Bacteroides Fragilis‐Derived Outer Membrane Vesicles Deliver MiR‐5119 and Alleviate Colitis by Targeting PD‐L1 to Inhibit GSDMD‐Mediated Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Bacteroides fragilis‐derived outer membrane vesicles deliver miR‐5119 and alleviate colitis by targeting PD‐L1 to inhibit GSDMD‐mediated neutrophil extracellular trap formation. Abstract Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system.
Yi Yang, Lanmengxi Yang, Yilin Yang, Haiyi Deng, Shiyu Su, Yinxiao Xia, Jin Su, Yuheng Liu, Junwei Wu, Jing Zhang, Yao Liao, Lifu Wang   +11 more
wiley   +1 more source

Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia. [PDF]

PLoS Pathog
Luo Q, Shen L, Yang S, Zhang Y, Pan Y, Wu Z, Shu Q, Chen Q.   +7 more
europepmc   +1 more source