Results 281 to 290 of about 318,537 (297)

Plaguing Caspase-1 Through Rac

Science's STKE, 2004
The Yersinia bacteria, whose most notorious member ( Y. pestis ) is the organism that causes bubonic plague, inject Yop proteins into target cells. The individual Yop effectors, which cooperate to prevent phagocytosis and suppress the inflammatory response, have highly specific effects.
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Obesity development in caspase-1-deficient mice

International Journal of Obesity, 2013
Caspase-1 is a member of the intracellular cysteine protease family that mediates inflammation through the activation of the cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18). As mice lacking IL-18 become obese and insulin resistant, and both IL-18 and IL-1β have a role in overall energy balance, we sought to determine whether caspase-1 ...
H, Wang, W, Capell, J H, Yoon, S, Faubel, R H, Eckel   +4 more
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The intricate biophysical puzzle of caspase-1 activation

Archives of Biochemistry and Biophysics, 2021
This review takes a closer look at the structural components of the molecules involved in the processes leading to caspase-1 activation. Interleukins 1β and 18 (IL-1β, IL-18) are well-known proinflammatory cytokines that are produced following cleavage of their respective precursor proteins by the cysteine protease caspase-1.
Nyasha J. Makoni, Michael R. Nichols
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Nucleotide Sequence of Equine Caspase-1 cDNA

DNA Sequence, 1999
Caspases are a family of cysteine proteases which have important roles in activation of cytokines and in apoptosis. Caspase-1, or interleukin-1 beta converting enzyme (ICE), promotes maturation of interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides.
S, Wardlow, M N, Penha-Goncalves, D J, Argyle, D E, Onions, L, Nicolson   +4 more
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A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones

Bioorganic & Medicinal Chemistry, 1999
We have evaluated 619 aspartic ketones with 9 different types of prime-side groups (acyloxymethyl, aryloxymethyl, arylthiomethyl, alkylthiomethyl, acylamino-oxymethyl, sulfonylaminomethyl, alpha-ketoamide, alpha-(1-phenyl-3-trifluoromethyl-pyrazol-5-yl)oxymethyl (PTP), and aliphatic ketones) as inhibitors of caspase-1. The inhibitory behaviors could be
K D, Brady, D A, Giegel, C, Grinnell, E, Lunney, R V, Talanian, W, Wong, N, Walker   +6 more
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Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Caspase-1-Dependent Pyroptosis in Murine J774 Macrophages

Inflammation, 2012
Sevoflurane is one of the most commonly used volatile anesthetics. Recent studies have shown that sevoflurane plays an important role in modulation of inflammation and immunity. However, little is known about the related molecular mechanisms. This study was designed to investigate the effects and mechanisms of sevoflurane on inflammatory cell death ...
Yue, Jin, Hui, Li, Guohao, Xie, Shuzhen, Chen, Shuijin, Wu, Xiangming, Fang   +5 more
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Caspase-1: an integral regulator of innate immunity

Seminars in Immunopathology, 2015
Caspase-1 is a unique cysteine protease playing central roles in innate immunity. Pathogens, stress, and damage signals induce activation of caspase-1, typically mediated by proximity-induced autoproteolysis in multimeric protein complexes called the inflammasome. Active caspase-1 induces secretion of pro-inflammatory cytokines and mediates pyroptosis,
Stefan, Winkler, Angela, Rösen-Wolff
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Quantifying Caspase-1 Activity in Murine Macrophages

2018
The caspase-1 protease is a core component of multiprotein inflammasome complexes, which play a critical role in regulating the secretion of mature, bioactive pro-inflammatory cytokines interleukin (IL)-1β and IL-18. The activity of caspase-1 is often measured indirectly, by monitoring cleavage of cellular caspase-1 substrates, processing of caspase-1 ...
Boucher, Dave, Chan, Amy, Ross, Connie, Schroder, Kate   +3 more
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Role of Caspase‐1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase‐1‐deficient mice

Annals of Neurology, 2002
AbstractCaspase 1 plays a pivotal role in generating mature cytokine interleukin‐1β. Interleukin‐1β is implicated as a mediator of pneumococcal meningitis, both in experimental models and in humans. We demonstrated here that (1) Caspase 1 mRNA and protein expression is upregulated in the brain during experimental pneumococcal meningitis, and (2 ...
Uwe, Koedel, Frank, Winkler, Barbara, Angele, Adriano, Fontana, Richard A, Flavell, Hans-Walter, Pfister   +5 more
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Immunohistochemical investigation of caspase-1 and effect of caspase-1 inhibitor in delayed neuronal death after transient cerebral ischemia

Brain Research, 2001
The localization of caspase-1 protein, interleukin-1beta (IL-1beta)-converting enzyme, was immunohistochemically examined in the hippocampal CA-1 subfield by a transient occlusion of bilateral common carotid arteries in Mongolian gerbils. Immunoreactivities for caspase-1 were found in microglias, astrocytes, endothelial cells of capillaries and some ...
Y, Hayashi, I, Jikihara, T, Yagi, M, Fukumura, Y, Ohashi, Y, Ohta, H, Takagi, M, Maeda   +7 more
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