Results 291 to 300 of about 24,095,126 (372)

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

The Effects of Xialiqi Capsules in Regulating the Pyroptosis of Prostate Epithelial Cells Via NLRP3/Caspase-1 Pathway for the Treatment of Chronic Prostatitis. [PDF]

Am J Mens Health
Hong Z, Chen Z, Chen W, Qiu J, Wang S, Wei Y, Guo J.   +6 more
europepmc   +1 more source

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion

Cell Death and Differentiation, 2016
Stephanie A Conos, Kate E. Lawlor, Kate E. Lawlor, D. Vaux, D. Vaux, J. Vince, J. Vince, Lisa M. Lindqvist, Lisa M. Lindqvist   +8 more
semanticscholar   +1 more source

Parvalbumin Interneuron‐Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker

Advanced Science, EarlyView.
This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan, Yunxuan Wang, Xufan Deng, Shiyu Wu, Yifan Pan, Jun Du, Mei Yu, Bo Liu, Huimei Wang, Zhengyu Zhang, Jinghong Chen, Shuifa Chen, Yizheng Wang, Tara Walker, Perry Bartlett, Jun Ju, Sheng‐Tao Hou   +16 more
wiley   +1 more source

Detection of NLRP3, ASC, and Caspase-1 in serum and cerebrospinal fluid of traumatic brain injury patients: implications for short-term prognosis. [PDF]

Acta Neurol Belg
Aihemaitiniyazi A, Ma K, Xu J, Chen H, Liu X, Li J.   +5 more
europepmc   +1 more source

Local Visible‐Photocatalytic Production of Hydrogen and Warm Heat for Combination Treatment of Pressure Ulcer

Advanced Science, EarlyView.
A novel concept of visible‐photocatalytic hydrogen/warm heat production is proposed for combination treatment of pressure ulcer (PU), and develop a new kind of palladium nanodots‐deposited hydrogen‐doped titanium dioxide nanorods encapsulating hydorgel dressing to receive a high outcome of PU treatment by hydrogen/warm heat synergistically improving ...
Jiawei Zhu, Ting Chen, Wei Fang, Di Zhou, Dalong Ni, Bin Zhao, Yali Yang, Zhuobin Xu, Qianjun He   +8 more
wiley   +1 more source

Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata. [PDF]

Biomol Biomed
Zhang J, Li Z, Liu K, Du X, Yao T, Ye J.
europepmc   +1 more source

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

Caspase-1-dependent pyroptosis converts αSMA⁺ CAFs into collagen-III^high iCAFs to fuel chemoresistant cancer stem cells. [PDF]

Sci Adv
Gao H, Wong SQR, Subel E, Huang YH, Lee YC, Hayashi K, Alonzo ME, Karabicici M, Hoi XP, Kasabyan A, Mo Q, Melchiode Z, El-Zaatari Z, Shen S, Satkunasivam R, Nikolos F, Chan KS.   +16 more
europepmc   +1 more source

Expression and activity of caspases 1 and 3 in myelodysplastic syndromes

, 2000
Delphine Boudard, Olivier Sordet, C. Vasselon, Valérie Revol, M. F. Bertheas, Damien Freyssenet, Annie Viallet, S PISELLI, Denis Guyotat, Lydia Campos   +9 more
openalex   +1 more source