Emerging roles of caspase-3 in apoptosis [PDF]
Cell Death & Differentiation, 1999 Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death protease, catalyzing the specific cleavage of many key cellular proteins. However, the specific requirements of this (or any other) caspase in apoptosis have remained largely unknown until now. Pathways to caspase-3 activation have
A. Porter, R. Jänicke
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Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival [PDF]
Apoptosis, 2016 Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis.
X. Pu +6 more
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Apoptosis Regulators Bcl-2 and Caspase-3
Encyclopedia, 2022 Apoptosis, programmed cell death, has a central role in developmental biology and in maintaining the equilibrium of renewing tissues. A founding member of the Bcl-2 family of regulatory proteins for apoptosis is Bcl-2, which is encoded by the BCL2 gene ...
Piret Hussar
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Apoptosis in prostate carcinoma tissue: The role of caspase-3, caspase-1, and alkaline DNase activity [PDF]
Journal of Medical BiochemistryBackground: Prostate glandular tissue maintains a delicate balance between cellular proliferation and programmed cell death (apoptosis), ensuring the preservation of normal glandular architecture in healthy individuals.
Veljkovic Andrej +6 more
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Immunohistochemical Expression of Caspase-3 in Psoriasis [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Psoriasis is a persistent chronic immune-mediated, relapsing, inflammatory and hyper proliferative skin disorder with genetic predisposition.
Shaimaa M.M. Bebars +3 more
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Caspase-3 Colorimetric Assay [PDF]
BioTechniques, 2002 Lizhi Zeng, Larry D. Smith
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Enhanced Expression of Caspase-3 in Hypertrophic Scars and Keloid: Induction of Caspase-3 and Apoptosis in Keloid Fibroblasts In Vitro [PDF]
Laboratory Investigation, 2000 Recent studies have suggested that the regulation of apoptosis during wound healing is important in scar establishment and development of pathological scarring. To examine the phenomenon of apoptosis and its involvement in the process of pathological scarring, we immunohistochemically quantified differential levels of expression of caspase-3 and -2 ...
Yoshikiyo Akasaka +8 more
openalex +4 more sources
Caspase-3 promotes genetic instability and carcinogenesis. [PDF]
Molecular Cell, 2015 Apoptosis is typically considered an anti-oncogenic process since caspase activation can promote the elimination of genetically unstable or damaged cells. We report that a central effector of apoptosis, caspase-3, facilitates rather than suppresses chemical- and radiation-induced genetic instability and carcinogenesis.
Xinjian Liu +6 more
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Air-Exposure- and Reoxygenation-Stimulated Expressions of Caspase-3 and Induction of Apoptosis in the Central Nervous System of the Crab Erimacrus isenbeckii [PDF]
CellsAir exposure stress during live transport and subsequent reoxygenation are factors in the development of molecular/pathological and compensatory/adaptive responses.
Elena Kotsyuba, Vyacheslav Dyachuk
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Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis
Journal of Cell Biology, 2022 Eskandari and Eaves review evidence of caspase-3-regulated protein quality, proliferation, differentiation, and tumorigenic activity in viable cells.
E. Eskandari, C. Eaves
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