Results 11 to 20 of about 16,586,228 (338)
Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival [PDF]
Apoptosis, 2016 Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis.
X. Pu +6 more
semanticscholar +5 more sources
Immunohistochemical Expression of Caspase-3 in Psoriasis [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Psoriasis is a persistent chronic immune-mediated, relapsing, inflammatory and hyper proliferative skin disorder with genetic predisposition.
Shaimaa M.M. Bebars +3 more
doaj +4 more sources
Caspase-3 Colorimetric Assay [PDF]
BioTechniques, 2002 Lizhi Zeng, Larry D. Smith
doaj +3 more sources
Emerging roles of caspase-3 in apoptosis [PDF]
Cell Death & Differentiation, 1999 Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death protease, catalyzing the specific cleavage of many key cellular proteins. However, the specific requirements of this (or any other) caspase in apoptosis have remained largely unknown until now. Pathways to caspase-3 activation have
A. Porter, R. Jänicke
semanticscholar +4 more sources
Apoptosis in the absence of caspase 3 [PDF]
Oncogene, 2001 MCF-7 human breast cancer cells do not express caspase 3, thought by some to be a critical component of the apoptosis cascade. Nonetheless, both mock- and bcl-2-transfected MCF-7 cells undergo apoptosis after treatment with a variety of stimuli, including the DNA-cleaving antimitotic agent, neocarzinostatin (NCS).
Ye Liang, Nina F. Schor, Chaohua Yan
openaire +3 more sources
Metalloporphyrins inactivate caspase‐3 and ‐8 [PDF]
The FASEB Journal, 2005 Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in vitro settings.
Alexandra K. Kiemer +9 more
openaire +4 more sources
Molecular Dynamics Studies of Caspase-3 [PDF]
Biophysical Journal, 2003 Caspase-3 is a fundamental target for pharmaceutical interventions against a variety of diseases involving disregulated apoptosis. The enzyme is active as a dimer with two symmetry-related active sites, each featuring a Cys-His catalytic dyad and a selectivity loop, which recognizes the characteristic DEVD pattern of the substrate.
Ursula Rothlisberger +2 more
openaire +3 more sources
Tau and Caspase 3 as Targets for Neuroprotection [PDF]
International Journal of Alzheimer's Disease, 2012 The peptide drug candidate NAP (davunetide) has demonstrated protective effects in variousin vivoandin vitromodels of neurodegeneration. NAP was shown to reduce tau hyperphosphorylation as well as to prevent caspase-3 activation and cytochrome-3 release from mitochondria, both characteristic of apoptotic cell death. Recent studies suggest that caspases
Anat Idan-Feldman +2 more
openaire +3 more sources
ACS Chemical Biology, 2021 Caspases are a family of enzymes that regulate biological processes such as inflammation and programmed cell death, through proteolysis. For example, in the intrinsic pathway of apoptosis, cell death signaling involves cytochrome c release from the ...
L. E. Araya +3 more
semanticscholar +1 more source
The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer
Cell Death Discovery, 2020 Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit cells proliferation.
Mingxia Jiang +3 more
semanticscholar +1 more source