Results 11 to 20 of about 460,615 (302)
Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival [PDF]
Apoptosis, 2016 Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis.
A Sangawa +49 more
core +6 more sources
Immunohistochemical Expression of Caspase-3 in Psoriasis [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Psoriasis is a persistent chronic immune-mediated, relapsing, inflammatory and hyper proliferative skin disorder with genetic predisposition.
Shaimaa M.M. Bebars +3 more
doaj +3 more sources
Caspase-3 Colorimetric Assay [PDF]
BioTechniques, 2002 Lizhi Zeng, Larry D. Smith
doaj +3 more sources
Huntingtin inhibits caspase‐3 activation [PDF]
The EMBO Journal, 2006 Huntington's disease results from a mutation in the HD gene encoding for the protein huntingtin. The function of huntingtin, although beginning to be elucidated, remains largely unclear. To probe the prosurvival function of huntingtin, we modulate levels of wild-type huntingtin in a number of cellular and in vivo models.
Yu, Zhang +7 more
openaire +2 more sources
Molecular Dynamics Studies of Caspase-3 [PDF]
Biophysical Journal, 2003 Caspase-3 is a fundamental target for pharmaceutical interventions against a variety of diseases involving disregulated apoptosis. The enzyme is active as a dimer with two symmetry-related active sites, each featuring a Cys-His catalytic dyad and a selectivity loop, which recognizes the characteristic DEVD pattern of the substrate.
Sulpizi, M. +2 more
openaire +2 more sources
Virology Journal, 2012 Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme +11 more
doaj +1 more source
Controlling TRAIL-mediated caspase-3 activation [PDF]
Leukemia, 2004 This commentary is addressed at the paper by Dr Jie and his co-workers in the current issue of Leukemia (‘Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells’). In this paper, the authors show the preferential use of Bax over Bak for the induction of mitochondrial apoptotic events in leukemic cell exposed to TRAIL 1.
Micheau, Olivier, Mérino, Delphine
openaire +2 more sources
Beneficial role of allicin from garlic in cervical cancer [PDF]
, 2008 Introduction: Cervical cancer remains a global health concern for females. Thus, in order to control cervical cancer, attempts are being made by researchers globally to somehow induce programmed cell death in the said cancerous cells.
Irfan Ahmad Ansari, Najmul Islam
core +2 more sources
Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3 [PDF]
, 2010 The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms
A. Maldonado-Contreras +28 more
core +1 more source
Caspase-3 joins the p53 interactome [PDF]
Cancer Biology & Therapy, 2011 Commentary to: Wild-type and mutant p53 proteins interact with mitochondrial caspase-3Amanda K. Frank, E.
Kristina, Heyne, Klaus, Roemer
openaire +2 more sources