Results 11 to 20 of about 16,739,924 (339)
Diagnostics, 2021 Ovarian cancer remains a major diagnostic and therapeutic problem in modern gynecological oncology. For this reason, research which focuses on the search for new diagnostic markers and the assessment of their possible usefulness in clinical practice is ...
Aleksandra Mielczarek-Palacz +2 more
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Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity
Cell Death and Disease, 2021 Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers. Pyroptosis, a newly discovered programmed cell death, was recently reported to be associated with kidney diseases.
Xiujin Shen +4 more
semanticscholar +1 more source
Apoptosis in the absence of caspase 3 [PDF]
Oncogene, 2001 MCF-7 human breast cancer cells do not express caspase 3, thought by some to be a critical component of the apoptosis cascade. Nonetheless, both mock- and bcl-2-transfected MCF-7 cells undergo apoptosis after treatment with a variety of stimuli, including the DNA-cleaving antimitotic agent, neocarzinostatin (NCS).
Ye Liang, Nina F. Schor, Chaohua Yan
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Metalloporphyrins inactivate caspase‐3 and ‐8 [PDF]
The FASEB Journal, 2005 Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in vitro settings.
Alexandra K. Kiemer +9 more
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Roles of apoptosis and autophagy in natural rabies infections
Veterinární Medicína, 2022 The aim of this study was to investigate the activity of apoptosis and autophagy in animals (cows, horses, donkeys, dogs and cats) naturally infected with rabies by using immunohistochemistry, immunofluorescence, and qPCR.
M Ozkaraca +3 more
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Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers
International Journal of Molecular Sciences, 2021 The molecular imaging of apoptosis remains an important method for the diagnosis and monitoring of the progression of certain diseases and the evaluation of the efficacy of anticancer apoptosis-inducing therapies.
Lucas Beroske +4 more
semanticscholar +1 more source
Molecular Dynamics Studies of Caspase-3 [PDF]
Biophysical Journal, 2003 Caspase-3 is a fundamental target for pharmaceutical interventions against a variety of diseases involving disregulated apoptosis. The enzyme is active as a dimer with two symmetry-related active sites, each featuring a Cys-His catalytic dyad and a selectivity loop, which recognizes the characteristic DEVD pattern of the substrate.
Ursula Rothlisberger +2 more
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ACS Chemical Biology, 2021 Caspases are a family of enzymes that regulate biological processes such as inflammation and programmed cell death, through proteolysis. For example, in the intrinsic pathway of apoptosis, cell death signaling involves cytochrome c release from the ...
L. E. Araya +3 more
semanticscholar +1 more source
Tau and Caspase 3 as Targets for Neuroprotection [PDF]
International Journal of Alzheimer's Disease, 2012 The peptide drug candidate NAP (davunetide) has demonstrated protective effects in variousin vivoandin vitromodels of neurodegeneration. NAP was shown to reduce tau hyperphosphorylation as well as to prevent caspase-3 activation and cytochrome-3 release from mitochondria, both characteristic of apoptotic cell death. Recent studies suggest that caspases
Anat Idan-Feldman +2 more
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The calpain, caspase 12, caspase 3 cascade leading to apoptosis is altered in F508del-CFTR expressing cells. [PDF]
PLoS ONE, 2009 In cystic fibrosis (CF), the most frequent mutant variant of the cystic fibrosis transmembrane conductance regulator (CFTR), F508del-CFTR protein, is misfolded and retained in the endoplasmic reticulum (ER). We previously showed that the unfolded protein
Mathieu Kerbiriou +4 more
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