Results 211 to 220 of about 16,586,228 (338)

Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome

Advanced Science, EarlyView.
Pinosylvin blocks LPS and RANKL induced NEK7/NLRP3 interaction, inhibiting NLRP3 inflammasome oligomerization and assembly, reducing IL‐1β maturation and GSDMD cleavage, and improving the inflammatory microenvironment and abnormal osteoclastogenesis. Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and
Wei Zhang, Xiangbing Wu, Wenming Li, Haifeng Zhang, Yijun Wang, Jing Xu, Wenhao Li, Yi Qin, Zebin Wu, Gaoran Ge, Shujun Lv, Lu Mao, Liangliang Wang, Dechun Geng   +13 more
wiley   +1 more source

Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia. [PDF]

Nat Commun
Andoh M, Shinoda N, Taira Y, Araki T, Kasahara Y, Takeuchi H, Miura M, Ikegaya Y, Koyama R.   +8 more
europepmc   +1 more source

Apoptosis of NG108-15 Cells Induced by Buprenorphine Hydrochloride Occurs via the Caspase-3 Pathway.

, 2000
Fumihiko Kugawa, Akemichi Ueno, Masatada Aoki   +2 more
openalex   +2 more sources

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Ammonia induces apoptosis in gastric chief cell cultures by damaging mitochondria and activating caspase-3

, 2000
Hui Wu, Susan J. Hagen
openalex   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Metamizole limits proliferation in chronic myeloid leukemia cells and triggers apoptosis via the bax/bcl-2/caspase-3 cascade. [PDF]

Med Oncol
Maytalman E, Nemutlu Samur D.
europepmc   +1 more source

Expression of Bcl-2 family and caspase-3 activity in human neutrophils by Helicobacter pylori watersoluble surface proteins

, 2000
Joo Sung Kim, Jung Mogg Kim, Hyun Chae Jung, You Sun Kim, Il Ju Choi, In Sung Song, Chung Yong Kim   +6 more
openalex   +1 more source

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Advanced Science, EarlyView.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang   +12 more
wiley   +1 more source

αB-crystallin enhances radioresistance in basal-like breast cancer cells by suppressing caspase-3 activation. [PDF]

Sci Prog
Yuan Y, Zhang X, Xu Y, Ge Y, Wu A.
europepmc   +1 more source