Results 221 to 230 of about 16,739,924 (339)

Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis

Advanced Science, EarlyView.
This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang, Donglan Tang, Chenxi Yang, Chao Lin, Yingyue Yuan, Meiying He, Yiying Chen, Zhuo Mao, Ying Ying, Xiaosong Ma, Xiangchen Kong   +10 more
wiley   +1 more source

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Huangqi Baihe Granules Attenuate Hypobaric Hypoxia-Induced Brain Injury via HIF-1a/p53/Caspase-3 Pathway. [PDF]

Drug Des Devel Ther
Zhang X, Cao W, Pan M, Huo J, Zhang N, Guo J, Huang Y, Liu Y, Gong H, Su Y.   +9 more
europepmc   +1 more source

Proteasome Inhibitors Induce Cytochrome c–Caspase-3-Like Protease-Mediated Apoptosis in Cultured Cortical Neurons [PDF]

, 2000
Jian Hua Qiu, Akio Asai, Shunji Chi, Nobuhito Saito, Hirofumi Hamada, Takaaki Kirino   +5 more
openalex   +1 more source

HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer

Advanced Science, EarlyView.
This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su, Yang Wang, Xifeng Qin, Yaqiong Xiao, Boshu Ouyang, Lina Hu, Lin Kang, Ruizhe Xu, Ce Xu, Zanya Sun, Chenyu Sun, Huishu Guo, Zhiqing Pang, Shun Shen   +13 more
wiley   +1 more source

A Metal-Organic Hybrid Composed of Dual Quenching Cofactors as a Nanoquencher for the Fluorescent Determination of Protease Caspase-3. [PDF]

Biosensors (Basel)
Gao F, Liu L, He C, Chang Y, Wang W.
europepmc   +1 more source

High Glucose–Induced Apoptosis in Human Endothelial Cells Is Mediated by Sequential Activations of c-Jun NH ₂ -Terminal Kinase and Caspase-3

, 2000
Feng Ming Ho, Shing‐Hwa Liu, Yook Chin Chia, Por J. Huang, Shoei Yn Lin‐Shiau   +4 more
openalex   +1 more source

Caspase 3-dependent killing of host cells by the parasite Entamoeba histolytica [PDF]

, 2000
Christopher D. Huston, Eric R. Houpt, Barbara J. Mann, Chang S. Hahn, William A. Petri   +4 more
openalex   +1 more source

The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation

Advanced Science, EarlyView.
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng   +16 more
wiley   +1 more source

Fenbendazole induces pyroptosis in breast cancer cells through HK2/caspase-3/GSDME signaling pathway. [PDF]

Front Pharmacol
Pan T, Jin S, Huang X, Xin X, Xing Q, Yang W, Dong J, Li L.   +7 more
europepmc   +1 more source