Results 311 to 320 of about 16,739,924 (339)

Caspase 3 and 8 deficiency in human neuroblastoma

Cancer Genetics and Cytogenetics, 2003
An altered apoptotic response represents a pivotal feature of cancer and is involved in cancerogenesis and resistance to chemotherapy. So far, however, only a few studies have been devoted to survey caspase content in malignant cell lines and primary tumor specimens. In this report, we investigated the expression of two pivotal caspases, 3 and 8, in 63
IOLASCON A, BORRIELLO, Adriana, GIORDANI L, CUCCIOLLA V, MORETTI A, MONNO F, CRINITI V, MARZULLO A, CRISCUOLO M, DELLA RAGIONE, Fulvio   +9 more
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Survivin does not inhibit caspase-3 activity

Blood, 2000
Conway et al recently reported that alternatively spliced forms of mouse survivin exhibit different antiapoptotic properties.[1][1] This was inferred from inhibition of recombinant caspase-3 catalytic activity using a standard chromogenic assay in the presence of increasing concentrations ...
Dario C. Altieri, Damon Banks, Janet Plescia, Haichao Zhang, Shi-Chung Ng, Jun Chen, Saul H. Rosenberg   +6 more
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Differential regulation of caspase-3 by pharmacological and developmental stimuli as demonstrated using humanised caspase-3 mice

Apoptosis, 2004
Caspase-3 is a potential therapeutic target for a number of degenerative diseases. However the development of specific caspase-3 inhibitors has been hampered by inter-species differences and the high degree of homology shared by different caspases.
J Sharkey, N Logan, G Carlson, A Simon, J-L A Birse-Archbold, Lorraine E. Kerr, Donald W. Nicholson, John S. Kelly, F Scott   +8 more
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Active caspase‐3 is required for osteoclast differentiation

Journal of Cellular Physiology, 2006
AbstractBased on our earlier observation that caspase‐3 is present in osteoclasts that are not undergoing apoptosis, we investigated the role of this protein in the differentiation of primary osteoclasts and RAW264.7 cells (Szymczyk KH, et al., 2005, Caspase‐3 activity is necessary for RANKL‐induced osteoclast differentiation.
Szymczyk, K. H., Freeman, T. A., Adams, Christopher S., Srinivas, V., Steinbeck, M. J.   +4 more
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Expression of Survivin and Caspase-3 in Gastric Cancer

Digestive Diseases and Sciences, 2003
Gastric cancer is one of the most common malignant tumors of the gastrointestinal tract. However, the molecular pathways involved in the regulation of gastric carcinogenesis are not completely elucidated. In the last decade, basic cancer research has been focused on the deregulation of apoptosis as a central event in the process of carcinogenesis ...
J. Kania, K. Marlicz, Stanislaw J. Konturek, P C Konturek, Eckhart G. Hahn   +4 more
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Caspase-3 as a therapeutic target for heart failure

Expert Opinion on Therapeutic Targets, 2013
Heart failure is a condition with significant morbidity and high mortality. It is likely to become unmanageable in the rapidly increasing aging population, due mainly to lack of effective treatment. Apoptosis is one of the major mechanisms causing cardiomyocyte loss in the failing hearts of both human patients and animal models.
Yang, B, Ye, D, Wang, Y
openaire   +5 more sources

FITC–quencher based caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells

Nanoscale, 2013
By employing fluorescence resonance energy transfer (FRET) quenching, we rationally designed two new FITC-quencher based nanoprobes for effectively sensing caspase 3 (Casp3) in vitro and in cells. Our nanoprobes hold promise for assessing the chemotherapeutic effect of cancer treatment.
Gaolin Liang, Anming Tang, Fang Li, Mian Wu, Hua Cui, Weijuan Wang, Qing Yang, Wanglai Hu, Jun Zhou, Bin Mei   +9 more
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Blockade of processing/activation of caspase-3 by hypoxia

Biochemical and Biophysical Research Communications, 2008
Tumor hypoxia, which is caused by the rapid proliferation of tumor cells and aberrant vasculature in tumors, results in inadequate supplies of oxygen and nutrients to tumor cells. Paradoxically, these unfavorable growth conditions benefit tumor cell survival, although the mechanism is poorly understood.
Dai-Wu Seol, Sang Hee Han, Tae-Hyoung Kim, Moonil Kim, Kyoungsook Park   +4 more
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Kinetic comparison of procaspase-3 and caspase-3

Archives of Biochemistry and Biophysics, 2005
Caspases, the key enzymes in apoptosis, are synthesized as proenzymes and converted into active form by proteolytic cleavage. The residues on active site reorganize during the activation process as shown in the comparative studies of crystallographic structures of procaspase-7 and its mature form.
Pratap Karki, Song Yub Shin, Il-Seon Park, Byungyun Cho, Jung-Sup Lee   +4 more
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Flow Cytometric Detection of Activated Caspase-3

2008
Apoptosis (programmed cell death) is an active process that plays a critical role in multiple biologic processes from embryologic development, to lymphocyte development and selection, and homeostasis. The two major mechanisms of cell death are referred to as the intrinsic and extrinsic pathways.
Richard Fox, Martine Aubert
openaire   +3 more sources