Results 321 to 330 of about 476,553 (353)

MK2 Phosphorylates Caspase‐3, Facilitates Nuclear Translocation of Caspase 3, and Regulates Apoptosis

The FASEB Journal, 2022
Background Apoptosis is a necessary and key pathologic feature in the development of acute lung injury (ALI). Previous research has identified MAPK Activated Protein Kinase 2 (MK2) as a potential regulator in the development of apoptosis, by facilitating the nuclear translocation of active caspase‐3, the ...
Othello Lance Del Rosario, Karthik Suresh, Larissa Shimoda, Madhavi Rane, Mahendra Damarla   +4 more
openaire   +1 more source

Novel zebrafish caspase-3 substrates

Biochemical and Biophysical Research Communications, 2007
The zebrafish model has been widely used to investigate numerous signaling pathways in vertebrates, including programmed cell death. Although several zebrafish proteins homologous to mammalian caspases have been identified, our understanding of these zebrafish caspases is still limited.
C Alexander, Valencia, Christian, Bailey, Rihe, Liu   +2 more
openaire   +2 more sources

Survivin does not inhibit caspase-3 activity

Blood, 2000
Conway et al recently reported that alternatively spliced forms of mouse survivin exhibit different antiapoptotic properties.[1][1] This was inferred from inhibition of recombinant caspase-3 catalytic activity using a standard chromogenic assay in the presence of increasing concentrations ...
D P, Banks, J, Plescia, D C, Altieri, J, Chen, S H, Rosenberg, H, Zhang, S C, Ng   +6 more
openaire   +2 more sources

Posttranslational Regulation of Bim by Caspase‐3

Annals of the New York Academy of Sciences, 2007
Abstract:  Bim is a proapoptotic BH3‐domain‐only member of the Bcl‐2 family, and its expression is regulated both transcriptionally and posttranslationally. We developed an in vitro system examining the posttranslational regulation of Bim. Since Bim is a strong mediator of apoptosis, it has been quite difficult to establish cell lines stably ...
Hidetoshi, Wakeyama, Toru, Akiyama, Yuho, Kadono, Masaki, Nakamura, Yasushi, Oshima, Kozo, Nakamura, Sakae, Tanaka   +6 more
openaire   +2 more sources

Caspase-3 Induced Apoptosis in Transgenic Zebrafish

Biotechnology Letters, 2006
Zebrafish is an attractive model organism for studying apoptosis development because of its genetic accessibility. Here we describe the induction of clonally derived apoptosis in transgenic zebrafish expressing mouse caspase-3 (CASP3) under control of the zebrafish beta-actin promoter (betap).
Chiranjib, Chakraborty, Gargi, Saha, Biplab, Sarkar, S, Pal, T K, Chatterjee, A K, Sadhu   +5 more
openaire   +2 more sources

Caspase-3-Responsive, Fluorogenic Bivalent Bottlebrush Polymers

ACS Macro Letters
Controlling the access of proteases to cleavable peptides placed at specific locations within macromolecular architectures represents a powerful strategy for biologically responsive materials design. Here, we report the synthesis of peptide-containing bivalent bottlebrush (co)polymers (BBPs) featuring polyethylene glycol (PEG) and 7-amino-4 ...
Hadiqa Zafar, Bin Liu, Hung V.-T. Nguyen, Jeremiah A. Johnson   +3 more
openaire   +2 more sources

Flow Cytometric Detection of Activated Caspase-3

2008
Apoptosis (programmed cell death) is an active process that plays a critical role in multiple biologic processes from embryologic development, to lymphocyte development and selection, and homeostasis. The two major mechanisms of cell death are referred to as the intrinsic and extrinsic pathways.
Richard, Fox, Martine, Aubert
openaire   +2 more sources

Caspase 3 in breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2003
An inability to undergo apoptosis is widely thought to contribute to both tumorigenesis and tumor progression. One of the key mediators of apoptosis is the thiol protease caspase 3. In this investigation, caspase 3 mRNA and protein expression in breast cancer was examined.Caspase 3 was measured at the mRNA level using reverse transcription-PCR and at ...
Norma, O'Donovan, John, Crown, Helen, Stunell, Arnold D K, Hill, Enda, McDermott, Niall, O'Higgins, Michael J, Duffy   +6 more
openaire   +1 more source

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome

Nature, 2023
Yanjie Hou, Jingjin Ding, Shao Feng
exaly  

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

Cell, 2020
Min Zheng, Rajendra Karki, Peter Vogel
exaly