Results 41 to 50 of about 460,615 (302)

Intracellular zinc depletion induces caspase activation and p21Waf1/Cip1 cleavage in human epithelial cell lines [PDF]

, 2000
To better understand the mechanisms by which zinc deficiency induces epithelial cell death, studies were done of the effects of intracellular zinc depletion induced by the zinc chelator TPEN on apoptosis-related events in human malignant epithelial cell ...
A. Evdokiou, A. Q. Truong‐Tran, Cui L, F. Chai, G. P. Young, Kolenko V, Krajewska M, Mahadevan I, Medina V, P. D. Zalewski, Shankar AH, Solomons NW, Teare JM, Waga S, Zalewski PD, Zalewski PD   +15 more
core   +1 more source

Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism. [PDF]

, 2014
We examined the apoptotic effect of a novel Probiotics Fermentation Technology (PFT) kefir grain product; PFT is a natural mixture composed primarily of Lactobacillus kefiri P-IF, a specific strain of L. kefiri with unique growth characteristics. The aim
Ghoneum, Mamdooh, Gimzewski, James
core   +1 more source

Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis [PDF]

, 2016
Programmed cell death (PCD) is used by plants for development and survival to biotic and abiotic stresses. The role of caspases in PCD is well established in animal cells.
A Canbay, A Danon, A Danon, A Danon, A Darehshouri, A Tsuji, A Zakharov, A Zuppini, B Belenghi, BS Tiwari, C Carter, C Gao, C Gu, C Illy, E A McKenzie, EA Minina, GE Drury, H McLellan, H McLellan, J Jiao, J Kacprzyk, J Rozman-Pungercar, J Rozman-Pungercar, J-J Han, L Bonneau, L Bonneau, L Mach, L Tsiatsiani, M Kim, M Niemer, ME Guicciardi, N Hatsugai, N Watanabe, NS Coll, NV Chichkova, O del Pozo, P Boya, P Gallois, R He, R Iglesias-Fernández, RA Vacca, S Chen, T Cirman, U Repnik, V Rotari, VI Rotari, VI Rotari, WG van Doorn, Y Ge, Y-M Cai, Z-T Yang   +50 more
core   +10 more sources

Apoptosis in prostate carcinoma tissue: The role of caspase-3, caspase-1, and alkaline DNase activity [PDF]

Journal of Medical Biochemistry
Background: Prostate glandular tissue maintains a delicate balance between cellular proliferation and programmed cell death (apoptosis), ensuring the preservation of normal glandular architecture in healthy individuals.
Veljkovic Andrej, Hadzi-Djokic Jovan, Kocic Gordana, Li Xiaobo, Roumeliotis Stefanos, Sokolović Dušan, Klisic Aleksandra   +6 more
doaj   +1 more source

Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]

, 2009
The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele, De Martino, Luisa, Di Stefano, Carla, Fiorito, Filomena, Indelicato, Manuela, Marfe, Gabriella, Pucci, Bruna, Russo, Matteo A., Tafani, Marco   +8 more
core   +1 more source

Platelet microparticles contain active caspase 3

Platelets, 2008
During storage, platelets undergo processes resembling apoptosis, including microparticle release, aminophospholipid exposure, and procaspase 3 processing. Recently, we showed that microparticles from endothelial cells contain caspase 3, one of the executioner enzymes of apoptosis.
Böing, Anita N., Hau, Chi M., Sturk, Auguste, Nieuwland, Rienk   +3 more
openaire   +2 more sources

Caspase-3 Promotes Genetic Instability and Carcinogenesis [PDF]

Molecular Cell, 2015
Apoptosis is typically considered an anti-oncogenic process since caspase activation can promote the elimination of genetically unstable or damaged cells. We report that a central effector of apoptosis, caspase-3, facilitates rather than suppresses chemical- and radiation-induced genetic instability and carcinogenesis.
Xinjian, Liu, Yujun, He, Fang, Li, Qian, Huang, Takamitsu A, Kato, Russell P, Hall, Chuan-Yuan, Li   +6 more
openaire   +2 more sources

Does Sinapic Acid Provide Neuroprotection Against Cisplatin-Induced Toxicity in HT-22 Cells

Van Tıp Dergisi, 2023
INTRODUCTION: This study aimed to explain the beneficial effects and possible protective mechanisms of Sinapic acid(SA) against cisplatin-induced oxido-inflammatory damage in HT-22 rat hippocampal cells by biochemical and molecular methods.
Betül Çiçek, Sıdıka Genç
doaj   +1 more source

Ekspresi Caspase-3 Pada Sel Epitel Rongga Mulut (Kb Cell Line) Setelah Paparan Ekstrak Kopi [PDF]

, 2014
Kopi adalah minuman yang biasa dikonsumsi oleh masyarakat sehari-hari. Telah diketahui bahwa kopi mengandung kafein seperti yang terdapat juga pada teh dan coklat. Kandungan terbanyak kafein terdapat pada kopi.
Hutomo, S. (Suryani), Maheswara, D. C. (Devi), Phym, A. R. (Agustinus), Suryanto, Y. I. (Yanti), Susilowati, H. (Heni)   +4 more
core   +4 more sources

Overexpression of caspase-3 in hepatocellular carcinomas [PDF]

Modern Pathology, 2004
Caspase-3 is a downstream effector cysteine protease in the apoptotic pathway. It is ubiquitously expressed in normal human tissues including the liver. Overexpression and loss of expression of caspase-3 has been reported in diverse human malignancies. However, expression of caspase-3 in hepatocellular carcinoma (HCC) has not been studied.
Rajendra, Persad, Chen, Liu, Tsung-Teh, Wu, Patrick S, Houlihan, Stanley R, Hamilton, Anna M, Diehl, Asif, Rashid   +6 more
openaire   +2 more sources