Results 41 to 50 of about 16,586,228 (338)

An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells

Biotechnology Reports, 2015
The effects of reactive oxygen species on cells have attracted great attention from both physiological and pathological aspects. Superoxide (O2−) is the primary reactive oxygen species formed in animals.
Minoru Tamura, Sachio Kunihiro, Yuki Hamashima, Yuki Yoshioka, Shigenobu Tone, Kenji Kameda   +5 more
doaj   +1 more source

Caspase-3

Definitions, 2020
Caspase-3 (277 aa, ~31 kDa) is encoded by the human CASP3 gene. This protein is involved in the mediation of proteolysis and the activation of apoptosis.

semanticscholar   +1 more source

Expression of caspase-3, caspase-9, GDF-9 and IGF-1 genes in ovine oocytes cultured with optimum and elevated doses of Amphiregulin, Neuregulin-1 and Tumour necrosis factor-α in-vitro

Indian Journal of Animal Sciences, 2022
The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY, NANDI SUMANTA, GIRISH KUMAR VENKATESH   +2 more
doaj   +1 more source

TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis

Cell Death Discovery, 2023
Sarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated with the development of sarcopenia that is characterized by reduction of muscle fiber size and number ...
Jingying Wu, Siming Lin, Weixiao Chen, Guili Lian, Weibin Wu, Ai Chen, Mohammad Ismail Hajary Sagor, Li Luo, Huajun Wang, Liangdi Xie   +9 more
doaj   +1 more source

Allosteric modulation of caspase 3 through mutagenesis [PDF]

Bioscience Reports, 2012
A mutation in the allosteric site of the caspase 3 dimer interface of Val266 to histidine abolishes activity of the enzyme, and models predict that the mutation mimics the action of small molecule allosteric inhibitors by preventing formation of the active site. Mutations were coupled to His266 at two sites in the interface, E124A and Y197C. We present
A. Clay Clark, Paul Swartz, Carla Mattos, Jad Walters, J.L. Schipper   +4 more
openaire   +2 more sources

Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders

Physiological Reports, 2019
Excessive cellular accumulation or exposure to lipids such as long‐chain acylcarnitines (LCACs), ceramides, and others is implicated in cell stress and inflammation.
Colin S. McCoin, Melanie B. Gillingham, Trina A. Knotts, Jerry Vockley, Kikumi D. Ono‐Moore, Michael L. Blackburn, Jennifer E. Norman, Sean H. Adams   +7 more
doaj   +1 more source

The Role of Caspases in Melanoma Pathogenesis

Current Issues in Molecular Biology
Melanoma (malignant melanoma, MM) is an aggressive malignant skin cancer with an increasing incidence rate. The complete pathogenesis of MM in not clear.
Agnieszka Szmurło, Klaudia Dopytalska, Michał Szczerba, Elżbieta Szymańska, Alicja Petniak, Marcin Kocki, Janusz Kocki, Irena Walecka   +7 more
doaj   +1 more source

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

Science Advances, 2019
Caspase-3 and -7 are redundantly required to amplify the extrinsic and intrinsic apoptotic cascade in human leukemia. Apoptosis is a complex multi-step process driven by caspase-dependent proteolytic cleavage cascades. Dysregulation of apoptosis promotes
S. McComb, Pik Ki Chan, A. Guinot, Holmfridur Hartmannsdottir, S. Jenni, M. P. Dobay, J. Bourquin, B. Bornhauser   +7 more
semanticscholar   +1 more source

Does Sinapic Acid Provide Neuroprotection Against Cisplatin-Induced Toxicity in HT-22 Cells

Van Tıp Dergisi, 2023
INTRODUCTION: This study aimed to explain the beneficial effects and possible protective mechanisms of Sinapic acid(SA) against cisplatin-induced oxido-inflammatory damage in HT-22 rat hippocampal cells by biochemical and molecular methods.
Betül Çiçek, Sıdıka Genç
doaj   +1 more source

Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways

Drug Design, Development and Therapy, 2019
Background: Liver fibrosis occurs due to chronic liver disease due to multiple pathophysiological causes. The main causes for this condition are chronic alcohol abuse, nonalcoholic steatohepatitis, and infection due to hepatitis C virus. Currently, there
Rong Wang, Fuxing Song, Shengnan Li, Bin Wu, Yanqiu Gu, Yongfang Yuan   +5 more
semanticscholar   +1 more source