Results 91 to 100 of about 11,510,202 (303)

Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity

Frontiers in Immunology, 2021
Non-canonical inflammasome activation by mouse caspase-11 (or human CASPASE-4/5) is crucial for the clearance of certain gram-negative bacterial infections, but can lead to severe inflammatory damage.
Debabrata Chowdhury, Jason C. Gardner, Abhijit Satpati, Suba Nookala, Santhosh Mukundan, Aleksey Porollo, Aleksey Porollo, Aleksey Porollo, Julio A. Landero Figueroa, Kavitha Subramanian Vignesh   +9 more
doaj   +1 more source

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation [PDF]

, 2017
Gram-negative bacteria are associated with a wide spectrum of infectious diseases in humans. Inflammasomes are cytosolic protein complexes that are assembled when the cell encounters pathogens or other harmful agents.
Angus, Baker, Chakrabarti, Chen, Cypryk, Cypryk, Hagar, He, Hikita, Horiuchi, Hotamisligil, Kayagaki, Kaye, Lampinen, Lee, Lemaitre, Lietzén, Medzhitov, Meissner, Mohr, Mosoian, O'Connell, Ohman, Pirhonen, Poltorak, Pruenster, Qiu, Rabouille, Raposo, Rayamajhi, Romani, Saftig, Schroder, Shi, Storek, Szklarczyk, Vizcaíno, Vogl, Välimäki, Välimäki, Yang, Zanoni, Zhang, Zhu, Öhman   +44 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

The cytoskeleton in cell-autonomous immunity: structural determinants of host defence

, 2015
Host cells use antimicrobial proteins, pathogen-restrictive compartmentalization and cell death in their defence against intracellular pathogens. Recent work has revealed that four components of the cytoskeleton — actin, microtubules, intermediate ...
A Ablasser, A Akhter, A Desai, A Fukazawa, A Stolz, AB Jaffe, AF Frade, AJ Thrasher, AL Waite, AM Keestra, AP West, AR Shenoy, Avinash R. Shenoy, B Levine, B-H Kim, BB Mishra, BT Kile, C Stevens, C Watts, CM Haglund, CS Weirich, D Chen, D Ghosal, D Parker, D Sancho, DC Rubinsztein, DJ Philpott, DL Clemens, DM Underhill, E Bi, E Caron, EL Benanti, F Caudron, F Martinon, F Randow, F Randow, F Rees, G Bonizzi, G dos Santos, G Kuhlenbaumer, G Tran Van Nhieu, H Bielig, H Herrmann, H Sridharan, H Xu, HB Yu, HS Goodridge, I Monastyrska, IM Dambuza, J Eitel, J Huang, J Jin, J Li, J Li, J Pizarro-Cerdá, J Saarikangas, J Shi, J von Moltke, J-G Zhang, JA Hagar, JA Swanson, JC Kagan, JCH Tam, JD MacMicking, JJ Bravo-Cordero, JL Dangl, JP Solomon, JR Terman, JS Hyams, JSC Arthur, JW Jones, K Aktories, K Aktories, K Dobbs, K Gotoh, KL Angus, L Blanchoin, L Kong, L Le Bourhis, LA Cameron, LA Knodler, LJF Jones, M Kokes, M Lamkanfi, M Ogawa, M Ogawa, M Pasparakis, M Rosas, M Sasai, M Yoneyama, MA Al-Zeer, MA Gavrilin, MA Gavrilin, MA Gavrilin, MA Sanjuan, MB Torchinsky, MD Welch, MJG Eldridge, ML Kim, MT Cabeen, N Ausmees, N Carayol, N Kayagaki, N Kayagaki, N Mizushima, N Ostler, N Schroeder, N Subramanian, NE Harwood, NT Snider, P Cossart, P Hanc, P Wild, P Xia, PS Manzanillo, R Goldbach-Mansky, R Mackeh, R Muñoz-Planillo, RC Wang, RE Vance, S Ahrens, S Asrat, S Iborra, S Legrand-Poels, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Park, S Savic, S Zelenay, SA Schattgen, SCO Reed, Serge Mostowy, SL Sandiford, SM Man, T Fernandes-Alnemri, T Kawai, T Misawa, T Strowig, T Tamura, TA Kufer, TD Pollard, TLM Thurston, U Golebiewska, V Deretic, VAK Rathinam, VAK Rathinam, W-D Hardt, WA McEwan, WM Schneider, X Cai, Y Aachoui, Y Aachoui, Y Kumar, Y Ma, Y Song, Y Tanaka-Takiguchi, Y Yoshikawa, Y Zhao, Y-W Huang, YT Zheng   +165 more
core   +1 more source

Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis. [PDF]

, 2017
Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis, prognosis, and treatment.
Dubois, Laura G, Gilchrist, James J, Ginsburg, Geoffrey S, Hill, Adrian VS, Jaslow, Sarah L, Kenyan Bacteraemia Study Group, Ko, Dennis C, Ko, Emily R, Langley, Raymond J, Moseley, M Arthur, Mturi, Neema, Mwarumba, Salim, Njuguna, Patricia, Pirinen, Matti, Pittman, Kelly J, Rautanen, Anna, Rouse, D Clayburn, Salinas, Raul E, Scott, J Anthony G, Thompson, J Will, Tsalik, Ephraim L, Wang, Liuyang, Wellcome Trust Case Control Consortium 2, Williams, Thomas N, Woods, Christopher W   +24 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Role of the Inflammasome in Nonmyeloid Cells [PDF]

, 2018
Inflammasomes are cytosolic multiprotein complexes that can proteolytically activate caspase-1. Activated caspase-1 is needed for the maturation and secretion of interleukin (IL)-1β and IL-18. In the past decade, there has been tremendous progress in our
Drexler, Stefan, Tschopp, Jürg, Yazdi, Amir   +2 more
core  

Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database. [PDF]

, 2012
BACKGROUND: Huntington's disease (HD) is a fatal progressive neurodegenerative disorder caused by the expansion of the polyglutamine repeat region in the huntingtin gene.
A Caricasole, A Hodges, A Hughes, A Kuhn, A Pal, A Yamamoto, AD Strand, AL Orr, AV Panov, B Ravikumar, BL Apostol, C Giampa, C Landles, C Song, C Zuccato, CM Batista, D Lim, DA Sahlender, DC Lagace, DC Rubinsztein, E Genin, E Okun, E Perez-Navarro, EA Nollen, EA Thomas, EJ Bennett, EM Bublil, FM Ribeiro, FO Walker, GD Fischbach, H Nishitoh, HJ Rideout, I Munoz-Sanjuan, J Busser, J Gayan, J Kassubek, J Schiefer, JC Lievens, JC Vis, JC Vis, JD Godin, JF Gusella, JJ Lucas, JL Li, JL Li, JM Andresen, JM Gil, JM Lee, JP Caviston, JP Vonsattel, JR Gatchel, JS Steffan, JT Coyle, K Herrup, KL Richard, KT Lin, L Arning, L Mei, LA Farrer, LA Passani, M DiFiglia, M DiFiglia, M DiFiglia, M Politis, M Song, MA Curtis, Matthias E Futschik, MD Kaytor, Miguel A Hernández-Prieto, MT Lorincz, N Majdzadeh, NF Bence, NS Wexler, P Harjes, P Weydt, PW Faber, Ravi Kiran Reddy Kalathur, RC Gentleman, RG Snell, S Frank, S Gines, S Holbert, S Luo, S Tydlacka, S Waelter, S Zhang, SB Shelton, SE Andrew, SE Andrew, T Wada, TS Tang, TS Tang, Y Hochberg, Y Sun, Y Yarden, Y Zhang, YF Liu, YJ Jiang, YS Choo, Z Berger   +99 more
core   +4 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source