Results 101 to 110 of about 8,801,929 (295)

Caspase-8 RNA half-life and CpG positions on its promoter proximal region.

, 2022
(A) Quantification of caspase-8 mRNA to check its half-life post transcriptional block (using Actinomycin-D) (n = 3). (B) In situ hybridization with anti-sense and sense probe of caspase-8 RNA (in vitro) [scale = 10 μm].
Akshay Hegde (13813404), Rakesh Dey (13813401), Ashim P. Deb (13813410), Shravanti Rampalli (13813413), Tanay Bhatt (13813398), Colin Jamora (70905), Ajai J. Pulianmackal (11822651), Alhad Ashok Ketkar (13813407)   +7 more
core   +1 more source

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge model for Human Skin and its Diseases

Advanced Healthcare Materials, EarlyView.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Thomas Kündig, Hans‐Dietmar Beer   +4 more
wiley   +1 more source

A comprehensive characterization of the caspase gene family in insects from the order Lepidoptera

BMC Genomics, 2011
Background The cell suicide pathway of apoptosis is a necessary event in the life of multicellular organisms. It is involved in many biological processes ranging from development to the immune response. Evolutionarily conserved proteases, called caspases,
Vogel Heiko, Pauchet Yannick, Courtiade Juliette, Heckel David G   +3 more
doaj   +1 more source

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects

, 2008
Background: The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors.
Caoimhin G Concannon, Anguissola, Sergio, Barbara Köhler, Jochen H M Prehn, Markus Rehm (7899308), Kögel, Donat, Barbara Köhler (60110), Caoimhín G. Concannon (7953038), Donat Kögel, Sergio Anguissola, Prehn, Jochen H. M., Donat Kögel (60113), Köhler, Barbara, Rehm, Markus, Sergio Anguissola (60111), Jochen Prehn (7895672), Concannon, Caoimhin G., Markus Rehm   +17 more
core   +1 more source

TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells [PDF]

, 2016
The intracellular cysteine protease caspase-1 is critically involved in obesity-induced inflammation in adipose tissue. A substantial body of evidence from immune cells, such as macrophages, has shown that caspase-1 activation depends largely on a ...
Furuoka, Mana, Daichi Sadatomi, Mamiya, Sayaka, Tanimura, Susumu, Tomo Yonezawa, Takeda, Kohsuke, Susumu Tanimura, Mana Furuoka, Sadatomi, Daichi, Sayaka Mamiya, Kei‐Ichi Ozaki, Ozaki, Kei-Ichi, Kohsuke Takeda, Yonezawa, Tomo   +13 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Magnesium oxide nanoparticles: A novel shield against CCl₄- induced hepatic damage via caspase-3 and TNF-α in rats

Open Veterinary Journal
Background: Carbon tetrachloride (CCl₄) is a widely used hepatotoxin that induces liver injury through apoptosis and inflammation. Magnesium oxide (MgO) nanoparticles have shown potential hepatoprotective effects, which may depend on synthesis ...
Harseen M. Rahim, Nadia A. Salih, Bruska Azhdar   +2 more
doaj   +1 more source

Data in the activities of caspases and the levels of reactive oxygen species and cytochrome c in the •OH-induced fish erythrocytes treated with alanine, citrulline, proline and their combination

Data in Brief, 2016
The present study explored the effects of alanine (Ala), citrulline (Cit), proline (Pro) and their combination (Ala10Pro4Cit1) on the activities of caspases and levels of reactive oxygen species (ROS) and cytochrome c in hydroxyl radicals (•OH)-induced ...
Huatao Li, Weidan Jiang, Yang Liu, Jun Jiang, Yongan Zhang, Pei Wu, Juan Zhao, Xudong Duan, Xiaoqiu Zhou, Lin Feng   +9 more
doaj   +1 more source

Caspase-9 cleavage: do you need it

, 2007
Caspase-9 which is activated by association with the Apaf-1 apoptosome complex cleaves and activates the downstream effector caspases-3 and -7, thereby executing the caspase-cascade and cell death programme.
Davina Twiddy (7582331), Kelvin Cain (1784650)   +1 more
core  

Caspase-1 inhibition by YVAD generates tregs pivoting IL-17 to IL-22 response in β-glucan induced airway inflammation

, 2022
During Aspergillus fumigatus mediated lung inflammation, NLRP3 inflammasome is rapidly activated that aggravates IL-1β production contributing to lung inflammation.
Parameswar Dalai (12159242), Divyesh Patel (5476793), Shivani Yadav (12159236), Dipeeka Mandaliya (12159233), Hima Vora (12159245), Omkar Naik (12159239), Dhruvi Shah (4951405), Naveen Challagundla (12159230), Reena Agrawal-Rajput (4951399)   +8 more
core   +1 more source