Results 121 to 130 of about 8,801,929 (295)

Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor

, 2011
Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
Tianhui Hu, Rupesh Chaturvedi, Yan Shi, Hamwei Cao, Fang Yan, Lihong Wang, Liping Liu, Keith Wilson, D. Brent Polk   +8 more
core  

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Caspase-3 activity increases following QLT-0276 treatment in paired females.

, 2017
Result of the caspase-3 activity assay showing that compared to a DMSO-treated control (left) the activity of caspase-3 of S. mansoni increased significantly (p = 0.01) in paired females treated with 100 μM QLT-0276 (right) as determined ...
Steffen Hahnel (437327), Christoph G. Grevelding (107094), Marion Morel (154333), Colette Dissous (107088), Katia Cailliau (107091), Verena Gelmedin (342441)   +5 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release.

PLoS ONE, 2019
Processing of pro-interleukin (IL)-1β and IL-18 is regulated by multiprotein complexes, known as inflammasomes. Inflammasome activation results in generation of bioactive IL-1β and IL-18, which can exert potent pro-inflammatory effects.
Thi Anh Thu Tran, Hendrika W Grievink, Katarzyna Lipinska, Cornelis Kluft, Jacobus Burggraaf, Matthijs Moerland, Dimitar Tasev, Karen E Malone   +7 more
doaj   +1 more source

Caspase-3 immunohistochemical staining of kidney section of rats.

, 2016
Kidney sections of normal rats (a) showing no immune-reactive cells, PDC-treated group (b) showing Diffuse intensely stained immune-reactive cells, PDC-Lf (200 mg/kg) treated rats (c) showing few number of faintly stained immune-reactive cells, and PDC ...
Azza Hassan (678637), Rehab Hegazy (3176562), Dina Mansour (3176559), Abeer Salama (3176565)   +3 more
core   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Caspase-independent role of Apaf1 in T cell activation.

, 2018
LN cells from immunized Apaf1f/f-OTII or Lck-Cre-Apaf1f/f -OTII mice were stimulated with indicated doses of OVA or anti-CD3ε antibody in the presence or absence of z-VAD-fmk (z-VAD) for 48 hours.
Yasunobu Miyake (522605), Yoichiro Iwakura (23402), Hiromitsu Hara (161948), Hiroki Yoshida (85600), Honglian Tong (2218588), Fumika Mi-ichi (347083)   +5 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Ekspresi Caspase-3 pada Kanker Payudara Tikus Setelah Pemberian Antikanker Brusein-A

Global Medical & Health Communication, 2017
Abstrak Brusein-A diduga menyebabkan apoptosis. Salah satu protein yang berperan dalam proses apoptosis adalah caspase-3. Penelitian ini bertujuan mengetahui aktivitas antikanker brusein-A terhadap ekspresi caspase-3 pada kanker payudara.
Muhartono Muhartono, Subeki Subeki
doaj