Results 91 to 100 of about 8,801,929 (295)

Incorporation of Selenium into Sol–Gel‐Derived Bioactive Glass: Influence on Glass Structure, Bioactivity, and its Selective Cytotoxicity

Advanced Engineering Materials, EarlyView.
Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni, Thalita Marcolan Valverde, Talita Martins, Guilherme Mattos Jardim Costa, Alfredo Miranda de Goes, Marcello Rosa Dumont, Eduardo Henrique Martins Nunes, Marivalda de Magalhães Pereira   +7 more
wiley   +1 more source

Neuroprotective Effects of Methyl 3,4-dihydroxybenzoate Against H2O2-Induced Apoptosis in RGC-5 Cells

Journal of Pharmacological Sciences, 2014
.: In the present study, we investigated the protective effect of methyl 3,4-dihydroxybenzoate (MDHB) against H2O2-induced apoptosis in RGC-5 cells. The RGC-5 cells were cultured in plates for 24 h, which were then pretreated with dimethyl sulfoxide ...
Xing Zhou, Chao-Fen Su, Zheng Zhang, Chen-Yu Wang, Jin-Qi Luo, Xiao-Wen Zhou, Liang Cai, Li Yan, Wei Zhang, Huan-Min Luo   +9 more
doaj   +1 more source

Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-Induced Apoptosis in Human Periodontal Ligament Cells

, 2016
BackgroundHuman periodontal ligament (PDL) cells underwent apoptosis after mechanical stretch loading. However, the exact signalling pathway remains unknown.
Chun Xu (286394), Fuqiang Zhang (404974), Dan Zhao (285025), Jiabao Zhuang (3394868), Yaqin Wu (275577)   +4 more
core   +1 more source

Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Advanced Functional Materials, EarlyView.
We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang, Yi Xie, Sihan Yu, Thomas Wynn, Xiangping Liu, Ju‐Chun Hsieh, Jinmo Jeong, Weilong He, Brinkley Artman, Anakaren Romero Lozano, Xi Shi, Arjun Sangani, Lief E Fenno, Samantha Santacruz, Banglin Chen, Huiliang Wang   +18 more
wiley   +1 more source

Heat shock and HSP70 regulate 5-FU-mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice

Journal for ImmunoTherapy of Cancer, 2020
Background We have previously shown that 5-fluorouracil (5-FU) selectively kills myeloid-derived suppressor cells (MDSCs) and activates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome.
Francois Ghiringhelli, Emeric Limagne, Thomas Pilot, Aurélie Fratti, Chloé Thinselin, Anaïs Perrichet, Lucie Demontoux, Alis Ilie, Mané Ndiaye, Elise Jacquin, Carmen Garrido, Fanny Chalmin, Cédric Rébé   +12 more
doaj   +1 more source

Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures

, 2010
Background The xylem vascular system is composed of fused dead, hollow cells called tracheary elements (TEs) that originate through trans-differentiation of root and shoot cambium cells. TEs undergo autolysis as they differentiate and mature.
Elena T Iakimova, Ernst J Woltering, Qian Tian, Twumasi, P., Schel Jan HN, Emons, A.M.C., Wim van Ieperen, Olaf van Kooten, van Ieperen Wim, van Kooten, O., van Ieperen, W., Iakimova, E.T., van Kooten Olaf, Qian, T., Emons Anne, Schel, J.H.N., Peter Twumasi, Tian Qian, Iakimova Elena T, Woltering, E.J., Anne Emons, Kooten, O., van, Ieperen, W., van, Anne MieC Emons, Twumasi Peter, Woltering Ernst J, Jan HN Schel   +26 more
core   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

suresh-lab/caspase-3 v1

, 2019
A non-apoptotic protective role for Caspase-3 ...
Suresh Lab
core   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Cleavage of pro-caspase-1 into caspase-1 by HMPV.

, 2019
THP-1 cells were differenciated into macrophages using PMA (100 ng/ml) before treatment with 10 μM of MCC950 or DMSO (control) and then infected or not with HMPV or HMPV ΔSH at a MOI of 0.001.
Vuong B. Lê (393003), Marie-Ève Hamelin (5649751), Guy Boivin (12392), Marie-Hélène Cavanagh (710963), Andres Pizzorno (6570038), Manuel Rosa-Calatrava (209542), Julia Dubois (710964), Christian Couture (116443), Olus Uyar (6570035)   +8 more
core   +1 more source