Results 131 to 140 of about 11,510,202 (303)
MSH3 protein expression and nodal status in MLH1-deficient colorectal cancers. [PDF]
, 2012 View the MathML source: Colorectal tumors manifesting high-frequency microsatellite instability (MSI-H) develop genetically as a consequence of mutations in genes harboring repetitive DNA sequences.
Bianchi, P +10 more
core +1 more source
Journal of HepatologyPublished by Elsevier Science, Amsterdam [u.a.]
Michael Rooney +13 more
openaire +3 more sources
In vitro and in vivo anti-cancer activity of silymarin on oral cancer
Tumor Biology, 2018 Silymarin, a standardized extract from milk thistle fruits has been found to exhibit anti-cancer effects against various cancers. Here, we explored the anti-cancer activity of silymarin and its molecular target in human oral cancer in vitro and in vivo ...
Dong-Hoon Won +10 more
doaj +1 more source
Modulation of inflammation in transgenic models of Alzheimer's disease [PDF]
, 2014 Over the past decade the process of inflammation has been a focus of increasing interest in the Alzheimer's disease (AD) field, not only for its potential role in neuronal degeneration but also as a promising therapeutic target.
Birch, AM, Katsouri, L, Sastre, M
core +2 more sources
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Toxicology Reports5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent, but its hepatotoxic potential poses clinical challenges, as it induces oxidative stress, inflammation, and apoptosis in liver tissue.
Ruaa Adnan Mohammed, Nada N. Al-Shawi
doaj +1 more source
Apoptosis: molecular mechanisms and pathogenicity [PDF]
Apoptosis triggered by exogenous and endogenous stimuli such as ultraviolet radiation, oxidative stress, and genotoxic chemicals is a crucial phenomenon within biological systems.
Rastogi, Rajesh P. +2 more
core +1 more source
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. [PDF]
, 2017 Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis.
Broz, P. +16 more
core +2 more sources
Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly
EMBO Journal, 2019 Pyroptosis is a form of lytic inflammatory cell death driven by inflammatory caspase‐1, caspase‐4, caspase‐5 and caspase‐11. These caspases cleave and activate the pore‐forming protein gasdermin D (GSDMD) to induce membrane damage. By contrast, apoptosis
Kaiwen W. Chen +7 more
semanticscholar +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source