Results 261 to 270 of about 8,801,929 (295)

Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1

Biochemical Journal, 2001
Max is the central component of the Myc/Max/Mad network of transcription factors that regulate growth, differentiation and apoptosis. Whereas the Myc and Mad genes and proteins are highly regulated, Max expression is constitutive and no post-translational regulation is known. We have found that Max is targeted during Fas-induced apoptosis. Max is first
A, Krippner-Heidenreich, R V, Talanian, R, Sekul, R, Kraft, H, Thole, H, Ottleben, B, Lüscher   +6 more
openaire   +2 more sources

Abstract 5667: Ferroptosis necessitates caspase 5 dependent GSDME cleavage in ovarian cancer.

Cancer Research
Abstract Ferroptosis, an intracellular iron-catalyzed form of programmed cell death (PCD) driven by lethal lipid reactive oxygen species (ROS)–induced membrane damage, is mechanistically uncharacterized in its execution process as a newly discovered PCD pathway.
Mahmuda Akter, Lei Sun, Cheng Chi, Shuang Huang   +3 more
openaire   +1 more source

Indication of participation of caspase-2 and caspase-5 in mechanisms of human cervical malignancy.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2011
When apoptosis is disrupted, the transformed cells can survive, proliferate, and evolve into a malignancy. The strictly conserved caspase genes and the reliable experimental data clearly show that some caspases play a crucial role in apoptosis even if some of them have no apoptotic activity and others exhibit both apoptotic and nonapoptotic properties.
Evaggelos, Babas, Maria T, Ekonomopoulou, Irine, Karapidaki, Anestakis, Doxakis, George, Betsas, Zafiroula, Iakovidou-Kritsi   +5 more
openaire   +1 more source

AB0112 Caspase-5 inhibitor suppresses pro-inflammatory gene expressions in fibroblast like synoviocytes from patients with rheumatoid arthritis

Annals of the Rheumatic Diseases, 2013
Background Caspases form an evolutionarily conserved family of cytosolic, aspartate-specific, cysteine proteases. Beyond its role in apoptosis, certain caspases (caspase-1, -4, -5, -11 and -12) exert non-apoptotic functions, including cytokine maturation during innate immunity, cell differentiation, proliferation, and NF-κB activation.
Y.-J. Kwon, T.-Y. Kim, S.-W. Lee, Y.-B. Park, S.-K. Lee, M.-C. Park   +5 more
openaire   +1 more source

TGF-βRIl, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder

Pathology, 2007
The aim of this study was to determine the potential synchronous contribution of alterations in TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 genes to the development and clinical outcome of bladder cancer, in relation to p53 mutations, microsatellite status and hMLH1/hMSH2 expression.Molecular biology techniques as well as immunohistochemistry ...
Angelica A, Saetta, Penelope, Korkolopoulou, Maria, Karlou, Georgia, Levidou, Athina, Goudopoulou, Irene, Thymara, Angeliki, Stamatelli, Michalis, Tzivras, Nikolaos V, Michalopoulos, Euphemia, Thomas-Tsagli, Efstratios, Patsouris   +10 more
openaire   +2 more sources

Microsatellite mutations of transforming growth factor-β receptor type II and caspase-5 occur in human precursor T-cell lymphoblastic lymphomas/leukemias in vivo but are not associated with hMSH2 or hMLH1 promoter methylation

Leukemia Research, 2003
In solid cancers, defective DNA mismatch repair (MMR) is most commonly caused by hMSH2 or hMLH1 mutations, or epigenetic silencing of hMLH1 by promoter hypermethylation, and results in the acquisition of characteristic frameshift microsatellite mutations of mononucleotide repeats located within the coding regions of defined target genes.
Stuart, Scott, Tomofumi, Kimura, Ryo, Ichinohasama, Susan, Bergen, Anthony, Magliocco, Cara, Reimer, Annette, Kerviche, David, Sheridan, John F, DeCoteau   +8 more
openaire   +2 more sources

Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.

Cancer research, 1999
The majority of tumors from hereditary nonpolyposis colorectal cancer families and a subset of unselected gastrointestinal and endometrial tumors exhibit a microsatellite mutator phenotype (MMP) that leads to the accumulation of hundreds of thousands of clonal mutations in simple repeat sequences.
S, Schwartz, H, Yamamoto, M, Navarro, M, Maestro, J, Reventós, M, Perucho   +5 more
openaire   +1 more source

Caspase-4 and Caspase-5

2013
Junjun Gao, James A. Wells
openaire   +1 more source

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

Cell, 2020
Min Zheng, Rajendra Karki
exaly  

Caspase-5

2020
openaire   +1 more source