Results 251 to 260 of about 8,801,929 (295)

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5

European Journal of Immunology, 2015
Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase‐4 and caspase‐5. When activated, these trigger pyroptotic cell death and caspase‐1‐dependent IL‐1β production; however the mechanism underlying this process is not yet confirmed.
Paul J Baker, Dave Boucher, Damien Bierschenk   +2 more
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Somatic mutation of the Caspase-5 gene in human lung cancer

International Journal of Molecular Medicine, 2003
Using cDNA array-based gene expression profiling, we previously found reduced expression of the Caspase-5 gene in highly metastatic subpopulations of a lung cancer cell line. The Caspase-5 gene contained poly(A) repeats in its coding region, an area that has been reported to be mutated in both endometrial and gastrointestinal tumors displaying evidence
Y, Hosomi, A, Gemma, Y, Hosoya, M, Nara, T, Okano, K, Takenaka, A, Yoshimura, K, Koizumi, K, Shimizu, S, Kudoh   +9 more
openaire   +2 more sources

Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants

Biochemical and Biophysical Research Communications, 2006
Caspase-5 is a caspase-1-like protease with pro-apoptotic and pro-inflammatory activities. Here we have identified a novel exon at the 5'-end of the human caspase-5 gene. This novel exon was present in six alternatively spliced caspase-5 mRNA variants expressed in human peripheral blood mononuclear cells (PBMC) and encoded the previously unknown amino ...
Leopold, Eckhart, Christian, Kittel, Sonja, Gawlas, Florian, Gruber, Michael, Mildner, Bernd, Jilma, Erwin, Tschachler   +6 more
openaire   +2 more sources

The association between caspase-5 gene polymorphisms and rheumatoid arthritis in a Chinese population

Gene, 2018
Genetic factors are widely recognized to have a substantial effect on the susceptibility to rheumatoid arthritis (RA). We examined the contribution of caspase-5 (CASP5) gene polymorphisms to RA risk in a Chinese population. We conducted a case-control study involving 500 RA patients and 500 controls and performed co-expression analysis to identify ...
Huan, Rui, Ting, Yan, Zhiyong, Hu, Ruiping, Liu, Liqun, Wang   +4 more
openaire   +2 more sources

Association of angiopoietin-1, angiopoietin-2 and caspase-5 polymorphisms with psoriasis vulgaris

Clinical and Experimental Dermatology, 2015
Psoriasis involves a multifaceted interplay of keratinocytes, blood vessels, immune system mediators and expressed genes.To determine whether genetic polymorphisms in the angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2) and caspase-5 (CASP5) genes are associated with an increased risk of developing psoriasis vulgaris (PV) in a Han population in ...
L. He, L. Dang, J. Zhou, J. Bai, Y.-Z. Li   +4 more
openaire   +2 more sources

Cyclic-stretch induces apoptosis in human periodontal ligament cells by activation of caspase-5

Archives of Oral Biology, 2017
As caspase-5 plays a role in apoptosis, the present study aimed to identify the expression and activation of caspase-5 in human periodontal ligament cells in response to cyclic stretch and the role of caspase-5 in stretch-induced apoptosis.Human PDL cells were exposed to 10% or 20% stretch strain for 6 or 24h, and the mRNA and protein expressions of ...
Zhao, Dan, Wu, Yaqin, Xu, Chun, Zhang, Fuqiang   +3 more
openaire   +4 more sources

BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability

International Journal of Colorectal Disease, 2004
Hereditary nonpolyposis colorectal cancer (HNPCC) and a subset of sporadic colorectal cancers are characterized by microsatellite instability (MSI) and inactivating frameshift mutations of target genes. Inactivation of BAX, caspase-5 ( cas-5), and other genes coding for pro-apoptotic proteins might contribute to tumor progression by enhancing escape ...
Joerg, Trojan, Angela, Brieger, Jochen, Raedle, Nicole, Weber, Susanne, Kriener, Bernd, Kronenberger, Wolfgang F, Caspary, Stefan, Zeuzem   +7 more
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The role of acid sphingomyelinase and caspase 5 in hypoxia-induced HuR cleavage and subsequent apoptosis in hepatocytes

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
A previous data showed that the hypoxia mimetic compound CoCl(2) induced cleavage of HuR and subsequent apoptosis in human oral cancer cells. We also previously demonstrated that exposure of NT-2 human neuronal precursor cells to hypoxia resulted in changes in sphingolipid levels and apoptosis. Since it is known that CoCl(2) induces cleavage of HuR, we
Qun, Zhu, Lianku, Lin, Qi, Cheng, Qing, Xu, Jingmei, Zhang, Stephen, Tomlinson, Junfei, Jin, Xiaoping, Chen, Songqing, He   +8 more
openaire   +2 more sources

Frameshift mutations in caspase-5 and other target genes in leukemia and lymphoma cell lines having microsatellite instability

Leukemia Research, 2003
Microsatellite instability (MSI) was examined in 49 lymphoid leukemia/lymphoma cell lines. Frameshift mutations within eight MSI target genes were analyzed in the 12 cell lines and nine childhood acute lymphoblastic leukemia (ALL) samples with MSI. Six cell lines (50%) showed mutations within the coding repeats of the BLM, caspase-5, TCF-4, and PTEN ...
Seisho, Takeuchi, Naoko, Takeuchi, Anthony C, Fermin, Hirokuni, Taguchi, H Phillip, Koeffler   +4 more
openaire   +2 more sources

Interaction between caspase‐3 and caspase‐5 in the stretch‐induced programmed cell death in the human periodontal ligament cells

Journal of Cellular Physiology, 2019
AbstractIn our previous studies, programmed cell death (PCD) was induced in human periodontal ligament (PDL) cells, through activation of caspase‐3 and upregulation of CASP5 gene (encoding caspase‐5 protein), in response to mechanical stretch loading. The aim of this study is to explore the relationship between the inflammatory caspase, caspase‐5, and ...
Yaqin Wu, Jiabao Zhuang, Dan Zhao, Chun Xu   +3 more
openaire   +4 more sources