Results 281 to 290 of about 11,510,202 (303)

Cyclic-stretch induces apoptosis in human periodontal ligament cells by activation of caspase-5

Archives of Oral Biology, 2017
As caspase-5 plays a role in apoptosis, the present study aimed to identify the expression and activation of caspase-5 in human periodontal ligament cells in response to cyclic stretch and the role of caspase-5 in stretch-induced apoptosis.Human PDL cells were exposed to 10% or 20% stretch strain for 6 or 24h, and the mRNA and protein expressions of ...
Yaqin Wu, Chun Xu, Fuqiang Zhang
exaly   +3 more sources

Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants

Biochemical and Biophysical Research Communications, 2006
Caspase-5 is a caspase-1-like protease with pro-apoptotic and pro-inflammatory activities. Here we have identified a novel exon at the 5'-end of the human caspase-5 gene. This novel exon was present in six alternatively spliced caspase-5 mRNA variants expressed in human peripheral blood mononuclear cells (PBMC) and encoded the previously unknown amino ...
Leopold, Eckhart, Christian, Kittel, Sonja, Gawlas, Florian, Gruber, Michael, Mildner, Bernd, Jilma, Erwin, Tschachler   +6 more
openaire   +2 more sources

The association between caspase-5 gene polymorphisms and rheumatoid arthritis in a Chinese population

Gene, 2018
Genetic factors are widely recognized to have a substantial effect on the susceptibility to rheumatoid arthritis (RA). We examined the contribution of caspase-5 (CASP5) gene polymorphisms to RA risk in a Chinese population. We conducted a case-control study involving 500 RA patients and 500 controls and performed co-expression analysis to identify ...
Huan, Rui, Ting, Yan, Zhiyong, Hu, Ruiping, Liu, Liqun, Wang   +4 more
exaly   +3 more sources

Frameshift mutations in caspase-5 and other target genes in leukemia and lymphoma cell lines having microsatellite instability

Leukemia Research, 2003
Microsatellite instability (MSI) was examined in 49 lymphoid leukemia/lymphoma cell lines. Frameshift mutations within eight MSI target genes were analyzed in the 12 cell lines and nine childhood acute lymphoblastic leukemia (ALL) samples with MSI. Six cell lines (50%) showed mutations within the coding repeats of the BLM, caspase-5, TCF-4, and PTEN ...
Seisho, Takeuchi, Naoko, Takeuchi, Anthony C, Fermin, Hirokuni, Taguchi, H Phillip, Koeffler   +4 more
openaire   +2 more sources

The role of acid sphingomyelinase and caspase 5 in hypoxia-induced HuR cleavage and subsequent apoptosis in hepatocytes

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
A previous data showed that the hypoxia mimetic compound CoCl(2) induced cleavage of HuR and subsequent apoptosis in human oral cancer cells. We also previously demonstrated that exposure of NT-2 human neuronal precursor cells to hypoxia resulted in changes in sphingolipid levels and apoptosis. Since it is known that CoCl(2) induces cleavage of HuR, we
Qun, Zhu, Lianku, Lin, Qi, Cheng, Qing, Xu, Jingmei, Zhang, Stephen, Tomlinson, Junfei, Jin, Xiaoping, Chen, Songqing, He   +8 more
openaire   +2 more sources

AB0112 Caspase-5 inhibitor suppresses pro-inflammatory gene expressions in fibroblast like synoviocytes from patients with rheumatoid arthritis

Annals of the Rheumatic Diseases, 2013
Background Caspases form an evolutionarily conserved family of cytosolic, aspartate-specific, cysteine proteases. Beyond its role in apoptosis, certain caspases (caspase-1, -4, -5, -11 and -12) exert non-apoptotic functions, including cytokine maturation during innate immunity, cell differentiation, proliferation, and NF-κB activation.
Y.-J. Kwon, T.-Y. Kim, S.-W. Lee, Y.-B. Park, S.-K. Lee, M.-C. Park   +5 more
openaire   +1 more source

Microsatellite mutations of transforming growth factor-β receptor type II and caspase-5 occur in human precursor T-cell lymphoblastic lymphomas/leukemias in vivo but are not associated with hMSH2 or hMLH1 promoter methylation

Leukemia Research, 2003
In solid cancers, defective DNA mismatch repair (MMR) is most commonly caused by hMSH2 or hMLH1 mutations, or epigenetic silencing of hMLH1 by promoter hypermethylation, and results in the acquisition of characteristic frameshift microsatellite mutations of mononucleotide repeats located within the coding regions of defined target genes.
Stuart A Scott
exaly   +3 more sources

TGF-βRIl, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder

Pathology, 2007
The aim of this study was to determine the potential synchronous contribution of alterations in TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 genes to the development and clinical outcome of bladder cancer, in relation to p53 mutations, microsatellite status and hMLH1/hMSH2 expression.Molecular biology techniques as well as immunohistochemistry ...
Angelica A, Saetta, Penelope, Korkolopoulou, Maria, Karlou, Georgia, Levidou, Athina, Goudopoulou, Irene, Thymara, Angeliki, Stamatelli, Michalis, Tzivras, Nikolaos V, Michalopoulos, Euphemia, Thomas-Tsagli, Efstratios, Patsouris   +10 more
openaire   +2 more sources

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death.

Journal of Molecular Biology, 2018
The Gasdermin (GSDM) family consists of Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME) and Pejvakin (PJVK). GSDMD is activated by inflammasome-associated inflammatory caspases. Cleavage of GSDMD by
Shouya Feng, D. Fox, Si Ming Man
semanticscholar   +1 more source

Indication of participation of caspase-2 and caspase-5 in mechanisms of human cervical malignancy.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2011
When apoptosis is disrupted, the transformed cells can survive, proliferate, and evolve into a malignancy. The strictly conserved caspase genes and the reliable experimental data clearly show that some caspases play a crucial role in apoptosis even if some of them have no apoptotic activity and others exhibit both apoptotic and nonapoptotic properties.
Evaggelos, Babas, Maria T, Ekonomopoulou, Irine, Karapidaki, Anestakis, Doxakis, George, Betsas, Zafiroula, Iakovidou-Kritsi   +5 more
openaire   +1 more source