Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María +3 more
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Frontiers in Microbiology, 2020 Background: Oral commensals contribute to microbe-host symbiosis in periodontal homeostasis, and Porphyromonas gingivalis (P. gingivalis) as the keystone pathogen critically accounts for the shift of symbiosis to dysbiosis and periodontal destruction ...
Pei-Hui Ding +11 more
doaj +1 more source
Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed +3 more
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Inflammasome priming in sterile inflammatory disease [PDF]
, 2017 The inflammasome is a cytoplasmic protein complex that processes interleukins (IL)-1β and IL-18, and drives a form of cell death known as pyroptosis. Oligomerization of this complex is actually the second step of activation, and a priming step must occur
Bryant, Clare E. +9 more
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The Relationship between the Bcl-2/Bax Proteins and the Mitochondria-Mediated Apoptosis Pathway in the Differentiation of Adipose-Derived Stromal Cells into Neurons. [PDF]
PLoS ONE, 2016 Our objective is to study the relationship between the regulatory proteins Bcl-2/Bax and mitochondria-mediated apoptosis during the differentiation of adipose-derived stromal cells (ADSCs) into neurons.
Quanquan Wang +9 more
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Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability. [PDF]
, 2016 Monocytes play a central role in regulating inflammation in response to infection or injury, and during auto-inflammatory diseases. Human blood contains classical, intermediate and non-classical monocyte subsets that each express characteristic patterns ...
A MacKenzie +53 more
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Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells [PDF]
, 2017 The human pathogen enteropathogenic Escherichia coli (EPEC), as well as the mouse pathogen Citrobacter rodentium, colonize the gut mucosa via attaching and effacing lesion formation and cause diarrheal diseases. EPEC and C.
Berger, C. N. +9 more
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Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential
Journal of Inflammation Research, 2022 Jingjing Liu,1– 3 Guoqing Fan,1– 3 Ningning Tao,4 Tieying Sun1,2 1Department of Respiratory Medicine and Critical Care, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing ...
Liu J, Fan G, Tao N, Sun T
doaj
Apoptotic and nonapoptotic function of caspase 7 in spermatogenesis
Asian Journal of Andrology, 2017 Recent studies have reported that caspase 7 has an apoptotic and nonapoptotic function. However, the relationship between caspase 7 and spermatogenesis remains unknown.
Bin Lei +7 more
doaj +1 more source
Effects of Mimosa pudica L. leaves extract on anxiety, depression and memory [PDF]
Avicenna Journal of Phytomedicine, 2016 Objective: The present study was carried out to investigate the neuropharmacological activities of ethyl acetate extract of Mimosa pudica (EAMP) leaves on anxiety, depression and memory in a mouse model.
Ganesh Patro +2 more
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