Results 71 to 80 of about 11,510,202 (303)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Caspase Gene Expression in Colon Cancer Cells Exposed to 5-Fluorouracil Treatment

Proceedings
Colorectal cancer is the third most common type of cancer and remains a significant global health challenge [...]
Jelena Pavić, Marko Živanović, Irena Tanasković, Katarina Virijević, Tamara Mladenović, Nenad Filipović   +5 more
doaj   +1 more source

Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway

Acta Pharmaceutica, 2020
Curcumin is a lipophilic anti-cancer compound extracted from turmeric. Our previous study demonstrated that the curcumin-loaded nanostructured lipid carrier (Cur-NLC) exhibits superior anti-cancer activity in inhibiting proliferation as well as inducing ...
Wang Fengling, Ye Xi, Zhai Dandan, Dai Wenting, Wu Yifan, Chen Jin, Chen Weidong   +6 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

The Relationship Between the Expression of Resistin and Apoptosis Factors in Placenta and the Pathogenesis of Gestational Diabetes Mellitus

Maternal-Fetal Medicine, 2020
. Objective:. To detect the expression of caspase-3, baculoviral inhibitor of apoptosis repeat containing 5 (BIRC-5), vascular endothelial growth factor (VEGF), hypoxia-inducible factor (HIF), and the concentration of resistin protein in placental of ...
Jun Yu, Xiao-Ling Su, Jing Jia, Yu Zeng, Jing-Yi Zhang, Shao-Shuai Wang, Ling Feng, Yang Pan, Dan-Dan Shi   +8 more
doaj   +1 more source

The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases

Cell Reports, 2023
Summary: Inflammasomes are multiprotein signaling complexes that activate the innate immune system. Canonical inflammasomes recruit and activate caspase-1, which then cleaves and activates IL-1β and IL-18, as well as gasdermin D (GSDMD) to induce ...
Patrick M. Exconde, Claudia Hernandez-Chavez, Christopher M. Bourne, Rachel M. Richards, Mark B. Bray, Jan L. Lopez, Tamanna Srivastava, Marisa S. Egan, Jenna Zhang, William Yoo, Sunny Shin, Bohdana M. Discher, Cornelius Y. Taabazuing   +12 more
doaj   +1 more source

Genomic and proteomic profiling of responses to toxic metals in human lung cells. [PDF]

, 2003
Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response ...
Andrew, Angeline S, Barchowsky, Aaron, Hamilton, Joshua W, Klei, Linda, O'Hara, Kimberley A, Soucy, Nicole V, Temple, Kaili A, Warren, Amy J   +7 more
core   +2 more sources

Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis. [PDF]

, 2015
Tuberculosis (TB) is considered a major worldwide health problem with 10 million new cases diagnosed each year. Our understanding of TB immunology has become greater and more refined since the identification of Mycobacterium tuberculosis (MTB) as an ...
A Aderem, A Azzurri, A Bafica, A Kumar, A Mantovani, AB Kamath, AC Ogus, AG Bean, Ali Akbar Velayati, B Abel, B Albiger, B Bottazzi, BB Mishra, BE Schneider, C Garlanda, C Garlanda, C Nathan, C Picard, CA Dinarello, CA Scanga, CC Khor, CH Ladel, CM Fremond, CM Fremond, D Biswas, D Castaño, D Kebir El, Davood Mansouri, DG Souza, DM Underhill, DR Andrade Jr, DR Velez, E Giacomini, E Kay, E Lorenz, E Meylan, E Mortaz, E Torrado, EA Kurt-Jones, EK Jo, Esmaeil Mortaz, F Breviario, F Martinon, G Courtois, G Fenhalls, GA Rook, GW Lee, GW Lee, GY Chen, H Hemmi, H Kumar, H Kumar, H Yamada, HM Lee, I Sugawara, Ian M. Adcock, IC Koo, J Branger, J Bustamante, J Chan, J Kleinnijenhuis, J Kleinnijenhuis, J Kluijver de, J Zuñiga, JC Mak, Jean-Laurent Casanova, JJ Yim, JL Casanova, JP Ting, JS Beckman, K Happel, K Takeda, KD Mayer-Barber, L Alexopoulou, L Gan, L Pompei, LA Pinxteren Van, LG Montgomery, M Gurumurthy, M Introna, M Songane, M Zhang, MB Drennan, MG Drage, MJ Ma, MJ Newport, MM Hossain, Mohammad Reza Masjedi, N Najmi, N Reiling, N Reiling, NC Arbour, NT Thuong, O Takeuchi, P Fietta, P Hartmann, P Selvaraj, P Ye, P Ye, Payam Tabarsi, Peter J. Barnes, R Bryk, R Crevel Van, R Döffinger, R Medzhitov, R Olesen, RC Langen, S Ahmad, S Akira, S Akira, S Akira, S Akira, S Cui, S Davila, S Mariathasan, S Nakae, S Shi, SA Khader, SA Khader, SF Azfar, SL Doyle, SR Krutzik, SS Master, T Kawai, T Kawai, T Kawai, T Ulrichs, TJ Kang, TK Means, TK Means, TM Wozniak, V Quesniaux, V Vouret-Craviari, Y Bulut, Y Liu, Y Xue, Y Zhang   +136 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A Caterpiller molekulák szerepe a szaruhártya természetes immunitásának kialakításában = The role of Caterpiller molecules in the innate immunity of the cornea [PDF]

, 2011
Munkánk során humán korneális epitélsejteken és keratinocitákon vizsgáltuk az intracelluláris mintázatfelismerő Nod-like receptor (NLR) család expresszióját és a fehérjék lehetséges szerepét.
Benkő, Szilvia
core