Results 151 to 160 of about 279,199 (293)

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source

Optogenetic induction of caspase-8 mediated apoptosis by employing Arabidopsis cryptochrome 2. [PDF]

Sci Rep, 2023
Mo W, Su S, Shang R, Yang L, Zhao X, Wu C, Yang Z, Zhang H, Wu L, Liu Y, He Y, Zhang R, Zuo Z.   +12 more
europepmc   +1 more source

Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8 [PDF]

, 2001
Frank Kischkel, David A. Lawrence, Antoine Tinel, Heidi Leblanc, Arvind K. Virmani, Peter Schow, Adi F. Gazdar, John Blenis, David Arnott, Avi Ashkenazi   +9 more
openalex   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer. [PDF]

Cancers (Basel), 2023
Contadini C, Ferri A, Cirotti C, Stupack D, Barilà D.   +4 more
europepmc   +1 more source

Caspase-9 Activation Results in Downstream Caspase-8 Activation and Bid Cleavage in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease [PDF]

, 2001
Veena Viswanath, Yongqin Wu, Rapee Boonplueang, Sylvia Chen, Fang Feng Stevenson, Ferda Yantiri, Lichuan Yang, M. Flint Beal, Julie K. Andersen   +8 more
openalex   +1 more source

Caspase-8 activation

Reactome - a curated knowledgebase of biological pathways, 2013
openaire   +1 more source

Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity

Advanced Science, EarlyView.
In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang, Jiahui Zou, Yaoming Jin, Chenjun Jiang, Shaoyu Tu, Tong Chen, Jinli Guo, Yanqing Cheng, Meilin Jin, Huanchun Chen, Hongbo Zhou   +10 more
wiley   +1 more source

RAD51 modulates in nasopharyngeal carcinoma cells by regulating Caspase-8-mediated pyroptosis. [PDF]

Discov Oncol
Xie F, Song J, Tian Y, Zhang X, Chen T, Xu M.   +5 more
europepmc   +1 more source

Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection [PDF]

, 2001
Penny Clarke, Suzanne M. Meintzer, Aaron C. Spalding, Gary L. Johnson, Kenneth L. Tyler   +4 more
openalex   +1 more source