Results 11 to 20 of about 279,199 (293)

Functions of caspase 8: The identified and the mysterious [PDF]

open access: yesSeminars in Immunology, 2014
Initially discovered as an initiator protease in apoptosis mediated by death receptors, caspase-8 is now known to have an apparently confounding opposing effect in securing cell survival. It is required to allow mouse embryo survival, and the survival of hematopoietic cells during their development and activation.
Salvesen, Guy S, Walsh, Craig M
openaire   +6 more sources

Role of caspase-8 in thymus function [PDF]

open access: yesCell Death & Differentiation, 2013
The thymus is the primary organ responsible for de novo generation of immunocompetent T cells that have a diverse repertoire of antigen recognition. During the developmental process, 98% of thymocytes die by apoptosis. Thus apoptosis is a dominant process in the thymus and occurs through either death by neglect or negative selection or through ...
POZZESI, NICOLA   +6 more
openaire   +3 more sources

Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling

open access: yesFrontiers in Pharmacology, 2022
Purpose: The incidence of uric acid (UA)-induced kidney injury is increasing owing to the high incidence of hyperuricemia in recent years. The flower of Abelmoschus manihot (Linneus) Medik is a traditional Chinese medicinal herb widely used in the ...
Zhihui Ding   +14 more
doaj   +1 more source

RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis.

open access: yesPLoS Pathogens, 2022
Invasion of the brain by herpes simplex virus 1 (HSV1) can lead to the development of herpes simplex encephalitis (HSE) that is often associated with significant morbidity and mortality regardless of therapeutic intervention.
Hongyan Guo   +3 more
doaj   +1 more source

Caspase‐8: regulating life and death [PDF]

open access: yesImmunological Reviews, 2017
SummaryRoles for cell death in development, homeostasis, and the control of infections and cancer have long been recognized. Although excessive cell damage results in passive necrosis, cells can be triggered to engage molecular programs that result in cell death.
Bart Tummers, Douglas R. Green
openaire   +3 more sources

Altered of apoptotic markers of both extrinsic and intrinsic pathways induced by hepatitis C virus infection in peripheral blood mononuclear cells

open access: yesVirology Journal, 2012
Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme   +11 more
doaj   +1 more source

Caspase-8 Potentiates Triglyceride (TG)-Induced Cell Death of THP-1 Macrophages via a Positive Feedback Loop

open access: yesKorean Journal of Clinical Laboratory Science, 2021
Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung   +3 more
doaj   +1 more source

Apoptotic Volume Decrease (AVD) Is Independent of Mitochondrial Dysfunction and Initiator Caspase Activation

open access: yesCells, 2012
Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata   +2 more
doaj   +1 more source

TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis

open access: yesCell Death Discovery, 2023
Sarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated with the development of sarcopenia that is characterized by reduction of muscle fiber size and number ...
Jingying Wu   +9 more
doaj   +1 more source

Caspase-8: Fly or Die [PDF]

open access: yesCancer Research, 2008
Abstract Recent studies have revealed that procaspase-8 has an important function in cell adhesion and motility. Src phosphorylation controls this function by preventing the conversion of procaspase-8, which is an adhesion/migration factor, to mature caspase-8, which is an apoptosis-inducing factor.
openaire   +3 more sources

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