Polypyrimidine Track-binding Protein Binding Downstream of Caspase-2 Alternative Exon 9 Represses Its Inclusion [PDF]
, 2001 Jocelyn Côté +2 more
openalex +1 more source
Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery
Advanced Healthcare Materials, EarlyView.Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang +6 more
wiley +1 more source
Caspases 3 and 9 Send a Pro-Apoptotic Signal from Synapse to Cell Body in Olfactory Receptor Neurons [PDF]
, 2001 Catherine M. Cowan +6 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao +20 more
wiley +1 more source
Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes. [PDF]
iScience, 2023 Yadav PS +3 more
europepmc +1 more source
Caspase-9 Activation Results in Downstream Caspase-8 Activation and Bid Cleavage in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease [PDF]
, 2001 Veena Viswanath +8 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah +9 more
wiley +1 more source
Oxidative stress and increased levels of apoptosis (Cytochrome C, Caspase 3 and 9) in patients with male-factor infertility. [PDF]
, 2001 X Wang +5 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.A simplified, co‐culture‐free protocol for kidney organoids that generate segmented nephrons, including collecting ducts, has been developed. Early low‐dose RA with FGF9 induces balanced anterior–posterior IM patterning and dual UE/MM lineage commitment. BMP7 enhances nephron progenitor maturation.
Jung Hwa Lim +13 more
wiley +1 more source
Inducible caspase 9-mediated suicide gene therapy using AAV6 vectors in a murine model of breast cancer. [PDF]
Mol Ther Methods Clin Dev, 2023 Pathak S +3 more
europepmc +1 more source