Results 121 to 130 of about 324,387 (342)

Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cells

Journal of Experimental & Clinical Cancer Research, 2018
Background Epstein-Barr virus (EBV) is widely found in nasopharyngeal carcinoma (NPC) tissue and associated with poor prognosis of patients. EBV nuclear antigen 1 (EBNA1) is expressed in all NPC tumors and plays multiple biological roles in both virus ...
Heng Zhou, Yu Liu, Chao Wang, Limei Liu, Huan Wang, Yaqian Zhang, Cong Long, Xiaoping Sun   +7 more
doaj   +1 more source

Photoluminescent And Self-Assembled Hyaluronic Acid-Zinc Oxide-Ginsenoside Rh2 Nanoparticles And Their Potential Caspase-9 Apoptotic Mechanism Towards Cancer Cell Lines [PDF]

, 2019
Background: Zinc oxide nanoparticles (ZnO NPs) are used in modern cancer therapy based on their specific target, efficacy, low toxicity and biocompatibility.
Castro-Aceituno, Veronica, Kim, Donghyuk, Kim, Sung, Kim, Yeon Ju, Lee, Seungah, Liu, Ying, Markus, Josua, Perumalsamy, Haribalan, Yang, Deok Chun   +8 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Apoptotic Effects of Triterpenoids Isolated from <i>Pleiocarpa Pycnantha</i> Leaves in Cancer Cells&nbsp;and Molecular Docking Study of the Interactions of Camptothecin and Ursolic Acid with Human Caspases 3 and 9

, 2022
Olubunmi Adenike Akinwunmi, Babatunde Joseph Oso, Nicole Remaliah Samantha Sibuyi, Ivan R. Green, Emmanuel I. Iwouha, Mervin Meyer, Ahmed Mohammed Hussein   +6 more
openalex   +1 more source

Bcl-2 protein family: Implications in vascular apoptosis and atherosclerosis [PDF]

, 2006
Apoptosis has been recognized as a central component in the pathogenesis of atherosclerosis, in addition to the other human pathologies such as cancer and diabetes.
A Ashkenazi, A Bakhshi, A Basu, A Gross, A Letai, A Mandic, A Nechushtan, A Nechushtan, A Ruiz-Vela, A Saxena, A Schinzel, A Strasser, AE Rusinol, AJ Bruce-Keller, AP Gilmore, AS Belzacq, AZ Badrichani, B Antonsson, B Fadeel, B Hufnagel, C Adrain, C Borner, C Napoli, C Scaffidi, C Soldani, D de Moissac, D Decaudin, D Heiser, DE Wood, DG Kirsch, DJ Veis, DM Finucane, DW Dickson, E Oda, EA Slee, EH Cheng, EJ Ackermann, FA Sinicrope, G Basanez, G Molostvov, G van Loo, G van Loo, GD Norata, GJ Griffiths, GV Putcha, H He, H Kataoka, H Li, HH Kim, HS Lee, Huveyda Basaga, I Marzo, I Marzo, J Chen, J Han, J Liu, J Masuda, J Yang, J Yu, J Yu, J Zha, JC Reed, JL Bodmer, K Nakano, K Ochs, K Sakurai, K Wang, K Yamamoto, KM Hajra, KM Murphy, L He, M Aritomi, M del Mar Martinez-Senac, M Narita, M Nguyen, M Sata, M Sata, M Sattler, MB Bogdanov, MC Wei, MJ Pollman, MM Kockx, MR Bennett, MR Morissette, MR Sprick, MY Donath, N Donovan, N Mirkovic, N Motoyama, O Kutuk, O Meilhac, OW Rokhlin, Ozgur Kutuk, P Pauletto, PM Yao, Q Huang, R Rashmi, R Ross, R Ross, RA Gottlieb, RJ Alvarez, RM Kluck, S Conus, S Desagher, S Dramsi, S Grethe, S Krajewski, S Nouraini, S Ottilie, S Shimizu, S Takarada, S Vicca, S Vicca, SA Keogh, SA Memon, SC Ruffolo, SJ Korsmeyer, SJ Korsmeyer, SJ Neame, SL Schendel, SN Willis, SR Datta, SR Datta, SW Muchmore, SY Hsu, T Ito, T Lee, T Shibue, TD Littlewood, TS Soderstrom, UK Messmer, V Mikhailov, V Mikhailov, V Petronilli, V Petronilli, W Zhang, X Cao, XM Sun, Y Deng, Y Gazitt, Y Konishi, Y Liang, Y Michowitz   +142 more
core   +1 more source

Incorporation of Selenium into Sol–Gel‐Derived Bioactive Glass: Influence on Glass Structure, Bioactivity, and its Selective Cytotoxicity

Advanced Engineering Materials, EarlyView.
Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni, Thalita Marcolan Valverde, Talita Martins, Guilherme Mattos Jardim Costa, Alfredo Miranda de Goes, Marcello Rosa Dumont, Eduardo Henrique Martins Nunes, Marivalda de Magalhães Pereira   +7 more
wiley   +1 more source

TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells

BMC Cancer, 2006
Background Activation of caspase-9 in response to treatment with cytotoxic drugs is inhibited in NSCLC cells, which may contribute to the clinical resistance to chemotherapy shown in this type of tumor. The aim of the present study was to investigate the
Ferreira Carlos G, Hoogeland Bas SJ, Giaccone Giuseppe, Checinska Agnieszka, Rodriguez Jose A, Kruyt Frank AE   +5 more
doaj   +1 more source

A Surface‐engineered Microfluidic Device for Antibody‐Mediated Negative Selection of High‐Quality Sperm for Assisted Reproduction

Advanced Functional Materials, EarlyView.
This study reports a microfluidic device with a functionalized surface utilizing a polyoxazoline coating and covalently immobilized gold nanoparticles and anti‐phosphatidylserine antibody. The device efficiently eliminates pre‐apoptotic and apoptotic spermatozoa and yields sperm with substantially improved quality and low DNA damage, offering a simple ...
Soraya Rasi Ghaemi, David J. Sharkey, Nicole O. McPherson, Markos Negash Alemie, Krasimir Vasilev, Sarah A. Robertson   +5 more
wiley   +1 more source

Impact of Teriparatide Acetate on Caspase-9 Gene Expression in Relation to Histological and Tunnel Assay of Apoptosis in Rat Kidneys and Livers [PDF]

Journal of Applied Veterinary Sciences
The study aimed to evaluate the effects of Teriparatide on liver and kidney tissues in rats and to examine the relationship between these effects and the gene expression of caspase-9 focusing on the mechanism of apoptosis. The experiment included 20 male
Saif Al-Jammas, Ghada Taqa, Ayad AL_Saraj   +2 more
doaj   +1 more source

Supplementary Figure and Table Legends from Alternative Splicing of Caspase 9 Is Modulated by the Phosphoinositide 3-Kinase/Akt Pathway via Phosphorylation of SRp30a

, 2023
Jacqueline C. Shultz, Rachel W. Goehe, Dayanjan S. Wijesinghe, Charuta Murudkar, Amy J. Hawkins, Jerry W. Shay, John D. Minna, Charles E. Chalfant   +7 more
openalex   +1 more source