Advanced Science, EarlyView.Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang +16 more
wiley +1 more source
Binding and Kinetic Analysis of Human Protein Phosphatase PP2A Interactions with Caspase 9 Protein and the Interfering Peptide C9h. [PDF]
Pharmaceutics, 2022 Dorgham K +5 more
europepmc +1 more source
Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo [PDF]
, 1998 Razqallah Hakem +15 more
openalex +1 more source
Growth-Suppressive and Apoptosis-Inducing Effects of Tetrandrine in SW872 Human Malignant Liposarcoma Cells via Activation of Caspase-9, Down-Regulation of XIAP and STAT-3, and ER Stress [PDF]
, 2022 Mohammed Samsuzzaman +1 more
openalex +1 more source
Advanced Science, EarlyView.Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu +13 more
wiley +1 more source
Targeted biallelic integration of an inducible Caspase 9 suicide gene in iPSCs for safer therapies. [PDF]
Mol Ther Methods Clin Dev, 2022 Wunderlich S +17 more
europepmc +1 more source
C5b-9 Terminal Complex Protects Oligodendrocytes from Apoptotic Cell Death by Inhibiting Caspase-8 Processing and Up-Regulating FLIP [PDF]
, 2006 Cornelia Cudrici +7 more
openalex +1 more source
Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells
Advanced Science, EarlyView.Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li +8 more
wiley +1 more source
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy. [PDF]
Acta Pharmacol Sin, 2023 Li L +9 more
europepmc +1 more source
Chemopreventive Effect of Curcumin on Oxidative Stress, Antioxidant Status, DNA Fragmentation and Caspase-9 Gene Expression in 1,2-dimethylhydrazine-induced Colon Cancer in Rats [PDF]
, 2013 Aziza Amin +2 more
openalex +1 more source