Results 281 to 290 of about 5,120,269 (330)

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

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Regulation of cell death protease caspase-9 by phosphorylation.

Science, 1998
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro–caspase-9 (pro-Casp9) in cells. Cytochrome c–induced proteolytic processing of pro-Casp9 was defective in cytosolic extracts from cells expressing either active Ras or Akt.
M. Cardone, N. Roy, H. Stennicke, G. Salvesen, T. Franke, E. Stanbridge, S. Frisch, John Calvin Reed   +7 more
semanticscholar   +3 more sources

Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9.

Journal of Ethnopharmacology, 2020
ETHNOPHARMACOLOGICAL RELEVANCE The mushroom Ganoderma lucidum (G. lucidum) is a traditional Chinese medicine reported to have a variety of pharmacological properties, including anti-cancer activity. G.
C. Jiao, Wang-Chi Chen, X. Tan, Huijia Liang, Jieyi Li, Hao Yun, Chunyan He, Jiaming Chen, Xiaowei Ma, Yizhen Xie, Burton B. Yang   +10 more
semanticscholar   +1 more source

Caspase-9 regulation: An update

Apoptosis, 2004
The complex sequence of events leading to apoptotic cell death is governed by an elaborate regulatory scheme involving the actions of both initiator and executioner proteases. Among the most intensively studied of the initiator caspases is caspase-9, an essential throughput element in the so-called intrinsic or mitochondrially gated pathway of ...
C R, Johnson, W D, Jarvis
openaire   +2 more sources

Akt Phosphorylation Site Found in Human Caspase-9 Is Absent in Mouse Caspase-9

Biochemical and Biophysical Research Communications, 1999
Caspase-9 is one caspase upstream of caspase-3 and its activation is stimulated by Apaf-1/cytochrome c and inhibited by Akt signals. BAD phosphorylation by Akt is an essential step for growth factor-mediated inhibition of caspase activation. Recently, it was shown that human caspase-9 is phosphorylated by Akt and that its protease activity is reduced ...
E, Fujita, A, Jinbo, H, Matuzaki, H, Konishi, U, Kikkawa, T, Momoi   +5 more
openaire   +2 more sources

Delineation of the caspase-9 signaling cascade

Apoptosis, 2007
In the intrinsic apoptosis pathway, mitochondrial disruption leads to the release of multiple apoptosis signaling molecules, triggering both caspase-dependent and -independent cell death. The release of cytochrome c induces the formation of the apoptosome, resulting in caspase-9 activation.
Alan D, Guerrero, Min, Chen, Jin, Wang
openaire   +2 more sources

Peptide-functionalized upconversion nanoparticles-based FRET sensing platform for Caspase-9 activity detection in vitro and in vivo.

Biosensors & bioelectronics, 2019
In the present work, peptide-functionalized upconversion@silica nanoparticle (termed as UCNP@SiO2@Cy5-pep)-based fluorescence resonance energy transfer (FRET) sensing platform has been fabricated for the detection of caspase-9 activity in vitro and in ...
Lin Liu, Hua Zhang, Zhenxin Wang, D. Song   +3 more
semanticscholar   +1 more source

Caspase-9

The International Journal of Biochemistry & Cell Biology, 2000
Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP.
openaire   +2 more sources

Caspase 9 is decreased in psoriatic epidermis

Acta Histochemica, 2006
Psoriasis is a proliferative and inflammatory disease of the skin. Caspase 9 is responsible for initiating the caspase activation cascade during apoptosis. Apoptosis is a physiological mechanism of homeostasis and development, and caspases are the executioners of apoptosis.
Oemeroglu, SUNA, Oeztas, MURAT ORHAN, Guerer, Mehmet Ali, Alli, Nuran, Oeztas, Pinar, Lortlar, Nese   +5 more
openaire   +3 more sources

Caspase-9 inhibition decreases expression of Mmp9 during chondrogenesis

Histochemistry and Cell Biology, 2022
Besides cell death, caspase-9 participates in non-apoptotic events, including cell differentiation. To evaluate a possible impact on the expression of chondrogenic/osteogenic factors, a caspase-9 inhibitor was tested in vitro. For this purpose, mouse forelimb-derived micromass cultures, the most common chondrogenic in vitro model, were used.
A. Ramesova, B. Vesela, E. Svandova, H. Lesot, E. Matalova   +4 more
openaire   +2 more sources