Results 291 to 300 of about 5,120,269 (330)

Caspase-9 as a therapeutic target for treating cancer

Expert Opinion on Therapeutic Targets, 2015
Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms. Its activation is believed to involve homo-dimerization of the monomeric zymogens. It binds to the apoptosome to retain substantial catalytic activity.
Bonglee Kim, S. Srivastava, Sung-Hoon Kim   +2 more
semanticscholar   +3 more sources

The role of caspase‐8, caspase‐9, and apoptosis inducing factor in periodontal disease

The Journal of Periodontology, 2018
BACKGROUND Caspases are key mediators of apoptosis. Caspase-8 mediates extrinsic, and caspase-9 initiates the intrinsic pathway of apoptosis. Apoptosis Inducing Factor (AIF), a mitochondrial proapoptotic protein, mediates cell death by a caspase ...
K. Aral, C. A. Aral, Y. Kapila
semanticscholar   +1 more source

Expression of phosphorylated caspase‐9 in gastric carcinomas

APMIS, 2007
Alterations of caspases, the main executioners of apoptosis, have been described in human cancers. Caspase‐9 plays a crucial role in the initiation phase of the intrinsic apoptosis pathway. Caspase‐9 is phosphorylated at Thr125 through the mitogen‐activated protein kinase (MAPK) pathway, and this phosphorylation is associated with inhibition of caspase‐
Nam Jin, Yoo, Sung Hak, Lee, Eun Goo, Jeong, Sug Hyung, Lee   +3 more
openaire   +2 more sources

Caspase 9: context-dependent killer

Trends in Cell Biology, 1998
Abstract KUIDA, K. et al . (1998) Reduced apoptosis and cytochrome c -mediated caspase activation in mice lacking caspase 9 Cell 94, 325–337 Hakem, R. et al .
openaire   +1 more source

cDNA cloning and promoter analysis of rat caspase-9

Biochemical Journal, 2001
Caspase-9 is the apex caspase of the mitochondrial pathway of apoptosis, which plays a critical role in apoptotic initiation and progression. However, gene regulation of caspase-9 is largely unknown. This is in part due to the lack of information on the gene promoter.
J, Nishiyama, X, Yi, M A, Venkatachalam, Z, Dong   +3 more
openaire   +2 more sources

Caspase-9 activation in hypoxic human corneal epithelial cells

Apoptosis, 2003
The purpose of this study was to determine the effect of hypoxia on caspase-8 and -9 gene and protein expression and activity in corneal epithelium. Non-transformed human corneal epithelial cells (HCEC) were cultured in 2% oxygen. A cDNA expression array coupled with densitometric analysis was used to compare relative mRNA expression levels of 96 ...
M, Kurpakus-Wheater, R, Sexton, M L, McDermott, L K, Mrock, G, Sosne   +4 more
openaire   +2 more sources

Cytochrome C and Caspase-9 Expression in Huntington 's Disease

NeuroMolecular Medicine, 2002
There is increasing evidence implicating apoptosis-mediated cell death in the pathogenesis of neurodegenerative diseases. One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm, activating caspase-9, leading to the subsequent activation of downstream executioner caspases.
Tamara, Kiechle, Alpaslan, Dedeoglu, James, Kubilus, Neil W, Kowall, M Flint, Beal, Robert M, Friedlander, Steven M, Hersch, Robert J, Ferrante   +7 more
openaire   +2 more sources

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

Nature Immunology, 2020
Chuanhui Han, Zhida Liu, Yunjia Zhang, Aijun Shen, Chunbo Dong, A. Zhang, Casey Moore, Zhenhua Ren, Changzheng Lu, Xuezhi Cao, Chun-Li Zhang, J. Qiao, yang-xin fu   +12 more
semanticscholar   +1 more source

Caspase-9

2013
Bram J. van Raam, Guy S. Salvesen
openaire   +1 more source

Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017
Yuwan Zhao, Zuolei Jing, Jian Lv, Zhiwei Zhang, Jintao Lin, Xuejiao Cao, Zinan Zhao, Pixu Liu, Weifeng Mao   +8 more
semanticscholar   +1 more source