Results 51 to 60 of about 5,120,269 (330)
Caspase 9 Promoter Polymorphisms (-1263G>A, -905T>G, -712C>T) in Coronary Artery Disease [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: Apoptosis has been involved in a number of pathological conditions including Coronary Artery Disease (CAD). Caspases are important regulators and executioners in both extrinsic and intrinsic apoptotic pathways.
KISHORE KUMAR GUNDAPANENI +6 more
doaj +1 more source
Structure and Activation Mechanism of the Drosophila Initiator Caspase Dronc [PDF]
, 2006 Activation of an initiator caspase is essential to the execution of apoptosis. The molecular mechanisms by which initiator caspases are activated remain poorly understood.
Demeler, Borries +5 more
core +1 more source
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019 BACKGROUND Human multiple myeloma (MM) is a malignant and incurable B cell tumor. Zinc oxide nanoparticles (ZnO NPs) have been widely used in biomedical fields including anti-bacterial and anti-tumor.
Zonghong Li +7 more
semanticscholar +1 more source
Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome
Nature Catalysis, 2019 Living cells regulate key cellular processes by spatial organization of catalytically active proteins in higher-order signalling complexes. These act as organizing centres to facilitate proximity-induced activation and inhibition of multiple ...
B. Rosier +6 more
semanticscholar +1 more source
The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC [PDF]
, 2002 Although loss of the inhibitor of apoptosis (LAP) protein DIAP1 has been shown to result in caspase activation and spontaneous cell death in Drosophila cells and embryos, the point at which DIAP1 normally functions to inhibit caspase activation is ...
Clem, Rollie J. +2 more
core +1 more source
Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells [PDF]
, 2010 Inhibition or downregulation of Bcl-2 represents a new therapeutic approach to by-pass chemoresistance in cancer cells. Therefore, we explored the potential of this approach in breast cancer cells.
A Letai +34 more
core +1 more source
Molecular Therapy, 2017 Immunotherapy with T cells expressing the chimeric antigen receptor (CAR) specific for the CD19 antigen (CD19.CAR-Ts) is a very effective treatment in B cell lymphoid malignancies.
I. Diaconu +6 more
semanticscholar +1 more source
ROS‐dependent caspase‐9 activation in hypoxic cell death [PDF]
FEBS Letters, 2003 Mitochondria are known to play a fundamental role in apoptosis by releasing apoptogenic molecules such as cytochrome c into the cytoplasm, thereby sequentially activating initiator caspase‐9. However, the mechanisms of cytochrome c release or caspase‐9 activation in response to hypoxia are unclear. In this report, we show that caspase‐9 is activated by
Kim, Jee-Youn, Park, Jae-Hoon
openaire +2 more sources
Vitamin C inhibits endothelial cell apoptosis in congestive heart failure [PDF]
, 2007 Background - Proinflammatory cytokines like tumor necrosis factor- and oxidative stress induce apoptotic cell death in endothelial cells (ECs). Systemic inflammation and increased oxidative stress in congestive heart failure (CHF) coincide with enhanced ...
Aicher, A +9 more
core +1 more source
Caspase-9 cleavage, do you need it? [PDF]
Biochemical Journal, 2007 Caspase-9, which is activated by association with the Apaf-1 (apoptotic protease-activating factor-1) apoptosome complex, cleaves and activates the downstream effector caspases-3 and -7, thereby executing the caspase-cascade and cell-death programme. Although caspase-9 does not need to be cleaved to be active, apoptotic cell death is always accompanied
Twiddy, Davina, Cain, Kelvin
openaire +2 more sources