Results 51 to 60 of about 301,365 (321)
The Effect of Hepcidin on Cardiac Ischemia-Reperfusion Injury
Journal of Investigative Surgery, 2020 Background/aim: Hepcidin is the main hormone in the regulation of iron metabolism which is also released from the heart. The aim of our study was to investigate the effects of hepcidin on the cardiac ischemia-reperfusion injury. Materials and methods: In
Atilla Bayraktar +5 more
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Expression of caspase 9 and p53 in uterine leiomyosarcomas
Polish Gynaecology, 2014 Uterine sarcomas are heterogeneous malignancies, both clinically and histologically. The process of oncogenesis depends on gene mutations and uncontrolled mitotic cell division that is promoted by blocking pathways of apoptosis. Caspase 9 and p53 protein play an important role in the process of cell apoptosis.The aim of the study was to assess the ...
Wiesława Bednarek +5 more
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Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo [PDF]
Cell, 1998 Mutation of Caspase 9 (Casp9) results in embryonic lethality and defective brain development associated with decreased apoptosis. Casp9-/- embryonic stem cells and embryonic fibroblasts are resistant to several apoptotic stimuli, including UV and gamma irradiation.
Minna Woo +27 more
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Pramanicin induces apoptosis in Jurkat leukemia cells; a role for JNK, p38 and caspase activation [PDF]
, 2005 Pramanicin is a novel anti-fungal drug with a wide range of potential application against human diseases. It has been previously shown that pramanicin induces cell death and increases calcium levels in vascular endothelial cells. In the present study, we
Başağa, Hüveyda +3 more
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A Rapamycin-Activated Caspase 9-Based Suicide Gene [PDF]
Molecular Therapy, 2018 Engineered T cell therapies show considerable promise in the treatment of refractory malignancies. Given the ability of engineered T cells to engraft and persist for prolonged periods along with unpredicted toxicities, incorporation of a suicide gene to allow selective depletion after administration is desirable.
Stavrou, M +7 more
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Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]
, 2015 Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju +11 more
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Aquaculture and Fisheries, 2021 During low tide intertidal organisms face severe temperature fluctuations. This situation may be more pronounced in the context of climate change.
Fengshen Zhao, Heding Shen
doaj
Molecules, 2016 Pien Tze Huang (PZH) is a well-known traditional Chinese formulation and has long been used as an alternative remedy for cancers in China and Southeast Asia.
Yong Fu +7 more
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Prediction of the tertiary structure of a caspase‐9/inhibitor complex [PDF]
FEBS Letters, 2000 Apoptosis, or programmed cell death, plays a central role in the development and homeostasis of an organism. The breakdown of cellular proteins in apoptosis is mediated by caspases, which comprise a highly conserved family of cysteine proteases with specificity for aspartic acid residues at the P1 positions of their substrates.
Alfredo G. Tomasselli +2 more
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Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells [PDF]
, 2017 Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells in the bone marrow (BM). Recently, several studies have highlighted the role of pathogens in either promoting or dampening malignancies of unrelated origin.
Bertrand, Mathieu +11 more
core +3 more sources