Results 61 to 70 of about 5,120,269 (330)

Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors [PDF]

, 2015
Dysregulation of the cell cycle and cyclin-dependent kinases (cdks) is a hallmark of cancer cells. Intervention with cdk function is currently evaluated as a therapeutic option in many cancer types including neuroblastoma (NB), a common solid tumor of ...
Eggert, Angelika, Koester, Johannes, Lee, Sangkyun, Morik, Katharina, Schramm, Alexander, Schulte, Johannes H, Schwermer, Melanie, Stephan, Harald, Van Maerken, Tom   +8 more
core   +5 more sources

Effect of chlorpyrifos on the level of hippocampal caspase 9 in male rats: Short Commuincation

مجله دانشگاه علوم پزشکی بیرجند, 2023
Chlorpyrifos (CPF) is an organophosphate pesticide that can damage the nervous system of insects by causing neurotoxicity. Although the molecular mechanisms related to it are not fully understood, some studies have suggested that apoptotic processes are ...
Sina Nikbin, Armin Derakhshideh, Mohammad Ali Azarbayjani, Nasrin Hosseini   +3 more
doaj  

Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress–Induced Apoptosis in SH-SY5Y Cells

Journal of Pharmacological Sciences, 2011
The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress–induced apoptosis in human neuronal cell line SH-SY5Y.
Akiko Yamamuro, Takashi Kishino, Yu Ohshima, Yasuhiro Yoshioka, Tomoki Kimura, Atsushi Kasai, Sadaaki Maeda   +6 more
doaj   +1 more source

Suppression of the intrinsic apoptosis pathway by sinaptic activity [PDF]

, 2014
Synaptic activity promotes resistance to diverse apoptotic insults, the mechanism behind which is incompletely understood. We show here that a coordinated downregulation of core components of the intrinsic apoptosis pathway by neuronal activity forms a ...
Bell, Karen F. S., Fricker, Michael, Habel, Marlen, Hardingham, Giles E., Ikonomidou, Chrysanthy, Léveillé, Frédéric, Martel, Marc-André, Papadia, Sofia, Puddifoot, Clare, Soriano Zaragoza, Francesc X. (Francesc Xavier), Tolkovsky, Aviva M., Wyllie, David J. A.   +11 more
core   +2 more sources

The expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE1/AE3 in goats with enzootic nasal adenocarcinoma: an immunohistochemical study

Veterinární Medicína, 2013
The aim of this study was to examine the expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE-1/AE-3 using the avidin-biotin complex (ABC) immunoperoxidase technique in 20 goats with enzootic nasal adenocarcinoma (ENA).
A. Aydogan, M. Haligur, O. Ozmen
doaj   +1 more source

Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction. [PDF]

, 2016
Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis.
Jiao, Kun, Lau, Wayne Bond, Liu, Huirong, Liu, Xin, Ma, Lu, Ma, Xinliang, Shang, Jianyu, Wang, Ke, Wang, Wen, Wang, Xiaoliang, Yuan, Yuexing, Zuo, Lin   +11 more
core   +2 more sources

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

Journal of Cell Biology, 1999
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol, cytochrome c binds to the CED-4 homologue, Apaf-1, thereby triggering Apaf-1–mediated activation of caspase-9.
E. Slee, M. Harte, R. Kluck, B. Wolf, C. Casiano, D. Newmeyer, Hong-Gang Wang, John Calvin Reed, D. Nicholson, E. Alnemri, D. Green, Seamus J. Martin   +11 more
semanticscholar   +1 more source

Targeting colorectal cancer stem cells with inducible caspase-9 [PDF]

Apoptosis, 2012
Colorectal cancer stem cells (CSCs) drive tumor growth and are suggested to initiate distant metastases. Moreover, colon CSCs are reportedly more resistant to conventional chemotherapy, which is in part due to upregulation of anti-apoptotic Bcl-2 family members.
Kemper, Kristel, Rodermond, Hans, Colak, Selçuk, Grandela, Catarina, Medema, Jan Paul   +4 more
openaire   +3 more sources

Anti-Survival and Pro-Apoptotic Effects of 6-Shogaol on SW872 Human Liposarcoma Cells via Control of the Intrinsic Caspase Pathway, STAT-3, AMPK, and ER Stress

Biomolecules, 2020
Notably, 6-Shogaol, a bioactive natural substance, has anticancer effects on many types of tumors. Up to date, the anticancer effect and mode of action of 6-Shogaol on liposarcoma are not known.
Anil Kumar Yadav, Byeong-Churl Jang
doaj   +1 more source

Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines [PDF]

, 2017
Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia.
Cabrera, Maia Diana Eliana, Cardama, Georgina Alexandra, Davio, Carlos Alberto, Echeverría, Emiliana Beatriz, Fernandez, Natalia Cristina, González, Nazareno, Lorenzano Menna, Pablo, Remes Lenicov, Federico   +7 more
core   +2 more sources