Results 41 to 50 of about 333,383 (311)
Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
Frontiers in Cardiovascular Medicine, 2021 The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet ...
Jiayu Wu +3 more
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Cell Death & Differentiation, 1999 Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
P G, Ekert, J, Silke, D L, Vaux
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Frontiers in Pharmacology, 2020 There is an urgent unmet need to develop new therapeutics for lung squamous cell carcinoma (LSCC) as the current gold standard treatment regimens are dominated by chemotherapy.
Wuming Wang, Yuzhen Liu, Long Zhao
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Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
The Journal of Experimental Medicine, 1999 Uncontrolled lymphoproliferation is a characteristic feature of lymphomas and leukemias. Nonmalignant lymphoproliferative diseases are also observed in humans as well as in lpr (lymphoproliferation) and gld (generalized lymphadenopathy) mice. The discoveries that spontaneous mutations of Fas (APO-1/CD95) or its ligand (FasL) were associated with the ...
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Caspases as therapeutic targets [PDF]
Journal of Cellular and Molecular Medicine, 2008 Introduction Activation of caspases Small molecule inhibitors of caspase activity and activation Role of caspases in disease Challenges facing the development of caspase therapeutics Role of caspases in other aspects of cell death Role of caspases in non‐apoptotic and non‐inflammatory processes The future of caspase therapeutics AbstractThe ...
Howley, B., Fearnhead, H.O.
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The effect of oxidative stress on phagocytosis and apoptosis in the earthworm Eisenia hortensis [PDF]
Invertebrate Survival Journal, 2010 The effect of exogenous hydrogen peroxide (H202) on phagocytic function and apoptosis in coelomocytes from Eisenia hortensis was investigated. Treating coelomocytes with H202 (0.26 to 8.4 mM) evoked a significant increase in phagocytosis for one or more ...
SL Fuller-Espie +3 more
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Effective description of bistability and irreversibility in apoptosis [PDF]
arXiv, 2021 Apoptosis is a mechanism of programmed cell death in which cells engage in a controlled demolition and prepare to be digested without damaging their environment. In normal conditions apoptosis is repressed, until it is irreversibly induced by an appropriate signal.
arxiv
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
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Journal of Taibah University for Science, 2023 Breast cancer has been recorded as a frequent malignant cancer. The side effects of current chemotherapy drugs are still a severe problem. Hence, naturally occurring phytochemicals can be a possible solution to overcome this issue.
Muttiah Barathan +7 more
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