Results 41 to 50 of about 514,126 (359)

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8 [PDF]

Journal of Molecular Biology, 2018
Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
Sagulenko, Vitaliya, Vitak, Nazarii, Vajjhala, Parimala, Vince, James E, Stacey, Katryn J   +4 more
openaire   +4 more sources

Caspase-1 initiates apoptosis in the absence of gasdermin D

Nature Communications, 2019
Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis, which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still susceptible to caspase-1-mediated cell death.
K. Tsuchiya, S. Nakajima, S. Hosojima, Dinh Thi Nguyen, T. Hattori, Thuong Manh Le, O. Hori, M. Mahib, Y. Yamaguchi, M. Miura, T. Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, T. Shiroishi, T. Suda   +14 more
semanticscholar   +1 more source

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Here we demonstrate that Yersinia YopJ-induced murine macrophage death involves caspase-8–induced cleavage of both gasdermin D (GSDMD) and gasdermin E (GSDME).
Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Peng Li, R. Nilson, Amy Y. Tang, A. Rongvaux, S. Bunnell, F. Shao, D. Green, A. Poltorak   +10 more
semanticscholar   +1 more source

Evaluation of Cytotoxic and Apoptotic Effects of Simvastatin in Bone Cancer Cell line(MG-63)

Armaghane Danesh Bimonthly Journal, 2020
Background & aim: Cancer is a mismatch between cell growth and death that results in excessive accumulation of cells. Bone cancer is a very serious type of cancer and occurs when osteoporotic cells have problems. The aim of this study was to evaluate the
MA Soltani, T Naji, R Ahmadi
doaj  

Alpinia galanga induces caspase-dependent apoptotic cell death in human lung and cervical cancer cells [PDF]

Journal of HerbMed Pharmacology
Introduction: Alpinia galanga (L.) Willd is a rhizomatous, recurrent herb used to treat numerous diseases, including cancer. This study examines the efficiency of the different parts of A.
Alex Zohmachhuana, Nachimuthu Senthil Kumar, Malsawmdawngliana Malsawmdawngliana, Vabeiryureilai Mathipi, Lalrinzuali Lalrinzuali, Thangaraj Parimelazhagan, F. Lalnunmawia   +6 more
doaj   +1 more source

Delving into the Causes and Effects of Entomopathogenic Endophytic Metarhizium brunneum Foliar Application-Related Mortality in Spodoptera littoralis Larvae

Insects, 2020
The aim of the current study was to delve into the causes of mortality of Spodoptera littoralis larvae feeding on Metarhizium-colonized plants in the absence of fungal outgrowth on the cadavers as previous studies reported and to elucidate the possible ...
Inmaculada Garrido-Jurado, David Montes-Moreno, Pilar Sanz-Barrionuevo, Enrique Quesada-Moraga   +3 more
doaj   +1 more source

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

Journal of Experimental Medicine, 2018
Host-protective caspase-1 activity must be tightly regulated to prevent pathology, but mechanisms controlling the duration of cellular caspase-1 activity are unknown.
D. Boucher, Mercedes Monteleone, Rebecca C. Coll, Kaiwen W. Chen, Connie M. Ross, Jessica L. Teo, Guillermo A. Gomez, Caroline L. Holley, Damien Bierschenk, K. Stacey, A. Yap, Jelena S. Bezbradica, K. Schroder   +12 more
semanticscholar   +1 more source

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Science Advances, 2020
Caspase-8–dependent GSDMD activation promotes antibacterial defense; however, this pathway can also mediate TNF shock in vivo. Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of proinflammatory cytokines. Recent studies
B. Demarco, James P. Grayczyk, E. Bjanes, D. Le Roy, W. Tonnus, C. Assenmacher, E. Radaelli, Timothée Fettrelet, Vanessa Mack, A. Linkermann, T. Roger, I. Brodsky, Kaiwen W. Chen, P. Brož   +13 more
semanticscholar   +1 more source

DECAY, a novel Drosophilacaspase related to mammalian caspase-3 and caspase-7. [PDF]

Journal of Biological Chemistry, 1999
Caspases are key effectors of programmed cell death in metazoans. In Drosophila, four caspases have been described so far. Here we describe the identification and characterization of the fifth Drosophila caspase, DECAY. DECAY shares a high degree of homology with the members of the mammalian caspase-3 subfamily, particularly caspase-3 and caspase-7 ...
Dorstyn, L., Read, S., Quinn, L., Richardson, H., Kumar, S.   +4 more
openaire   +4 more sources

Caspases [PDF]

The Journal of Experimental Medicine, 1999
Uncontrolled lymphoproliferation is a characteristic feature of lymphomas and leukemias. Nonmalignant lymphoproliferative diseases are also observed in humans as well as in lpr (lymphoproliferation) and gld (generalized lymphadenopathy) mice. The discoveries that spontaneous mutations of Fas (APO-1/CD95) or its ligand (FasL) were associated with the ...
openaire   +2 more sources