Results 51 to 60 of about 580,743 (343)

Platelet Membrane Receptor Proteolysis: Implications for Platelet Function

Frontiers in Cardiovascular Medicine, 2021
The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet ...
Jiayu Wu, Johan W. M. Heemskerk, Constance C. F. M. J. Baaten, Constance C. F. M. J. Baaten   +3 more
doaj   +1 more source

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency [PDF]

, 2017
Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity.
Albert, Matthew L., Blyth, Karen, Bock, Florian, Cao, Kai, Cloix, Catherine, Dhayade, Sandeep, Fort, Loic, Giampazolias, Evangelos, Ichim, Gabriel, Lecis, Daniele, Lopez, Jonathan, Machesky, Laura, Milling, Simon, Oberst, Andrew, Orozco, Susana, Peltzer, Nieves, Proïcs, Emma, Ricci, Jean-Ehrland, Roca, Alba, Rubio-Patiño, Camila, Ryan, Kevin M., Tait, Stephen W.G., Taraborrelli, Lucia, Walczak, Henning, Woodham, Emma, Yatim, Nader, Zunino, Barbara   +26 more
core   +2 more sources

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release [PDF]

, 2017
Aims: Calcium phosphate (CaP) particle deposits are found in several inflammatory diseases including atherosclerosis and osteoarthritis. CaP, and other forms of crystals and particles, can promote inflammasome formation in macrophages leading to caspase ...
Afonina, Alexander N. Kapustin, Alfaidi, Bailet, Baroja-Mazo, Bautista Nino, Bennett, Burton, Catherine M. Shanahan, Chen, Cilla, Coopman, Cossetti, Cullen, Cunningham, Dautova, Diane Proudfoot, Duewell, Ehara, Erlinge, Ewence, Feil, Fuerst, Furman, Gross, Hanneke Okkenhaug, Hendriks, Hilgendorf, Hutcheson, Irkle, Iyemere, Jin, Kalra, Kapustin, Kevin Pappert, Kistowska, Krisenko, Laliberte, LaRocca, Lau, Li, Liu, Liu, Luga, Maldonado, Martin, Martin D. Bootman, Matthias Epple, Mfunyi, Migita, Mocsai, Molloy, Morgan, Nadra, Nakahara, Narayan, Ng, Pazar, Piccioli, Pugliese, Qu, Ragnauth, Ridker, Ruiz, Scimeca, Shamaa, Simon J. Cook, Smith, Song, Swaan, Vengrenyuk, Vigano, Virmani, Wang, Webber, Yana Dautova, Young   +76 more
core   +2 more sources

DECAY, a novel Drosophilacaspase related to mammalian caspase-3 and caspase-7. [PDF]

Journal of Biological Chemistry, 1999
Caspases are key effectors of programmed cell death in metazoans. In Drosophila, four caspases have been described so far. Here we describe the identification and characterization of the fifth Drosophila caspase, DECAY. DECAY shares a high degree of homology with the members of the mammalian caspase-3 subfamily, particularly caspase-3 and caspase-7 ...
Dorstyn, L., Read, S., Quinn, L., Richardson, H., Kumar, S.   +4 more
openaire   +4 more sources

Tambulin Targets Histone Deacetylase 1 Inhibiting Cell Growth and Inducing Apoptosis in Human Lung Squamous Cell Carcinoma

Frontiers in Pharmacology, 2020
There is an urgent unmet need to develop new therapeutics for lung squamous cell carcinoma (LSCC) as the current gold standard treatment regimens are dominated by chemotherapy.
Wuming Wang, Yuzhen Liu, Long Zhao
doaj   +1 more source

Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G [PDF]

, 2005
BACKGROUND: In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce apoptosis
Mishra, Rangnath, Simonson, Michael S
core   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Caspases [PDF]

The Journal of Experimental Medicine, 1999
Uncontrolled lymphoproliferation is a characteristic feature of lymphomas and leukemias. Nonmalignant lymphoproliferative diseases are also observed in humans as well as in lpr (lymphoproliferation) and gld (generalized lymphadenopathy) mice. The discoveries that spontaneous mutations of Fas (APO-1/CD95) or its ligand (FasL) were associated with the ...
openaire   +2 more sources

The effect of oxidative stress on phagocytosis and apoptosis in the earthworm Eisenia hortensis [PDF]

Invertebrate Survival Journal, 2010
The effect of exogenous hydrogen peroxide (H202) on phagocytic function and apoptosis in coelomocytes from Eisenia hortensis was investigated. Treating coelomocytes with H202 (0.26 to 8.4 mM) evoked a significant increase in phagocytosis for one or more ...
SL Fuller-Espie, T Nacarelli, EL Blake, FM Bearoff   +3 more
doaj  

Clinical translation of [18F]ICMT-11 for measuring chemotherapy-induced caspase 3/7 activation in breast and lung cancer [PDF]

, 2018
Background: Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [18F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have ...
Aboagye, Eric O., Cleator, S., Coombes, R. C., Dubash, S. R., Heinzmann, K., Inglese, M., Kenny, Laura, Kozlowski, K., Lavdas, I., Lewanski, C., Lim, A. K., Masrour, N., Mauri, F., Merchant, S., Rama, N., Steel, J. F., Thornton, A.   +16 more
core   +1 more source