Results 81 to 90 of about 514,126 (359)

Anti-inflammatory and antioxidant properties of oleuropein in human keratinocytes characterized by bottom-up proteomics

Frontiers in Pharmacology
Oleuropein is a phenolic compound commonly found in cosmetic ingredients including olive leaves and jasmine flowers with various skin-beneficial effects. Here, we evaluated oleuropein’s anti-inflammatory and antioxidant activities in human skin cells. In
Huifang Li, Ni Deng, Jiayi Yang, Yang Zhao, Xiaoxuan Jin, Ang Cai, Navindra P. Seeram, Hang Ma, Dongli Li, Huilan Yang, Chang Liu, Chang Liu   +11 more
doaj   +1 more source

CAPE Analogs Induce Growth Arrest and Apoptosis in Breast Cancer Cells

Molecules, 2015
Breast cancer is the second leading cause of death amongst women worldwide. As a result, many have turned their attention to new alternative approaches to treat this disease.
Annie-Pier Beauregard, Jason Harquail, Grégoire Lassalle-Claux, Mehdi Belbraouet, Jacques Jean-Francois, Mohamed Touaibia, Gilles A. Robichaud   +6 more
doaj   +1 more source

Senescence and Apoptosis During in vitro Embryo Development in a Bovine Model

Frontiers in Cell and Developmental Biology, 2020
According to the World Health Organization, infertility affects up to 14% of couples under reproductive age, leading to an exponential rise in the use of assisted reproduction as a route for conceiving a baby.
Priscila Ramos-Ibeas, Isabel Gimeno, Karina Cañón-Beltrán, Alfonso Gutiérrez-Adán, Dimitrios Rizos, Enrique Gómez   +5 more
doaj   +1 more source

Inhibition of distant caspase homologues by natural caspase inhibitors [PDF]

Biochemical Journal, 2001
Caspases play an important role in the ability of animal cells to kill themselves by apoptosis. Caspase activity is regulated in vivo by members of three distinct protease inhibitor families, two of which, baculovirus p35 and members of the inhibitor of apoptosis (IAP) family, are thought to be caspase specific.
Guy S. Salvesen, Alan J. Barrett, Stefan J. Riedl, James Travis, Scott J. Snipas, Jan Potempa, Jan Potempa, Henning R. Stennicke   +7 more
openaire   +4 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

Journal of Biological Chemistry, 1997
There is compelling evidence that members of the caspase (interleukin-1β converting enzyme/CED-3) family of cysteine proteases and the cytotoxic lymphocyte-derived serine protease granzyme B play essential roles in mammalian apoptosis.
N. Thornberry, T. Rano, E. Peterson, D. Rasper, Tracy Timkey, M. Garcia-Calvo, V. Houtzager, P. Nordstrom, Sophie Roy, J. Vaillancourt, K. Chapman, D. Nicholson   +11 more
semanticscholar   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Caspase mediated cytotoxicity of a yellow pigment produced by Exiguobacterium alkaliphilum on human cancer cell lines [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2020
Context: Investigation of microbial diversity for the identification of novel bioactive compounds or therapeutics is a more potential and incessant ongoing process for drug development research.
Bharath Gajaraj, Varalakshmi Nadumane
doaj  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source